Lack of association between serotonin transporter gene polymorphism 5-HTTLPR and smoking among Polish population: a case-control study

Siemińska, Alicja; Buczkowski, Krzysztof; Jassem, Ewa; Tkacz, Ewa

doi:10.1186/1471-2350-9-76

Cited by 19 publications

(13 citation statements)

References 38 publications

(51 reference statements)

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“…In 2008, Sieminska et al [32] were not so selective in recruiting smoker individuals, similarly to Nilsson et al [36] who selected daily or occasional smokers. These types of selection may not recruit those smokers that really have a high degree of dependence and are probably those that really suffer from great genetic susceptibility.…”

Section: Discussionmentioning

confidence: 91%

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Association between the STin2 VNTR polymorphism and smoking behavior in oral cancer patients and healthy individuals

et al. 2011

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The serotonergic system may be involved in smoking behavior since the intake of nicotine increases serotonin secretion in the CNS. Moreover, evidence supporting the beneficial effect of selective serotonin reuptake for quitting smoking suggesting that the serotonin transporter (5-HTT) is a plausible target for the understanding and elucidation of smoking behavior. The transcriptional activity of its human gene (SLC6A4) is modulated by a polymorphism described in the second intron, the STin2 VNTR, which thus may interfere with 5-HTT synthesis. In this study was analyzed the polymorphism STin2 VNTR of 60 smokers male patients diagnosed for oral carcinoma, 61 male smokers without cancer and 65 non-smoker healthy blood donors. The STin2. 9 allele carriers were more present in smoker groups (with cancer and without cancer, respectively) than in the non-smoker (OR = 7.11, 95% CI = 0.83-60.91 and OR = 24.73; IC 95% = 3.17-192.66). Conversely, individuals carrying allele 10 were more prevalent in non-smokers compared with smokers (oral cancer patients and individuals without cancer, respectively), showing a protective factor of this allele (OR = 0.56; 95% CI = 0.24-1.33 and OR = 0.46; 95% CI = 0.20-1.07). This is the first report of a study assessing the importance of STin2 VNTR smoking behavior in Brazilian individuals and the association of STin2. 9 allele carriers in nicotine dependence. It is suggested that individuals with low serotonin concentration in the central nervous system, probably due to the presence of the allele for high expression of 5-HTT,especially STin2. 9, were more susceptible to nicotine dependence. Moreover, individuals with the 10 allele might have less risk for nicotine dependence.

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Section: Discussionmentioning

confidence: 91%

“…However, some research, such as the pioneer study by Lerman et al [31], did not report association of smoking behavior with the 5-HTTLPR polymorphism [32][33][34].…”

Section: Discussionmentioning

confidence: 97%

Association between the STin2 VNTR polymorphism and smoking behavior in oral cancer patients and healthy individuals

et al. 2011

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“…The relationship between the 5HTT gene and dependence has been widely studied and the short allele of 5HT system has received considerable attention in addiction. Although the findings remain equivocal in other studies, it showed no evidence for association [24,27,28], while in some studies a positive association was found [6,29]. Some recent evidences indicate that the association of addiction with short allele may be different in men and women, while it was observed to be homozygote for the short allele among males, this was heterozygote among women.…”

Section: Discussionmentioning

confidence: 40%

“…Some studies found the evidence for the role of serotonin in autism and addiction. In contrast with these findings, some other studies failed to demonstrate an association between serotonin transporter gene polymorphism and the personality traits at risk for substance abuse and autism [6,10,23,24]. Based on the above-mentioned reasons, the present study designed to investigate the hypothesis that the frequency of the "low activity" S allele might be higher in the opioid addiction, when compared with non-addiction people.…”

Section: Introductionmentioning

confidence: 72%

Frequency of Serotonin Transporter Promote Gene Polymorphism in Opioid Addicts

Nazari¹,

Ghasemi²,

Mansourabadi³

2016

J Addict Res Ther

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Background: The human serotonin transporter promoter (5-HTT) gene genotype was previously reported to be associated with temperament and personality traits at risk for substance abuse in the subjects with antisocial behaviour. Association studies of polymorphism in the promoter region of this gene in addiction have shown conflicting results. A common 44-base pair insertion/deletion polymorphism in the region of 5-HTT has been observed. This biallelic functional polymorphism designated long (L) and short (S) promotors, which affect 5-HTT gene expression since the short variant is associated with lower transcriptional activity. Since there is strong evidence of a disturbance in brain serotonergic transmission among antisocial, impulsive, anxiety, and different kinds of addiction, the purpose of present study was to evaluate the frequency of these genotypes among adolescents with opioid addiction.

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“…Araştırmacılar bunun ana nedeninin çalışmalarda ki örneklerin heterojenitesinden kaynaklanan kısıtlılıklar olduğunu ifade etmişlerdir. [50][51] …”

Section: Serotonerjik Sistem Ile İlgili Genlerunclassified

Sigara Bagimliliginin Genetigi

Karakülah¹,

Şengül²

2014

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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ÖzetSigara birçok hastalığın sebepleri arasındadır ve her yıl 5 milyon insanın ölümüne neden olarak, en önemli ölüm nedenleri arasında yer almaktadır. Bağımlılık, sigara kullanımının yol açtığı en önemli sendromlardandır ve içerdiği nikotin ile ilişkilendirilmiştir. Sigara bağımlılığının nedenleri farklı bileşenleri ile yoğun bir şekilde araştırılmıştır. Epidemiyolojik, farmakolojik, nörobiyolojik ve genetik çalışmalar başlıca çalışma alanlarıdır. Sigara ve nikotin bağımlılığının genetiği 50 yıldır çalışılmak-tadır. Öncelikle, ikiz, aile ve evlat edinme çalışmaları sigara bağımlılığında genetik geçişin olduğunu göstermiştir. Moleküler genetik çalışmalarında içilen sigara miktarı ve nikotin ile aday genler arasında ilişkili olduğu gösterilmiştir. Bağımlılığın yüksek derecede kalıtsal bir hastalık olması, pozisyonel genetiği kullanarak şüphelenilen genlerin aydınlatılmasına çalışılması için birçok çalış-manın yapılmasını tetiklemiştir. Sigara bağımlılığı genetik diseksiyonu için aday gen çalışmaları da ayrıca kullanılmaktadır. Bu iki yaklaşımın son 20 yılda hastalık patofizyolojisini anlamamızda önemli etkisi olmuştur. Sigara bağımlılığında tüm genomun incelendiği ilişkilendirme çalışmaları ve kopya sayısı değişikliklerinin tespiti de yakın gelecekte önemli katkı sağlayabilecektir. Yeni çalışmalar, epigenetik mekanizmaların veya DNA'nın kimyasal belirteçlerinin ve onu çevreleyen histon proteinlerinin yaşam boyu değişken olduğunu ve çevresel faktörler tarafından değiştirilebileceğini göster-miştir. Epigenetik mekanizmalar, çevresel koşulların şizofreniye etkisini açıklayan cazip bir molekü-ler hipotez olmuştur. Bu yazıda, klasik genetik çalışmalardan yeni epigenetik yaklaşımlara kadar sigara bağımlılığındaki genetik çalışmaların gelişimi gözden geçirilmiştir.Anahtar sözcükler: Sigara, bağımlılık, genetik, epigenetik. AbstractTobacco smoking is associated with many diseases causing 5 million deaths per year worldwide and is regarded as one of the leading causes of death. Addiction is of the most notorious tobacco-related syndrome and is mainly attributed to nicotine. The causes of tobacco smoking addiction were intensively investigated with several components. Epidemiologic, pharmacologic, neurobiological and genetic studies were the main study topics. Genetic studies of smoking and nicotine dependence has been studied for 50 years. Twin, family and adoption studies show evidence for genetic effects on smoking and nicotine dependence. Molecular genetic analyses have identified genes associated with the amount smoked and nicotine dependence. The high heritability of addiction has stimulated much work aimed at identifying susceptibility genes using positional genetics. Candidate gene approaches are also being used for the genetic dissection of smoking addiction. These two approaches had a major impact on our understanding of disease pathophysiology in last 2 decades. Recent work indicates that epigenetic mechanisms or the chemical markings of the DNA and the surrounding histone proteins remain labile through the lifes...

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Lack of association between serotonin transporter gene polymorphism 5-HTTLPR and smoking among Polish population: a case-control study

Cited by 19 publications

References 38 publications

Association between the STin2 VNTR polymorphism and smoking behavior in oral cancer patients and healthy individuals

Association between the STin2 VNTR polymorphism and smoking behavior in oral cancer patients and healthy individuals

Frequency of Serotonin Transporter Promote Gene Polymorphism in Opioid Addicts

Sigara Bagimliliginin Genetigi

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