Lack of association between paraoxonase-1 Q192R polymorphism and rheumatoid arthritis in southeast Iran

Hashemi, Mohammad; Moazeni‐Roodi, Abdolkarim; Fazaeli, Asghar; Sandoughi, Mahnaz; Bardestani, G. R.; Kordi-Tamandani, Dor Mohammad; Ghavami, Saeid

doi:10.4238/vol9-1gmr728

Cited by 89 publications

(52 citation statements)

References 31 publications

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“…The local Ethics Committee of the Zahedan University of Medical Sciences approved the project, and written informed consent was obtained from all participants. Genomic DNA was extracted from whole blood samples, as described previously (Hashemi et al, 2010a). SNP genotyping of P2X7R was performed using tetra-amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR), which is a simple and rapid method for detecting SNP (Hashemi et al, 2010b.…”

Section: Methodsmentioning

confidence: 99%

Association of P2X7 gene polymorphisms with susceptibility to pulmonary tuberculosis in Zahedan, Southeast Iran

Bahari

Hashemi²,

Taheri³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Susceptibility to tuberculosis may be influenced by variations in human genes. The P2X7 receptor is an ATP-gated cation channel expressed in immune cells, and it influences the release of proinflammatory cytokines from monocytes and macrophages. In the present study, we aimed to evaluate the impact of P2X7 gene rs2393799 (-762T/C) and rs1718119 (Thr348Ala) polymorphisms on patient susceptibility to pulmonary tuberculosis (PTB) in a sample of the Iranian population. This case-control study was performed using 150 PTB cases and 150 controls. P2X7 receptor polymorphisms were determined using tetra-amplification refractory mutation system-polymerase chain reaction. Genotype and allelic frequencies of the rs2393799 variant P2X7 gene polymorphisms in pulmonary tuberculosis within the P2X7 gene were significantly higher in the PTB patients than in the healthy controls. The genotypes were CC in 71, CT in 54, and TT in 25 PTB patients. The genotypes were CC in 104, CT in 40, and TT in 6 healthy controls. The results indicate a significant association between rs2393799 polymorphism of the P2X7 gene and susceptibility to PTB (CT vs CC: OR = 6.5, 95%CI = 2.5-16.9, P < 0.0001; TT vs CC: OR = 3.3, 95%CI = 1.2-8.9, P = 0.018; TC+TT vs CC: OR = 2.56, 95%CI = 1.59-4.12, P < 0.0001). The rs2393799 T allele is a risk factor for predisposition to PTB (OR = 2.53, 95%CI = 1.73-3.71, P < 0.0001). No association between the rs1718119 polymorphism and PTB was found. In conclusion, the rs2393799 polymorphism in the P2X7 gene may contribute to patient susceptibility to PTB in our study population.

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Section: Methodsmentioning

confidence: 99%

Association of P2X7 gene polymorphisms with susceptibility to pulmonary tuberculosis in Zahedan, Southeast Iran

Bahari

Hashemi²,

Taheri³

et al. 2013

Genet. Mol. Res.

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“…The SNPs replace a nucleotide with another nucleotide in gene structure. When SNPs arise within a gene or in a regulatory region near a gene, they may play a direct role in disease by affecting the gene's function (14,15). If a SNP take place in coding regions of genes, it causes replacement of an amino acid in a protein structure with another amino acid, which results in the alteration of protein activity (16).…”

Section: Discussionmentioning

confidence: 99%

Association Between A561C Polymorphism of E-Selectin Gene and Coronary Arterial Disease in Southeastern Iranian Population

et al. 2013

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Background: Numerous factors including genetic factors play a role in pathogenesis of coronary atherosclerosis. It has been reported that polymorphisms of genes encoding adhesion molecules are associated with atherosclerosis. Objectives: The present research aimed to evaluate A561C polymorphism of the E-selectin gene in patients with coronary arterial diseases (CAD). Materials and Methods: Eighty seven CAD patients and 93 age-and sex-matched control subjects were enrolled in this research. The polymorphism of A561C in the E-selectin gene was defined by polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP). Results: The prevalence's of AA, AC and CC genotypes were 55.2%, 24.1% and 20.7% in CAD patients and 51.6%, 40.9% and 7.5% in the control subjects, respectively. The frequencies of the C allele were significantly higher in CAD patients compared with control groups (P < 0.05). Logistic regression analysis revealed a significant association between the C allele and the risk of CAD (OR = 1.61, 95%CI = 1.03-2.51). Conclusions: Our results displayed that presence of C allele at position 561 E-selection gene is associated with increased risk of atherosclerosis disease in the southeastern Iranian population. This polymorphism may be able to affect leukocyte-endothelial interactions, which may account for the pathogenesis of atherosclerosis.

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“…The formation of free radicals is a normal outcome of a variety of essential biochemical reactions and can occur at elevated rates under pathophysiological circumstances (12,13). The physiological role of antioxidants is to prevent damage to (16,17). It has been well documented that the two common coding region polymorphisms of the gene PON1 (L55M and Q192R) lead to changes of both the level and activity of the enzyme (18,19).…”

Section: Discussionmentioning

confidence: 99%

Serum paraoxonase and arylesterase activities in metabolic syndrome in Zahedan, southeast Iran

Hashemi

Kordi-Tamandani

Sharifi

et al. 2011

European Journal of Endocrinology

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Objective: Paraoxonase (PON) is associated with high-density lipoprotein and protects serum lipid from oxidation. The aim of this study was to determine serum PON, arylesterase (ARE) activities, and total antioxidant capacity (TAC) in metabolic syndrome (MES). Methods: This case-control study was performed on 106 patients with MES and 231 healthy subjects. Serum PON and ARE activities were determined spectrophotometrically. TAC was determined using ferric reducing ability of plasma assay. Results:The results showed that serum PON activity was significantly lower in patients with MES (69.62G59.86 IU/l) than healthy subjects (91.64G77.45 IU/l) (P!0.05). The serum ARE activity in MES and normal subjects were 45.23G23.24 and 65.69G31.10 kU/l respectively. The ARE activity was significantly lower in patients with MES than normal subjects (P!0.0001). No significant differences were observed between MES and normal subjects regarding TAC. Conclusion: The lower PON and ARE activities in MES may be considered an independent risk factor for cardiovascular disease, which remains to be cleared.

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Lack of association between paraoxonase-1 Q192R polymorphism and rheumatoid arthritis in southeast Iran

Cited by 89 publications

References 31 publications

Association of P2X7 gene polymorphisms with susceptibility to pulmonary tuberculosis in Zahedan, Southeast Iran

Association of P2X7 gene polymorphisms with susceptibility to pulmonary tuberculosis in Zahedan, Southeast Iran

Association Between A561C Polymorphism of E-Selectin Gene and Coronary Arterial Disease in Southeastern Iranian Population

Serum paraoxonase and arylesterase activities in metabolic syndrome in Zahedan, southeast Iran

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