Lack of association between objectively assessed sleep disorders and inflammatory markers among kidney transplant recipients

Fornadi, Katalin; Lindner, Anett; Czira, Maria E.; Szentkirályi, András; Lázár, Alpár S.; Zoller, Rezső; Turányi, Csilla Zita; Véber, Orsolya Ágnes; Novák, Márta; Mucsi, István; Molnar, Miklos Z.

doi:10.1007/s11255-011-0095-7

Cited by 31 publications

(21 citation statements)

References 42 publications

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“…It must be recognized that several predominantly negative studies, finding no association between sleep and immune markers, have also been published. For example, one study found no elevations among patients with kidney disease 139. Another study by Taheri et al found no association between sleep and CRP,126 a negative finding that was also demonstrated by Haack et al79 Tuomilehto et al also found no association between sleep and both CRP and IL-6 in the context of a lifestyle intervention (which may have overshadowed any association) 140.…”

Section: Limitations Of Existing Studiesmentioning

confidence: 93%

Sleep duration, cardiovascular disease, and proinflammatory biomarkers

Grandner¹,

Sands-Lincoln²,

Pak³

et al. 2013

NSS

197

132

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Habitual sleep duration has been associated with cardiometabolic disease, via several mechanistic pathways, but few have been thoroughly explored. One hypothesis is that short and/or long sleep duration is associated with a proinflammatory state, which could increase risk for cardiovascular and metabolic diseases. This hypothesis has been largely explored in the context of experimental sleep deprivation studies which have attempted to demonstrate changes in proinflammatory markers following acute sleep loss in the laboratory. Despite the controlled environment available in these studies, samples tend to lack generalization to the population at large and acute sleep deprivation may not be a perfect analog for short sleep. To address these limitations, population based studies have explored associations between proinflammatory markers and habitual sleep duration. This review summarizes what is known from experimental and cross-sectional studies about the association between sleep duration, cardiovascular disease, and proinflammatory biomarkers. First, the association between sleep duration with both morbidity and mortality, with a focus on cardiovascular disease, is reviewed. Then, a brief review of the potential role of proinflammatory markers in cardiovascular disease is presented. The majority of this review details specific findings related to specific molecules, including tumor necrosis factor-α, interleukins-1, -6, and -17, C-reactive protein, coagulation molecules, cellular adhesion molecules, and visfatin. Finally, a discussion of the limitations of current studies and future directions is provided.

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Section: Limitations Of Existing Studiesmentioning

confidence: 93%

Sleep duration, cardiovascular disease, and proinflammatory biomarkers

Grandner¹,

Sands-Lincoln²,

Pak³

et al. 2013

NSS

197

132

View full text Add to dashboard Cite

show abstract

“…In contrast, Fornadi et al did not find any significant difference in TNF-α level in 100 randomly selected kidney transplant patients. 16 Several studies examined fibrinogen, an acute-phase reactant, in OSA patients. Although some studies showed increased levels in severe OSA, [17][18][19] others showed less straightforward results, without increase in fibrinogen or changes after continuous positive airway pressure (CPAP) treatment.…”

Section: Inflammatory Biomarkers Play a Key Role In The Pathogenesis mentioning

confidence: 99%

Biomarkers for Sleep Apnea

2017

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Obstructive sleep apnea (OSA) is a substantial medical problem with significant morbidity, both in the pediatric population and in adults. The gold standard for diagnosis and assessment of response to treatment has been overnight polysomnography. However, it is costly, time-consuming, and inconvenient to the patients. Thus, there is an emerging need for markers that would identify patients with OSA, especially those at risk for complications who require closer surveillance and more aggressive treatment. In recent years, a large number of studies have been conducted to search for the ideal biomarker in the blood and other body fluids, mainly urine, saliva, and exhaled breath. We present a literature review of current literature on biomarkers of OSA. We conclude that the ideal sole biomarker has not been found yet, but several markers have the potential to serve as screening tools; an array of markers, as well as analysis of epigenetic factors, could serve in diagnosis and in tailoring the best specific treatment for the single patient.

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“…Recently, growing evidence shows that OSA is associated with renal disorders, especially chronic kidney disease (CKD) and end-stage renal disease (ESRD) [3][4][5][6][7][8]. Patients with impaired renal function, CKD, ESRD, even kidney transplantation, exhibit a high prevalence of OSA [3][4][5], and inversely, OSA is independently correlated with increased urinary albumin excretion and loss of kidney function [7,8].…”

Section: Introductionmentioning

confidence: 99%