Lack of association between monocyte protein-1 (MCP-1) –2518 A &gt; G chemoattractant and C–C chemokine receptor 2 (CCR2) Val64Ile polymorphisms and multiple sclerosis in a Tunisian population

Messadi, Amira; Fekih-Mrissa, Najiba; Kallel, Amani; Bouguerra, Chaker; Sediri, Yousra; Zaweli, J.; Laayouni, S.; Nciri, Brahim; Yedeas, Mondher; Mrissa, Ridha; Jemaa, Riadh; Kaabachi, Naziha; Gritli, Nasreddine

doi:10.1016/j.jocn.2010.03.022

Cited by 8 publications

(6 citation statements)

References 24 publications

(31 reference statements)

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“…In an association study of rs1024611 with the risk of MS, no correlation was found between genotype and the clinical disease course of MS, including a comparison of carriers of mRNA expression and CCL2 secretion in German patients . Another genetic study of rs1024611 in a Tunisian population found no difference between MS patients and healthy controls in the allelic or genotypic frequencies . Similarly, this study of a CCL2 SNP (rs1024611), as well as other statistical analyses of genetic interactions showed no association with MS or other disease courses consisting of IDD in a Korean population.…”

Section: Introductionsupporting

confidence: 48%

“…Another study attempted to define the genetic interrelation of CCL clusters with MS by various analytic methods, including the study of haplotypes and meta‐analysis in a large sample composed of Nordic populations . In addition, several studies have focused on the association of the polymorphism rs1024611 of CCL2 with the risk of MS and autoimmune diseases .…”

Section: Introductionmentioning

confidence: 99%

“…Another genetic study of rs1024611 in a Tunisian population found no difference between MS patients and healthy controls in the allelic or genotypic frequencies . Similarly, this study of a CCL2 SNP (rs1024611), as well as other statistical analyses of genetic interactions showed no association with MS or other disease courses consisting of IDD in a Korean population.…”

Section: Introductionmentioning

confidence: 99%

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No association between CCL2 gene polymorphisms and risk of inflammatory demyelinating diseases in a Korean population

et al. 2014

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Inflammatory demyelinating disease (IDD), which includes multiple sclerosis (MS) and neuromyelitis optica (NMO), affects the central nervous system. Chemokine ligand 2 (CCL2/MCP-1) is considered an important contributor to the development or progression of IDD. However, genetic association studies of Asian populations are lacking. In this study, we investigated a possible association between CCL2 polymorphisms (rs1024611, rs28730833, and rs2857657) and a Korean population (178 IDD patients and 237 healthy controls) using multiple logistic regression models. However, we did not find any association, which was consistent with other studies in Caucasian populations. In conclusion, our results suggest that CCL2 variants may not contribute to the pathogenesis of IDD.

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Section: Introductionsupporting

confidence: 48%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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No association between CCL2 gene polymorphisms and risk of inflammatory demyelinating diseases in a Korean population

et al. 2014

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“…Several studies have focused on the association between the polymorphism rs1024611 of the CCL2 with the risk of autoimmune diseases and MS [40,[48][49][50][51]. Seven polymorphisms of CCL2 were evaluated (rs1024611, rs2857656, rs4586, rs13900, rs28730833, rs3917887, and rs2857657) and none of these variants revealed any association with inflammatory demyelinating diseases, as well as MS or NMO in a Korean population [40].…”

Section: Non-hla Genetic Factorsmentioning

confidence: 99%

Epidemiological, clinical, and immunological characteristics of neuromyelitis optica: A review

Pereira

Reiche

Kallaur

et al. 2015

Journal of the Neurological Sciences

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The aim of this study was to review the epidemiological and clinical characteristics of neuromyelitis optica (NMO) and the immunopathological mechanisms involved in the neuronal damage. NMO is an inflammatory demyelinating autoimmune disease of the central nervous system that most commonly affects the optic nerves and spinal cord. NMO is thought to be more prevalent among non-Caucasians and where multiple sclerosis (MS) prevalence is low. NMO follows a relapsing course in more than 80-90% of cases, which is more commonly in women. It is a complex disease with an interaction between host genetic and environmental factors and the main immunological feature is the presence of anti-aquaporin 4 (AQP4) antibodies in a subset of patients. NMO is frequently associated with multiple other autoantibodies and there is a strong association between NMO with other systemic autoimmune diseases. AQP4-IgG can cause antibody-dependent cellular cytotoxicity (ADCC) when effector cells are present and complement-dependent cytotoxicity (CDC) when complement is present. Acute therapies, including corticosteroids and plasma exchange, are designed to minimize injury and accelerate recovery. Several aspects of NMO pathogenesis remain unclear. More advances in the understanding of NMO disease mechanisms are needed in order to identify more specific biomarkers to NMO diagnosis.

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“…Also, the relapsing/remitting phase of MS was statistically longer in genotype VI than in genotype II, whereas the frequency of secondary progressive MS was statistically higher in genotype VV than in genotype VI for the same polymorphism [86] . A study by Messadi et al [87] verified that in MCP-1 -2518 A>G and CCR2 Val64Ile polymorphisms (using PCR-RFLP analysis) neither the MCP-1 -2518G variant nor the CCR2 64Ile variant contributed to the risk of MS in a Tunisian population [87] . Galimberti et al [88] reported the frequency of C/T and C/A in both promoter and coding sequences of CCL22 and the C/T SNP in the promoter of CCL17, and they found a decreased frequency of the A allele of the CCL22 C/A SNP as well as of the T allele of the CCL17 C/T SNP in patients compared to controls.…”

Section: Ms and Genetic Variationsmentioning

confidence: 94%

Significant Role(s) of CXCL12 and the SDF-1 3′A Genetic Variant in the Pathogenesis of Multiple Sclerosis

Karimabad

Falahati-Pour

Hassanshahi³

2016

Neuroimmunomodulation

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Both cellular and molecular components of the immune system are among the substantial factors involved in the pathogenesis of multiple sclerosis (MS). Accumulating evidence confirms that chemokines, as the main members of the immune system, play key roles in the regulation of immune responses. Immune system genetic parameters are believed to influence the onset of immune system-related diseases. Regarding the significant role of the CXCR4/CXCL12 axis in cell differentiation and survival and homing of hematopoietic progenitors to the bone marrow and regulation of neuronal progenitor cell migration in the central nervous system (CNS), genetic factors can cause an increased expression of CXCL12 and induce a vigorous immune response against CNS antigens in MS patients. Previous studies have indicated that the expression of CXCL12 could be affected by its polymorphisms at position +801 at the region of the CXCL12 3′A genetic variation. Finally, CXCL12 seems to be involved in the cellular part of the events that take place in the CNS, and therefore it could be considered as a target in MS therapies. Thus, this review was aimed to describe the recent progress in understanding the role of CXCL12 in MS, with an emphasis on CXCL12 serum concentrations and its gene polymorphism at position +801.

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Lack of association between monocyte protein-1 (MCP-1) –2518 A > G chemoattractant and C–C chemokine receptor 2 (CCR2) Val64Ile polymorphisms and multiple sclerosis in a Tunisian population

Cited by 8 publications

References 24 publications

No association between CCL2 gene polymorphisms and risk of inflammatory demyelinating diseases in a Korean population

No association between CCL2 gene polymorphisms and risk of inflammatory demyelinating diseases in a Korean population

Epidemiological, clinical, and immunological characteristics of neuromyelitis optica: A review

Significant Role(s) of CXCL12 and the SDF-1 3′A Genetic Variant in the Pathogenesis of Multiple Sclerosis

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