Lack of association between maternal periodontal status and adverse pregnancy outcomes: a multicentric epidemiologic study

Abati, S.; Villa, Alessandro; Cetin, Irene; Dessole, Salvatore; Lugliè, Pietrina Francesca; Strohmenger, L; Ottolenghi, Livia; Campus, Guglielmo

doi:10.3109/14767058.2012.733776

Cited by 39 publications

(34 citation statements)

References 22 publications

(20 reference statements)

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“…These findings are consistent with those of Wood et al, Bassani et al, Abati et al, Souccar et al, and other authors who found no association between periodontitis and preterm labor. 32,33,34,35 Conclusively, we could not establish an association between chronic periodontitis and preterm labor based on the measured IL-17 levels in GCF and placental tissue samples in the present study. Despite limitations, including a small sample size and lack of intervention, this is a pioneer case-control study that can be added to the database of evidence-based research in this particular field of periodontology.…”

Section: Discussioncontrasting

confidence: 66%

“…24,25,26,27 Some studies have demonstrated positive correlations, while others have not. 28,29,30,31,32,33,34,35 Although these results seem contradictory, factors such as race, geographical location, and socioeconomic standards have not been adequately adjusted for. Consequently, studies conducted in the United States and Europe differ from those conducted in Latin America or Africa, mainly due to a lack of adjustment for socio-economic factors, such as accessibility to adequate and affordable health care.…”

Section: Discussionmentioning

confidence: 99%

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Gingival Crevicular Fluid and Placental Tissue Levels of Interleukin-17 as a Possible Marker for Preterm Labor in Patients with Chronic Periodontitis

Gamal

Agoor

Shaker

et al. 2017

Perio J

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Background: The present study was conducted to evaluate the levels of interleukin (IL) -17 in gingival crevicular fluid (GCF) and placental tissue samples of pregnant females as a possible marker in determining whether or not an association exists between chronic periodontitis and preterm labor. Methods: This case-control study included a random sample of 40 female patients, aged 18 to 35 years, who were assigned to one of the following four groups (10 subjects each): group 1 included patients who underwent spontaneous preterm birth (PB) and were diagnosed with chronic periodontitis upon clinical examination (preterm/periodontitis); group 2 included patients who underwent spontaneous PB and who had a healthy periodontium upon clinical examination (preterm/healthy periodontium); group 3 included patients who underwent spontaneous normal term birth and were diagnosed with chronic periodontitis upon clinical examination (term/periodontitis); and group 4 included patients who underwent spontaneous normal term birth and who had a healthy periodontium upon clinical examination (term/healthy periodontium). GCF and placental tissue samples were obtained from each patient and IL-17 levels were measured using enzyme-linked immunosorbent assay (ELISA). Results: GCF levels of IL-17 were significantly higher (P=0.010) in patients with chronic periodontitis compared to those with a healthy periodontium. No significant differences were observed in IL-17 levels in placental tissue samples of all study groups. Conclusion: An association between chronic periodontitis and preterm labor could not be established based on IL-17 levels measured in the present study.

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Section: Discussioncontrasting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Gingival Crevicular Fluid and Placental Tissue Levels of Interleukin-17 as a Possible Marker for Preterm Labor in Patients with Chronic Periodontitis

Gamal

Agoor

Shaker

et al. 2017

Perio J

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“…Previous studies focusing solely on the PPROM population of preterm births are lacking. However, studies involving the PPROM population reported the prevalence of periodontal disease in a similar cohort of women to be around 50% or more (Abati et al., ; Radnai et al., ; Santos‐Pereira et al., ). Based on these observations, a 25% prevalence in the control group and a 50% prevalence in the PPROM group were expected.…”

Section: Methodsmentioning

confidence: 99%

Association between periodontal disease and preterm prelabour rupture of membranes

Radochová

Štěpán

Musilová

et al. 2019

J Clinic Periodontology

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Objective Periodontal disease is a possible contributing factor to preterm delivery. The aim of this study was to compare the periodontal status of women with preterm prelabour rupture of membranes (PPROM) and women with uncomplicated singleton pregnancies. Patients and Methods Seventy‐eight women with PPROM at gestational ages between 24 + 0 and 36 + 6 weeks and 77 healthy women with uncomplicated pregnancies, matched for gestational age at sampling without preterm birth, were included in this study. All women underwent evaluation of periodontal and oral hygiene status. Results Women with PPROM had higher gingival and plaque indexes in crude analysis (gingival index: median 0.80 versus 0.20; p < 0.0001; plaque index: median 0.80 versus 0.10; p < 0.0001), even after adjustment for smoking status (p < 0.0001 and p < 0.0001). Mean clinical attachment loss (CAL) and probing pocket depth (PPD) values were higher in women with PPROM in the crude analysis (CAL: median 2.3 mm versus 1.8 mm; p < 0.0001; PPD: median 2.3 mm versus 1.8; p < 0.0001), as well as after adjustment for smoking status (p < 0.0001 and p < 0.0001). Conclusions Pregnant women with PPROM residing in central Europe had worse periodontal status than women with uncomplicated pregnancies.

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“…Abati et al . reported that periodontitis and APO have no significant association, based on a multicentric epidemiologic study . Due to variations in the risk factors for APO, we should be careful to understand the difference between correlation and causation between periodontal diseases and APO.…”

Section: Epidemiological Resultsmentioning

confidence: 98%

Periodontal diseases and adverse pregnancy outcomes

Komine‐Aizawa

Aizawa

Hayakawa

2018

J of Obstet and Gynaecol

108

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From last decade of the 20th century, numerous epidemiological studies and intervention trials have attempted to prove the relationships between maternal periodontal diseases and adverse pregnancy outcomes (APO). Periodontal diseases are considered a risk factor for APO, including preterm birth, fetal growth restriction, low birthweight, pre-eclampsia and gestational diabetes. However, the efficacy of periodontal treatment during pregnancy is controversial. Two pathogenic mechanisms might explain the potential effect of periodontal diseases on pregnancy outcomes. First, periodontal bacteria originating in the gingival biofilm directly affect the feto-placental unit subsequent to bacteremia. Second, inflammatory mediators secreted by the subgingival inflammatory site are carried to the feto-placental unit, where they then cause an inflammatory response. To elucidate these mechanisms, many researchers have been investigating the use of experimental animal models and in vitro models. In the present review, we summarize the current literature on the relationship between periodontal diseases and APO from epidemiological studies, animal models studies and in vitro studies, and speculate on the possible mechanism of periodontal diseases affecting pregnancy outcomes.

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Lack of association between maternal periodontal status and adverse pregnancy outcomes: a multicentric epidemiologic study

Abstract: Our data failed to demonstrate the association between periodontitis and an adverse pregnancy outcome such as preterm birth, low birth weight, preeclampsia, intrauterine growth restriction, and premature rupture of membranes.

Cited by 39 publications

References 22 publications

Gingival Crevicular Fluid and Placental Tissue Levels of Interleukin-17 as a Possible Marker for Preterm Labor in Patients with Chronic Periodontitis

Gingival Crevicular Fluid and Placental Tissue Levels of Interleukin-17 as a Possible Marker for Preterm Labor in Patients with Chronic Periodontitis

Association between periodontal disease and preterm prelabour rupture of membranes

Periodontal diseases and adverse pregnancy outcomes

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