Lack of Association between <b><i>NYD-SP18</i></b> Variant and Obesity. The Health Alcohol and Psychosocial Factors in Eastern Europe Study

Abstract

Aim: To replicate the finding that the polymorphism rs6971091 within the NYD-SP18 gene is associated with body mass index (BMI). Method: We analysed data of 29,284 adults (46.2% of males, mean age 58.9 (SD 7.3), mean BMI 28.6 (5.0 kg/m²)) examined within the Health Alcohol and Psychosocial Factors in Eastern Europe study in the Czech Republic, Poland, Lithuania and Russia. Results: BMI did not differ by rs6971091 genotype. In men, the mean BMI (SEs) in GG, GA and AA carriers were 27.8 (0.05), 27.9 (0.06) and 27.9 (0.14) kg/m², respectively, (p = 0.26); in women, the corresponding values were 29.2 (0.06), 29.1 (0.07) and 29.1 (0.16), p = 0.57. In Czech subjects (n = 6,752), for whom the FTO rs17817449 genotype was available, there was no interaction between the NYD-SP18 and FTO polymorphisms in determination of BMI. Adjustment for age, energy and fat intake and physical activity did not materially change the results. There was no association of the NYD-SP18 genotype with waist-hip ratio. Conclusion: This study in a large Slavonic population sample suggests that the rs6971091 variant within the NYD-SP18 gene is not an important determinant of obesity in middle-aged persons.

Body Adiposity Changes After Lifestyle Interventions in Children/Adolescents and the NYD-SP18 and TMEM18 Variants

“…To date, the putative association between the NYD-SP18 rs6971091 polymorphism and BMI/body weight has been reported in 2 [ 4 , 6 ] out of 3 previous studies [ 4 , 6 , 7 ]. Although we did not find an association of this polymorphism with BMI values in our study, one of the obesity markers – abdominal skinfolds value – was significantly higher in AA homozygotes both before and after the intervention.…”

“…These results were partially confirmed by the Czech Post-MONICA study, in which an association between the NYD-SP18 polymorphism and BMI was detected in males but not in females [ 6 ]. Results from the large HAPIEE study of elderly subjects detected no significant association between the NYD-SP18 polymorphism and BMI [ 7 ].…”

“…NYD-SP18 is also associated with the production of testosterone and, therefore, may affect exercise-based muscle formation and development, which may be more pronounced in males. This finding potentially explains the sex-specific effect of NYD-SP18 on BMI observed in the Czech Post-MONICA study, which included males age 25–64, and the HAPIEE study, which included males aged over 45 years [ 7 ]. Finally, it has been suggested that this variant is a significant predictor of body composition changes in overweight/obese females after a short-term lifestyle intervention [ 8 ].…”