Lack of association between lipaemia and central adiposity in subjects with an atherogenic lipoprotein phenotype (ALP)

Minihane, Anne Marie; Khan, Syrah; Talmud, Philippa J.; Williams, D. L.; Wright, John W.; Murphy, Margaret; Griffin, Bruce A.; Williams, Christine M.

doi:10.1038/sj.ijo.0801372

Cited by 13 publications

(14 citation statements)

References 60 publications

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“…15,18 Body fat accumulation, especially that in the abdominal region, was positively associated with hyperinsulinaemia and all surrogate measures of insulin resistance and negatively associated with measures of insulin sensitivity in both the Caucasian and Sikh men. These data support previous studies in Caucasian men 26,30,[39][40][41][42] and Asian Indian men. 8,10,38,43,44 The higher circulating insulin levels associated with greater fat accumulation appeared to have compensated for the loss of insulin sensitivity in the Sikh, as no significant associations between fasted glucose and measures of adiposity were observed.…”

Section: Discussionsupporting

confidence: 83%

“…This supports findings from other groups on Caucasian subjects. 21,22,30,[45][46][47][48] However, it was observed that the Caucasian men in the present study had a significant positive associations between fasting glucose and BMI, waist and subscapular. Although the Sikh men had higher insulin resistance than the Caucasian men, they also presented with higher fasted insulin, which could have contributed to the lack of relationship between glucose and body fat distribution.…”

Section: Discussioncontrasting

confidence: 50%

“…These data support findings from other studies performed on Caucasian men, 21,22,[56][57][58][59] although not all. 30,31 However, the expected positive association between waist (or any other measure of adiposity) and circulating TAG was not observed in the Sikh men. In fact there was a trend to a negative association between measures of adiposity and plasma TAG, which almost reached significance for subscapular skinfold thickness (r ¼ À0.246, P ¼ 0.07).…”

Section: Discussionmentioning

confidence: 99%

“…Two previous studies performed on Caucasian men, who present with an ALP, also reported a lack of, or negative association between BMI and fasting and postprandial chylomicron-TAG responses. 30,31 In both studies, apoE genotyping was performed and it was reported that the Caucasian men with ALP had a higher prevalence of apoE4 genotypes. 30,31 Minihane and colleagues reported that 39% of the ALP group carried the apoE4 allele, which is higher than the population prevalence of 25-27%.…”

Section: Discussionmentioning

confidence: 99%

“…However, while similar relationships might be expected to be observed in Caucasian men presenting with the dyslipidaemia of the metabolic syndrome (atherogenic lipoprotein phenotype (ALP)), recent studies have reported otherwise. 30,31 Studies performed in Asian Indian migrants investigating relationships between measures of adiposity, lipid and insulin levels are limited. 10 It therefore seems prudent to investigate the associations between measures of adiposity, insulin resistance and lipid levels in a migrant Indian Asian group.…”

Section: Introductionmentioning

confidence: 99%

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Lack of association between central adiposity and lipaemia in UK Sikh men

et al. 2003

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OBJECTIVE: To determine whether the positive statistical associations between measures of total and regional adiposity and measures of glucose, insulin and triacylglycerol (TAG) metabolism reported in Caucasian men, are also observed in UK Sikhs. DESIGN: A matched cross-sectional study in which each volunteer provided a blood sample after a 12-h overnight fast and had anthropometric measurements taken. SUBJECTS: A total of 55 healthy Caucasian and 55 healthy UK Sikh men were recruited. The Caucasian and Sikh men were matched for age (48.7710.9 and 48.3710.0 y, respectively) and body mass index (BMI) (26.172.8 and 26.373.2 kg/m 2 , respectively). MEASUREMENTS: Anthropometric measurements were performed to assess total and regional fat depots. The concentrations of plasma total cholesterol, high-density cholesterol (HDL-C), low-density cholesterol (LDL-C) and small dense LDL (LDL3), TAG, glucose, fasting insulin (ins) and nonesterified fatty acids (NEFA) were analysed in fasted plasma. Surrogate measures of insulin resistance (HOMA-IR) and insulin sensitivity (RQUICKI) were calculated from insulin and glucose (HOMA-IR) and insulin, glucose and NEFA (RQUICKI) measurements. RESULTS: The Sikh men had significantly higher body fat, with the sum of the four skinfold measurements (Ssk) (P ¼ 0.0001) and subscapular skinfold value (P ¼ 0.009) higher compared with the Caucasian men. The Sikh volunteers also had characteristics of the metabolic syndrome: lower HDL-C (P ¼ 0.07), higher TAG (P ¼ 0.004), higher % LDL3 (P ¼ 0.0001) and insulin resistance (P ¼ 0.05 ). Both ethnic groups demonstrated positive correlations between insulin and waist circumference (Caucasian: r ¼ 0.661, P ¼ 0.0001; Sikh: r ¼ 0.477, P ¼ 0.0001). The Caucasian men also demonstrated significant positive correlations between central adiposity (r ¼ 0.275, P ¼ 0.04), other measures of adiposity (BMI and suprailiac skinfold) and plasma TAG, whereas the Sikh men showed no correlation for central adiposity (r ¼ 0.019, ns) and TAG with a trend to a negative relationship between other measures (Ssk and suprailiac) which reached near significance for subscapular skinfold and TAG (r ¼ À0.246, P ¼ 0.007). The expected positive association between insulin and TAG was observed in the Caucasian men (r ¼ 0.318, P ¼ 0.04) but not in the Sikh men (r ¼ 0.011, ns). CONCLUSIONS: In the Caucasian men, the expected positive association between plasma TAG and centralized body fat was observed. However, a lack of association between centralized, or any other measure of adiposity, and plasma TAG was observed in the matched Sikh men, although both ethnic groups showed the positive association between centralized body fat and insulin resistance, which was less strong for Sikhs. These findings in the Sikh men were not consistent with the hypothesis that there is a clear causal relationship between body fat and its distribution, insulin resistance, and lipid abnormalities associated with the metabolic syndrome, in this ethnic group.

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