Lack of association between intercellular adhesion molecule-1 (ICAM-1) polymorphisms and polycystic ovary syndrome

Vural, Pervin; Kanmaz-Özer, Müge; Doğru‐Abbasoğlu, Semra; Gedikbaşı, Ali; Çil, Esra; Karadağ, Berrin; Uysal, Müjdat

doi:10.1007/s10815-011-9607-8

Cited by 7 publications

(6 citation statements)

References 32 publications

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“…Some evidence suggests that low-grade chronic inflammation and endothelial dysfunction are involved in the pathogenesis of PCOS 16 and insulin resistance. 17 In this study, we aimed to establish whether progesterone replacement suffices to maintain the endometrium in patients with PCOS in an appropriate state together with the elements that are known to influence the maternal-fetal interaction during the implantation window.…”

Section: Introductionmentioning

confidence: 99%

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Histomorphometric Analysis and Markers of Endometrial Receptivity Embryonic Implantation in Women With Polycystic Ovary Syndrome During the Treatment With Progesterone

et al. 2014

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Literature data indicate that the infertility in women with polycystic ovary syndrome (PCOS) is not only attributed to anovulation but also to endometrial dysfunction. Endometrial biopsies were performed in the proliferative and secretory phases of women with normal cycle and in women with PCOS before and after oral treatment with micronized progesterone. After the treatment, the endometrium of the women with PCOS exhibited a lower number of glands and thicker luminal epithelium compared to the normal women in the secretory phase. In addition, the PCOS group exhibited reduced integrin and MECA-79 immunoexpression during the secretory phase. The expression of E-cadherin was higher in the PCOS and the expression of intercellular adhesion molecule 1 was lower in PCOS, during the secretory and proliferative phases, respectively. Also, there is a negative correlation with MECA-79 and integrin expression and body mass index. Conventional doses of progesterone may not be enough to correct the changes of endometrial histomorphology and the receptive markers of PCOS-bearing women. The obesity may be a factor that interferes with this response.

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Section: Introductionmentioning

confidence: 99%

“…Some evidence suggests that low-grade chronic inflammation and endothelial dysfunction are involved in the pathogenesis of PCOS 16 and insulin resistance. 17…”

Section: Introductionmentioning

confidence: 99%

Histomorphometric Analysis and Markers of Endometrial Receptivity Embryonic Implantation in Women With Polycystic Ovary Syndrome During the Treatment With Progesterone

et al. 2014

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“…9 Ojeda-Ojeda et al 10 demonstrated that ICAM1 common variant K469E was strongly associated with polycystic ovary syndrome in Spain, but it was not a risk factor for polycystic ovary syndrome in other ethnic groups. 11 Furthermore, our recent study is another example of differential association of common variants with a disease in different ethnic backgrounds, an example being MTHFR polymorphism c.677C.T. 12 This variant has been associated with gastroschisis in our population, but it has not shown an effect on gastroschisis in white individuals.…”

Section: Discussionmentioning

confidence: 86%

ICAM1K469E Polymorphism Effect in Gastroschisis Patients

et al. 2018

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Objective: To evaluate the association between a common cell-cell interaction variant, intracellular adhesion molecule 1 (ICAM1) K469E, and gastroschisis risk in Indonesia. Summary of Background Data: Gastroschisis is a congenital disorder characterized by fetal intestines' extrusion outside the body. Several hypotheses have been proposed for gastroschisis, including an impairment in the normal attachment between umbilical cord and umbilical ring. Methods: A total of 48 infants with gastroschisis and 88 ethnicity-matched controls were involved in this study. The ICAM1 K469E polymorphism was analyzed using polymerase chain reaction-restriction fragment-length polymorphisms on genomic DNA. Results: The frequencies of genotypes for ICAM1 K469E in patients were KK, 30 of 48 (63%); KE, 17 of 48 (35%); and EE, 1 of 48 (2%), whereas their frequencies in controls were KK, 48 of 88 (55%); KE, 33 of 88 (37%); and EE, 7 of 88 (8%). Those frequencies were not significantly different between both groups (P ¼ 0.37) with an OR of 1.39 (95% CI, 0.68-2.85). The K469 allele had a frequency of 80% (77 of 96) in patients and 73% (129 of 176) in controls, and the frequency in patients was not significantly higher than that in controls (P ¼ 0.20), with an odds ratio of 1.48 (95% confidence interval, 0.81-2.70). In addition, the frequency of ICAM1 K469 allele in patients with maternal age younger than 25 years was

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“…We did not find an association between Ser128Arg polymorphisms and the risk of developing PCOS in the present sudy, indicating that these polymorphisms alone may not play a major role in the PCOS etiopathogenesis. In addition, we reported recently the lack of association between intercellular adhesion molecule 1 (ICAM1) and vascular adhesion molecule 1 (VCAM1) polymorphisms with PCOS [38,39]. However, the VCAM1 -1591 polymorphism was found to be related with increased triglyceride and decreased HDL-C in PCOS, supporting increased risk for atherosclerosis and cardiovascular disease in PCOS women [39].…”

Section: Discussionmentioning

confidence: 99%

The Ser128Arg polymorphism of E-selectin gene is not associated with polycystic ovary syndrome

Doğru‐Abbasoğlu¹,

Kanmaz-Özer²,

Vural³

et al. 2014

Turk J Bioch

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The Ser128Arg polymorphism of E-selectin gene is not associated with polycystic ovary syndrome [E-selektin genin Ser128Arg polimorfizmi polikistik over sendromu ile ilgili değildir] ABSTRACT Objective: Low-grade chronic inflammation and endothelial dysfunction have important role in the pathogenesis of polycystic ovary syndrome (PCOS). E-selectin is a cell adhesion molecule involved in first attachment and transmigration of leukocytes to activated endothelium in conditions with chronic inflammation. This study examined for the first time the possible association of Ser128Arg (c.561 A>C) single nucleotide polymorphism (SNP) of E-selectin gene with the occurrence of PCOS, and evaluates the relationship between genotypes and clinical/ biochemical characteristics of PCOS. Methods: The Ser128Arg polymorphism of E-selectin gene in DNA from peripheral blood leukocytes of 169 PCOS patients and 259 healthy control women were investigated by real-time PCR combined with melting curve analysis using fluorescence-labeled hybridization probes. Results: It was found that insulin resistance (IR) was present in 85 (50%) of women with PCOS. Additionally, insulin (72.8%) levels and HOMA (82.3%) value were higher, and QUI-KCI (13.2%) was lower in PCOS women when compared with controls. No significant association between PCOS and the variant allele of E-selectin Ser128Arg (OR: 1.17, 95% CI= 0.75-1.82) was observed. This polymorphism was found not to affect insulin resistance (IR) indices and lipid profile parameters significantly. Conclusion: These preliminary results suggest that the E-selectin Ser128Arg polymorphism is not a significant risk factor for PCOS alone. However, further studies on the same topic are necessary to support our observation before any statement can be made about the relationship between PCOS and E-selectin polymorphism. Key Words: E-selectin, insulin resistance, polycystic ovary syndrome, polymorphism. Conflict of Interest:The authors declare no conflict of interest. ÖZETAmaç: Polikistik over sendromun (PCOS) patojenezinde düşük derece kronik inflamasyon ve endotel disfonksiyonu önemli rol oynamaktadır. E-selektin, kronik inflamasyon durumlarında aktifleşen endotele lökositlerin tutunması ve transmigrasyonunu sağlayan bir hücre adezyon molekülüdür. E-selektin Ser128Arg polimorfizminin PCOS oluşumu ve PCOS'un klinik ve biyokimyasal özellikleri ilişkisi bu çalışma ile ilk kez incelenmektedir. Metod: 169 PCOS'lu ve 259 sağlıklı kadının periferik kan lökositlerinden elde edilen DNA ör-neklerinde E-selektin genin Ser128Arg polimorfizmi incelendi. Floresan etiketli hibridizasyon probları kullanarak "real-time PCR" yöntemiyle erime eğrileri analizi yapıldı. Bulgular: PCOS'lu hastalarının 85 (%50)'de insülin resistansı (IR) bulunmaktadır. Buna ilaveten, kontrollere kıyasla PCOS'lu kadınlarda insülin (%72.8) düzeyleri ve HOMA (%82.3) değerleri artmış, QUIKCI (%13.2) değerleri ise azalmış bulunmuştur. PCOS ile E-selektin Ser128Arg variant alleli arasında anlamlı bir ilişkiye rastlanmadı (OR: 1.17, 95% CI= 0.75-1.82). ...

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Lack of association between intercellular adhesion molecule-1 (ICAM-1) polymorphisms and polycystic ovary syndrome

Cited by 7 publications

References 32 publications

Histomorphometric Analysis and Markers of Endometrial Receptivity Embryonic Implantation in Women With Polycystic Ovary Syndrome During the Treatment With Progesterone

Histomorphometric Analysis and Markers of Endometrial Receptivity Embryonic Implantation in Women With Polycystic Ovary Syndrome During the Treatment With Progesterone

ICAM1K469E Polymorphism Effect in Gastroschisis Patients

The Ser128Arg polymorphism of E-selectin gene is not associated with polycystic ovary syndrome

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