Lack of Association Between Estrogen Receptor Genotypes and Bone Mineral Density, Fracture History, or Muscle Strength in Elderly Women

Vandevyver, Caroline; Vanhoof, Johan; Declerck, K.; Stinissen, Piet; Vandervorst, C.; Michiels, Luc; Cassiman, JJ; Boonen, Steven; Raus, Jef; Geusens, Piet

doi:10.1359/jbmr.1999.14.9.1576

Cited by 81 publications

(47 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Other studies in Korean (Han et al 1997), Belgian (Vandevyer et al 1999) and Italian (Gennari et al 1998) populations found no association between PvuII polymorphisms and bone mass. Whilst ESR PvuII alleles interacted with VDR alleles to predict BMD in the Italian study (Gennari et al 1998), no such effect was observed in the Belgian study (Vandevyer et al 1999). The molecular mechanism by which these polymorphisms influence bone mass are as yet unclear.…”

Section: Oestrogen Receptor (Esr)mentioning

confidence: 75%

Role of genetic factors in the pathogenesis of osteoporosis

Stewart¹,

Ralston²

2000

Journal of Endocrinology

192

125

View full text Add to dashboard Cite

Osteoporosis is a common disease with a strong genetic component characterised by low bone mass, microarchitectural deterioration of bone tissue and an increased risk of fracture. Twin and family studies have shown that genetic factors play an important role in regulating bone mineral density and other determinants of osteoporotic fracture risk, such as ultrasound properties of bone, skeletal geometry and bone turnover. Osteoporosis is a polygenic disorder, determined by the effects of several genes, each with relatively modest effects on bone mass and other determinants of fracture risk. It is only on rare occasions that osteoporosis occurs as the result of mutations in a single gene. Linkage studies in man and experimental animals have defined multiple loci which regulate bone mass but the genes responsible for these effects remain to be defined. Population-based studies and case-control studies have similarly identified polymorphisms in several candidate genes that have been associated with bone mass or osteoporotic fracture, including the vitamin D receptor, oestrogen receptor and collagen type I I gene. The individual contribution of these genes to the pathogenesis of osteoporosis is small however, reflected by the fact that the relationship between individual candidate genes and osteoporosis has been inconsistent in different studies. An important aim of future work will be to define how the genes which regulate bone mass, bone turnover and other aspects of bone metabolism interact with each other and with environmental variables to cause osteoporosis in individual patients. If that aim can be achieved then there is every prospect that preventative therapy could be targeted to those at greatest risk of the osteoporosis, before fractures have occurred.

show abstract

Section: Oestrogen Receptor (Esr)mentioning

confidence: 75%

Role of genetic factors in the pathogenesis of osteoporosis

Stewart¹,

Ralston²

2000

Journal of Endocrinology

192

125

View full text Add to dashboard Cite

show abstract

“…A polymorphism in the gene encoding a receptor for vitamin D has been associated with grip strength in postmenopausal women, but only in a nonobese subgroup [Geusens et al, 1997]. No association between a polymorphism in the estrogen receptor gene and strength was found in another study of postmenopausal women [Vandevyver et al, 1999].…”

Section: Discussionmentioning

confidence: 92%

Hand grip strength: A phenotype suitable for identifying genetic variants affecting mid‐ and late‐life physical functioning

Frederiksen

Garcı́a-Dorado

Petersen

et al. 2002

Genetic Epidemiology

182

137

View full text Add to dashboard Cite

Physical functioning late in life has been shown to be affected by genetic factors. Only a few genetic variants have been suggested to be associated with physical functioning, and this only in selected populations (e.g., young healthy males and elite athletes). Declining physical functioning late in life is a major problem in terms of prevalence, morbidity, functional limitations, and quality of life. It is therefore of interest to find a phenotype reflecting physical functioning which has a relatively high heritability and which can be measured in large samples. Hand grip strength is known to be associated with muscular functioning in other muscle groups and with activities of daily living (ADL) functioning, and it predicts incident disability. We studied 1,757 Danish twin pairs aged 45-96 years, and found that this phenotype has a heritability of 52% (95% confidence interval (CI), 48-55%). A powerful design to detect genes associated with a phenotype is obtained using the extreme discordant and concordant sib pairs, of whom 28 and 77 dizygotic twin pairs, respectively,

show abstract

“…Two studies found an association between VDR BsmI genotypes and muscle strength in postmenopausal women (Vandevyver et al 1999) and in healthy (non-obese) old women (Geusens et al 1997), with bb individuals exhibiting significantly higher quadriceps strength than those with the BB genotype, yet this association was not corroborated in obese old women (Geusens et al 1997). Hopkinson et al (2008) reported that the b allele of the BsmI polymorphism was associated with greater quadriceps strength in patients with chronic obstructive disease, but had no effect in healthy controls.…”

Section: Cross-sectional Genetic Association Studiesmentioning

confidence: 99%

Genes and the ageing muscle: a review on genetic association studies

Garatachea

Lucía

2011

AGE

View full text Add to dashboard Cite

Western populations are living longer. Ageing decline in muscle mass and strength (i.e. sarcopenia) is becoming a growing public health problem, as it contributes to the decreased capacity for independent living. It is thus important to determine those genetic factors that interact with ageing and thus modulate functional capacity and skeletal muscle phenotypes in older people. It would be also clinically relevant to identify 'unfavourable' genotypes associated with accelerated sarcopenia. In this review, we summarized published information on the potential associations between some genetic polymorphisms and muscle phenotypes in older people. A special emphasis was placed on those candidate polymorphisms that have been more extensively studied, i.e. angiotensinconverting enzyme (ACE) gene I/D, α-actinin-3 (ACTN3) R577X, and myostatin (MSTN) K153R, among others. Although previous heritability studies have indicated that there is an important genetic contribution to individual variability in muscle phenotypes among old people, published data on specific gene variants are controversial. The ACTN3 R577X polymorphism could influence muscle function in old women, yet there is controversy with regards to which allele (R or X) might play a 'favourable' role. Though more research is needed, up-to-date MSTN genotype is possibly the strongest candidate to explain variance among muscle phenotypes in the elderly. Future studies should take into account the association between muscle phenotypes in this population and complex gene-gene and gene-environment interactions.

show abstract

Lack of Association Between Estrogen Receptor Genotypes and Bone Mineral Density, Fracture History, or Muscle Strength in Elderly Women

Cited by 81 publications

References 33 publications

Role of genetic factors in the pathogenesis of osteoporosis

Role of genetic factors in the pathogenesis of osteoporosis

Hand grip strength: A phenotype suitable for identifying genetic variants affecting mid‐ and late‐life physical functioning

Genes and the ageing muscle: a review on genetic association studies

Contact Info

Product

Resources

About