Lack of association between dopamine-β hydroxylase gene and a history of suicide attempt in schizophrenia

Howe, Aaron; Leung, Tiffany; Bani‐Fatemi, Ali; Souza, Renan P.; Tampakeras, Maria; Zai, Clement C.; Kennedy, James L.; Strauss, John S.; Luca, Vincenzo De

doi:10.1097/ypg.0000000000000031

Cited by 3 publications

(5 citation statements)

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“…Our finding showed that DβH 5′‐Ins/Del polymorphism might not directly contribute to suicide attempts in patients with chronic schizophrenia. This finding was consistent with a study reporting that this polymorphism did not play a role in suicide attempts with chronic schizophrenia in the European population (Howe et al, 2014). Another study has reported that DβH rs2519152 polymorphism was not related to suicide attempts in subjects with psychiatric disorders (Murphy et al, 2011).…”

Section: Discussionsupporting

confidence: 93%

“…Any one of these DβH polymorphisms, such as rs1611115, rs1108580, rs2519152, and rs129882 was not significantly associated with suicidal behavior in alcohol‐dependent patients (Nedic Erjavec et al, 2014; Preuss et al, 2013). However, the DβH haplotype including DβH 5′‐del allele was reported to influence suicide attempts in chronic schizophrenia (Howe et al, 2014). Also, a study supported a significant relationship between DβH haplotype (including rs1611115, rs1108580, rs2519152, and rs129882) and suicidal behavior in alcohol‐dependent patients (Preuss et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have indicated that this polymorphism is associated with cognitive abnormality in older women, average reaction response time in Chinese females, attention bias for negative faces in young subjects, and post‐error slowing in the young Caucasian healthy adults that are correlated with suicidal behavior (Colzato, de Rove, van den Wildenberg, & Nieuwenhuis, 2013; Gong et al, 2011, 2013; Togsverd et al, 2007). DβH haplotype (consisting of DβH 5′‐del allele and 11 allele of GT n repeats) is linked to suicide attempts in schizophrenia (Howe, et al, 2014). Interestingly, DβH 5′‐Ins/Del polymorphism is implicated in attention in patients with chronic schizophrenia (Hui et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

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Association between dopamine beta‐hydroxylase polymorphism and attention function in suicide attempters with chronic schizophrenia

Hu²,

Zhu

et al. 2020

Human Psychopharmacology

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Background Patients with schizophrenia are at a higher risk for suicide compared with the general population. Dopamine beta‐hydroxylase (DβH) plays a key role in the conversion of dopamine to norepinephrine, which is related to suicidal behavior and cognitive regulation. Objective To examine whether there is the effect of DβH 5′‐insertion/deletion (Ins/Del) polymorphism on cognitive performance in suicide attempters with chronic schizophrenia. Methods This polymorphism was detected in 114 suicide attempters and 617 non‐suicide attempters with chronic schizophrenia. Cognitive performance was assessed by the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Results The allelic and genotypic frequencies of this polymorphism between two groups did not differ after controlling for covariates (both, p > .05). There were no differences in RBANS scores between two groups after adjusting for covariates (all, p > .05). However, based on the genotype grouping in suicide attempters and non‐attempters, the attention score significantly differed after adjusting for covariates (both, p < .05). Further analysis indicated that this polymorphism was associated with attention score in suicide attempters (p < .05), but not in non‐suicide attempters (p > .05). Conclusions DβH 5′‐Ins/Del polymorphism was not a risk locus of suicide attempters, but it was implicated in attention regulation in suicide attempters with chronic schizophrenia.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between dopamine beta‐hydroxylase polymorphism and attention function in suicide attempters with chronic schizophrenia

Hu²,

Zhu

et al. 2020

Human Psychopharmacology

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“…In this meta-analysis, the lifetime prevalence of SA in BD (33.9%; 95% CI 31.3–36.6%) was significantly higher than in the general population (0.8%; 95% CI 0.7–0.9%) (Bernal et al ., 2007; Cao et al ., 2015) and in schizophrenia (14.6%; 95% CI 9.1–22.8%), but was only slightly higher than the figures found in major depression (31%; 95% CI 27–34%) (Howe et al ., 2014; Dong et al ., 2017, 2018). The higher risk of SA in BD compared to major depression relates to the differences in clinical profile between both disorders (Szadoczky et al ., 2000).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of suicide attempts in bipolar disorder: a systematic review and meta-analysis of observational studies

Dong

Zhang

et al. 2019

Epidemiol Psychiatr Sci

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Original Article *These authors contributed equally to the work.Cite this article: Dong M et al (2020). Prevalence of suicide attempts in bipolar disorder: a systematic review and meta-analysis of observational studies. Epidemiology and Psychiatric Sciences 29, e63, 1-9. https://doi. AbstractAims. Bipolar disorder (BD) is a severe psychiatric disorder associated with a high risk of suicide. This meta-analysis examined the prevalence of suicide attempts (SA) in patients with BD and its associated factors. Methods. A systematic literature search was conducted in the PubMed, PsycINFO, EMBASE and Web of Science databases from their inception to 11 June 2018. The prevalence of SA in BD was synthesised using the random-effects model. Results. The search identified 3451 articles of which 79 studies with 33 719 subjects met the study entry criteria. The lifetime prevalence of SA was 33.9% (95% CI 31.3-36.6%; I 2 = 96.4%). Subgroup and meta-regression analyses revealed that the lifetime prevalence of SA was positively associated with female gender, BD-I, BD Not Otherwise Specified and rapid cycling BD subtypes, income level and geographic region. Conclusion. This meta-analysis confirmed that SA is common in BD and identified a number of factors related to SA. Further efforts are necessary to facilitate the identification and prevention of SA in BD. Long-term use of mood stabilisers coupled with psycho-social interventions should be available to BD patients to reduce the risk of suicidal behaviour.

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“…Increasing evidence indicates that the polymorphism in the 5′ untranslated region of DRD1 is associated with the mediation of the therapeutic response to antipsychotics,11 Moreover, present studies12–14 show that deficits in the DRD1 transmission are associated with the cognitive and negative symptoms of schizophrenia and that there is a significant decrease in DRD1 expression in the basal ganglia of schizophrenic patients 15. In contrast, some studies have reported that there was no genetic association between the DRD1 gene and the risk of schizophrenia 16–18. Therefore, the role of the DRD1 gene in schizophrenia remains controversial, and a consistent conclusion has yet to be achieved.…”

Section: Introductionmentioning

confidence: 69%

Association of dopamine D1 receptor gene polymorphism with schizophrenia: a meta-analysis

Pan¹,

Yao²,

Wang³

2014

NDT

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To date, the role of dopamine D1 receptor (DRD1) polymorphism in schizophrenia remains controversial. We carried out a meta-analysis to determine whether DRD1 polymorphism influences the risk of schizophrenia. We examined whether rs4532 and rs5326 genetic variants are related to the etiology of schizophrenia, using a meta-analysis. Relevant case-control studies were retrieved by database searching and selected according to established inclusion criteria. A total of ten studies were identified and included in our meta-analysis, nine for rs4532, with 1,941 cases and 2,480 controls, and four for rs5326, with 1,285 cases and 1,195 controls. No significant association was found between the rs4532 locus and schizophrenia. For the rs5326 locus, the guanine-adenine (GA) genotype was associated with schizophrenia as a risk factor (for GA vs guanine-guanine [GG], odds ratio [OR] =1.36, 95% confidence interval [CI]: 1.15–1.61, P<0.001). The GA genotype of rs5326 increased the risk of schizophrenia, but there was no association between rs4532 and schizophrenia. These data may provide references for case-control studies in schizophrenia in future.

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Lack of association between dopamine-β hydroxylase gene and a history of suicide attempt in schizophrenia

Cited by 3 publications

References 15 publications

Association between dopamine beta‐hydroxylase polymorphism and attention function in suicide attempters with chronic schizophrenia

Association between dopamine beta‐hydroxylase polymorphism and attention function in suicide attempters with chronic schizophrenia

Prevalence of suicide attempts in bipolar disorder: a systematic review and meta-analysis of observational studies

Association of dopamine D1 receptor gene polymorphism with schizophrenia: a meta-analysis

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