Lack of association between comorbidities and central centrifugal cicatricial alopecia: A retrospective cohort study of 153 patients

Jafari, Alexander J.; Brown, C.S. Vesey; Echuri, Harika; Murina, Andrea

doi:10.1016/j.jaad.2022.09.056

Cited by 4 publications

(6 citation statements)

References 4 publications

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“…In most of the previous studies, only a single session was used. 3 In only a few studies, more than one session was used. 3,4 Authors have mentioned that needling was done every 2 weeks for a maximum of three sessions.…”

Section: Tejas P Joshimentioning

confidence: 99%

“…3 In only a few studies, more than one session was used. 3,4 Authors have mentioned that needling was done every 2 weeks for a maximum of three sessions. Could authors specify if, after the first session, needling was performed on previously needled or new lesions?…”

Section: Tejas P Joshimentioning

confidence: 99%

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mentioning

confidence: 99%

“…1 The burden of comorbid disease in CCCA patients represents a knowledge gap for dermatologists, with current literature being limited to small studies often presenting contradictory findings. 2,3 Here, we investigate comorbidities associated with CCCA using the National Institute of Health's All of Us research program, a recently launched database that aims to collect health data on over 1 million Americans, with an emphasis on recruiting diverse communities historically underrepresented in research. 4 We designed a nested-case-control study in All of Us.…”

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confidence: 99%

“…Comments from the top 10 "diagnosis" and "follow-up" categories were assessed for quality in accordance with AAD acne guidelines and the comment net "upvotes" was tabulated. 3 This AAD-based grading system is defined in the footnotes of Table 2. Continuous variables were compared with an unpaired t test with P < 0.05 denoting statistical significance.…”

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confidence: 99%

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Comorbidities in patients with central centrifugal cicatricial alopecia: a case–control study

Joshi,

Duruewuru,

Garcia

et al. 2023

Int J Dermatology

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we did not prefer infliximab. 3 A case of FSGS without Ig deposition whose psoriasis and nephropathy regressed with secukinumab was reported in the literature. 7 The other reported case developed IgAN in the 5th month of secukinumab treatment, and proteinuria improved after tonsillectomy and pulse steroid therapy without discontinuation of treatment. The authors attributed the nephropathy to obesity and metabolic syndrome developed due to lifestyle changes of the patient, not due to secukinumab because proteinuria regressed despite continued treatment. 8 IL17, one of the key cytokines in psoriasis pathogenesis, increases the release of proinflammatory cytokines in patients with IgAN, increases IgA1 production by stimulating B lymphocytes, leads to underglycosylation of IgA1. Additionally, higher IL17A levels were detected in the urine and serum of IgAN patients. Therefore, IL-17 blocking can be an effective agent in the treatment of IgAN. 7,8 The effectiveness and safety of secukinumab in psoriasis with IgAN require confirmation by long-term follow-up studies of more patients. Our successful treatment of a patient provides a reference for the future treatment of such patients.

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Section: Tejas P Joshimentioning

confidence: 99%

Section: Tejas P Joshimentioning

confidence: 99%

“…

…”

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Comorbidities in patients with central centrifugal cicatricial alopecia: a case–control study

Joshi,

Duruewuru,

Garcia

et al. 2023

Int J Dermatology

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Risk factors and comorbidities associated with central centrifugal cicatricial alopecia

Green,

Feschuk,

Valdebran

2023

International Journal of Women’s Dermatology

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Central centrifugal cicatricial alopecia (CCCA) is the most common form of scarring alopecia that most often affects Black women. The disease typically begins with hair loss in the center scalp, which progresses in a centripetal fashion. Both environmental insult and genetics have been implicated in CCCA etiology, although the exact pathophysiology remains unknown. Nevertheless, it is important that providers feel comfortable educating their patients on risk factors (RFs) for the development or worsening of CCCA, and potential comorbidities associated with the condition. Thus, the goal of this review was to summarize these factors. A comprehensive literature search was performed, and studies were included if they reported research on RFs for or comorbidities associated with, CCCA. A total of 15 studies were included: n = 5 researching RFs for CCCA and n = 10 researching comorbidities associated with CCCA. There was an association suggesting an increased risk of CCCA with traction hairstyles in n = 2/3 studies, previous pregnancies in n = 1/1 studies, and use of chemical hair relaxers in n = 1/3 studies. Additionally, age and total years of hair loss were associated with increased CCCA severity in n = 2/2 studies. Type 2 diabetes was positively associated with CCCA in n = 3/5 studies, uterine leiomyomas in n = 1/2 studies, hyperlipidemia in n = 1/2 studies, and vitamin D deficiency in n = 1/1 studies. Conflicting results regarding RFs and comorbidities associated with CCCA exist within the literature. Thus, further investigation in larger cohorts must be done, and future research into genes implicated in CCCA and their potential role in the development of other diseases is recommended.

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Updates on disorders in curly hair

Geisler,

Taye,

Larrondo

et al. 2024

Int J Dermatology

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Hair disorders, including central centrifugal cicatricial alopecia (CCCA), traction alopecia (TA), and acquired trichorrhexis nodosa (ATN), commonly occur in individuals with curly textured hair. Curly textured hair in individuals of African descent has unique properties and can present diagnostic and therapeutic challenges. CCCA has been linked to uterine leiomyoma and type 2 diabetes mellitus, as well as fibroproliferation. TA often presents with a fringe sign and can arise from high‐tension hairstyles presumed to be protective. Trichoscopy is useful in establishing a diagnosis; perifollicular halos are more commonly seen than perifollicular erythema or scale in CCCA. In TA, miniaturized follicles, hair casts, and “flambeau sign” can be seen. Hairstyling practices likely contribute to TA and ATN; however, the data are mixed on the role of chemical relaxers and heat styling in CCCA. Unique considerations in the presentation of frontal fibrosing alopecia in curly textured hair have also been published recently. This review provides a comprehensive, up‐to‐date summary of these disorders with an emphasis on their unique properties, as well as considerations in hair care for curly textured hair.

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Lack of association between comorbidities and central centrifugal cicatricial alopecia: A retrospective cohort study of 153 patients

Cited by 4 publications

References 4 publications

Comorbidities in patients with central centrifugal cicatricial alopecia: a case–control study

Comorbidities in patients with central centrifugal cicatricial alopecia: a case–control study

Risk factors and comorbidities associated with central centrifugal cicatricial alopecia

Updates on disorders in curly hair

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