Lack of association between celiac disease and dental enamel hypoplasia in a case-control study from an Italian central region

Procaccini, Maurizio; Campisi, Giuseppina; Bufo, Pantaleo; Compilato, Domenico; Massaccesi, Claudia; Catassi, Carlo; Muzio, Lorenzo Lo

doi:10.1186/1746-160x-3-25

Cited by 38 publications

(40 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CD also presents oral manifestations, which are dental enamel defects and recurrent aphthous stomatitis (RAS) [3,8,9,10,11,12,13,14,15,16,17,18,19]. The existence of an association between CD and dental enamel defects has been reported and the enamel defects have been attributed to hypocalcemia or a particular genetic condition that leads to a specific immune response to gluten [9].…”

Section: Introductionmentioning

confidence: 99%

Oral Findings and Salivary Parameters in Children with Celiac Disease: A Preliminary Study

et al. 2011

View full text Add to dashboard Cite

Objective: The aim of this study was to investigate the prevalence of dental enamel defects, recurrent aphthous stomatitis (RAS) and caries experience and to measure salivary flow rate, buffer capacity, saliva and plaque pH and salivary cariogenic microflora in patients with celiac disease (CD) compared to healthy subjects. Subjects and Methods: Thirty-five patients, aged 6-19 years, with a diagnosis of CD and 35 healthy children of the same age participated in the study. Enamel defects were diagnosed and classified using Aine's classification. The patients with RAS and dental caries were recorded using WHO criteria. The parents were interviewed about various oral health-related factors. Saliva samples were collected to measure the stimulated salivary flow rate, buffer capacity and pH values of saliva and plaque. Salivary mutans streptococci and lactobacilli were counted. Results: The enamel defects and RAS prevalence were statistically higher (40 and 37.1%, respectively) in the CD group, and the prevalence of salivary mutans streptococci (48 and 14%) and lactobacilli (51 and 34%) colonization was statistically lower (p = 0.012, p = 0.010) in the CD group; the DMFS and dfs values were similar in both groups. Conclusion: CD appeared to be associated with a significantly higher prevalence of developing enamel defects and RAS, but a lower prevalence of salivary mutans streptococci and lactobacilli colonization, and the diagnosis of these oral manifestations might be helpful for an early diagnosis of CD.

show abstract

Section: Introductionmentioning

confidence: 99%

Oral Findings and Salivary Parameters in Children with Celiac Disease: A Preliminary Study

et al. 2011

View full text Add to dashboard Cite

show abstract

“…CD can cause vitamin (D and K) and micronutrient (calcium, iron, folate) deficiencies, with prolonged cases often leading to conditions such as rickets, osteoporosis, and anemia (Farrell and Kelly 2002;Fasano 2005;Green and Cellier 2007). Linear enamel hypoplasias on the teeth, a marker of nutritional stress, have been noted in greater than twenty percent of CD cases in children (Bucci et al 2007;Campisi et al 2007;Cheng et al 2010, but see Procaccini et al 2007, for a contrasting result). Neurological abnormalities including hypotonia, developmental delay, learning disorders and ADHD, headache, and cerebellar ataxia have also been reported to be more common in children with CD (Zelnik et al 2004).…”

Section: Presentation Pathophysiology and Genetics Of CDmentioning

confidence: 99%

Celiac Disease as a Model for the Evolution of Multifactorial Disease in Humans

Sams

Hawks

2014

Human Biology

View full text Add to dashboard Cite

Abstract. Celiac disease (CD) is a multifactorial chronic inflammatory conditionthat results in injury of the mucosal lining of the small intestine upon ingestion of wheat gluten and related proteins from barley and rye. Although the exact mechanisms leading to CD are not fully understood, the genetic basis of CD has been relatively well characterized. In this review we briefly review the history of discovery, clinical presentation, pathophysiology, and current understanding of the genetics underlying CD risk. Then, we discuss what is known about the current distribution and evolutionary history of genes underlying CD risk in light of other evolutionary models of disease. Specifically, we conclude that the set of loci underlying CD risk did not cohesively evolve as a response to a single past selection event such as the development of agriculture. Rather, deterministic and stochastic evolutionary processes have both contributed to the present distribution of variation in CD risk loci. Selection has shaped some components of this network, but this selection appears to have occurred at different points in the past.Other parts of the CD risk network have likely arisen due to stochastic processes such as genetic drift. Celiac disease (CD) is a multifactorial chronic inflammatory condition that resultsin injury of the mucosal lining of the small intestine. The earliest descriptions of a condition with symptoms like CD date back to the first and second century writings of the Greek physician Arataeus (Simoons 1981;Losowsky 2008). The first modern description of CD is attributed to English physician Samuel Jones Gee, who was familiar with the writings of Arataeus. In 1888 (Dowd and Walker-Smith 1974;Simoons 1981;Losowsky 2008) Gee described the 'coeliac affection' as a condition of chronic indigestion associated with diarrhea, wasting, and weakness and common in people of all ages. Gee's report was the first to hypothesize dietary factors as a primary cause of the condition (Dowd and Walker-Smith 1974), and during the early twentieth century some workers noted the value of a starch free diet for prevention of CD (Haas 1924). Dicke and colleagues (1950, 1953) observed the detrimental effect of wheat flour (but not wheat starch) on CD patients experimentally confirming a role for diet as a driver of CD. Shortly thereafter, Anderson and colleagues (Anderson et al. 1952;Alvey et al. 1957) confirmed the effect of wheat on CD and identified wheat gluten as the primary culprit.CD appears to be an evolutionary paradox. Only since the 1950s have clinicians recognized that a gluten-free diet is an effective treatment (Barker and Liu 2008). Before that time, diagnosed and undiagnosed CD reduced the health and fitness of sufferers, with juvenile cases leading to malnutrition or death, and adult cases causing wasting, lack of adequate nutrition, greater susceptibility to infection, and direct reductions in fertility (Corrao et al. 2001;Soni and Badawy 2010). Despite these apparent costs, CD is common today (>1%) in several popul...

show abstract

“…Interessante destacar que os autores desses trabalhos atribuíram a ausência de diferenças significantes, em parte, à alta ocorrência de defeitos de esmalte encontrados nos grupos controle, que variaram entre 38 a 68% nas amostras (Andersson-Wenckert et al, 1984;Rasmusson e Eriksson, 2001;Procaccini et al, 2007).…”

Section: Discussionunclassified

“…Especula-se que haja essa associação devido ao caráter autoimune presente nas duas patologias (Acar et al, 2011). Sugere-se, portanto, que a ocorrência de lesões aftoides idiopáticas, principalmente em indivíduos com defeitos de formação no esmalte dental, seja um critério relevante para a investigação da doença celíaca (Sedghizadeh et al, 2002;Procaccini et al, 2007;Pastore et al, 2008;Cheng et al, 2010;Acar et al, 2011).…”

Section: Discussionunclassified

“…A prevalência de defeitos de esmalte específicos varia de 38 a 96% em crianças com doença celíaca e de 0,6 a 17% em indivíduos que não apresentam a doença (Aine et al, 1992;Martelossi et al, 1996;Aguirre et al, 1997;Patinen et al, 2004;Priovolou et al, 2004;Acar et al, 2011). Entretanto, a associação entre defeitos de esmalte e doença celíaca ainda é controversa, pois estudos conduzidos na Suécia (Andersson-Wenckert et al, 1984;Rasmusson e Eriksson, 2001) e na Itália (Procaccini et al, 2007) não relataram tal associação.…”

Section: Introductionunclassified

See 1 more Smart Citation

Doença celíaca: repercussões bucais e estudo do esmalte dental como marcador da doença

Carvalho¹

View full text Add to dashboard Cite

Lack of association between celiac disease and dental enamel hypoplasia in a case-control study from an Italian central region

Cited by 38 publications

References 47 publications

Oral Findings and Salivary Parameters in Children with Celiac Disease: A Preliminary Study

Oral Findings and Salivary Parameters in Children with Celiac Disease: A Preliminary Study

Celiac Disease as a Model for the Evolution of Multifactorial Disease in Humans

Doença celíaca: repercussões bucais e estudo do esmalte dental como marcador da doença

Contact Info

Product

Resources

About