Lack of Association between BSG Polymorphisms and Cerebral Malaria

Naka, Izumi; Patarapotikul, Jintana; Hananantachai, Hathairad; Ohashi, Jun

doi:10.7883/yoken.67.432

Cited by 4 publications

(4 citation statements)

References 16 publications

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“…Unexpectedly, we did not find any SNP that is directly related to the differential BSG expression, although Tham and coworkers reported that a specific SNP is responsible for the high or low CR1 expression. Another study showed that no BSG gene SNP correlated with susceptibility to malaria was observed . Likewise, this study did not observe any direct correlation between BSG gene polymorphism and OK/BSG level.…”

Section: Discussioncontrasting

confidence: 74%

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OK/basigin expression on red blood cells varies between blood donors and correlates with binding of recombinant Plasmodium falciparum reticulocyte‐binding protein homolog 5

Zhao

Yang

et al. 2018

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Section: Discussioncontrasting

confidence: 74%

“…Another study showed that no BSG gene SNP correlated with susceptibility to malaria was observed. 17 Likewise, this study did not observe any direct correlation between BSG gene polymorphism and OK/BSG level. Nevertheless, this study found that posttranscriptional regulation might be involved in the BSG expression on RBCs.…”

Section: Discussioncontrasting

confidence: 59%

OK/basigin expression on red blood cells varies between blood donors and correlates with binding of recombinant Plasmodium falciparum reticulocyte‐binding protein homolog 5

Zhao

Yang

et al. 2018

Transfusion

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“…(13) . The Ok(a) blood group antigen basigin (BSG or CD147) is an erythrocyte receptor for the PfRh5 protein from Plasmodium falciparum and the PfRh5-BSG interaction is essential for erythrocyte invasion by Pf (14) . Anopheles stephensi mosquito, which is the main malaria vector in Iran, southwest Asia, and India, were fed either artificially on A/B/O/AB membrane blood feeders or directly on human volunteer hands and forearms of A/B/O/AB groups, under lab conditions.…”

Section: Discussionmentioning

confidence: 99%

Relationship between Malaria and ABO Blood Group Types

2015

IJSR

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Abstract:Introduction: There is a paucity of studies on the relationship between ABO blood group and its influence on malarial infection. This study was undertaken to study the relationship of severity of malaria with blood groups and to evaluate if ABO blood groups show differential susceptibility to falciparummalaria. Methods: In 200 malaria positive patients, blood group analysis was done. Patients with at least one of the following complications was considered complicated malaria cases, ie: cerebral malaria, severe anemia, circulatory collapse, jaundice, hematuria, bleeding manifestations, acute respiratory distress syndrome, and death. Results: Vivax malaria (75.5%) and blood group O (43%) were the commonest amongst the cases. No significant relationship was present between blood groups and type of infection, parasite load vs blood groups, and complicated cases vs parasite load. Uncomplicated (62%) cases were more than complicated (31%) cases. Blood group O dominated among complicated (37.9%) and uncomplicated (45.65%) cases. No signifiant correlation was present between blood groups and distribution of complicated cases, and between complicated falciparum cases and blood groups. Seven cases of mixed malaria had blood group A and O. Among A blood group, 57.1% of the mixed malaria cases had complications, whereas in O blood group only 14.3% had complications. There was a statistically significant relation between complicated mixed malaria cases and blood groups, with blood group A being more prone to complications. (X 2 =15.131; P=0.019). Conclusions: Blood group O was the dominant blood type in both complicated and uncomplicated malaria cases. Blood group A cases were more prone to severe mixed malaria infections while, blood group O had a favorable clinical outcome.

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“…BSG rs11473 polymorphism within miR-483-5p binding site was reported to be associated with increased risk of esophageal cancer in a Chinese population [29]. Other studies failed to demonstrate an association between BSG polymorphisms and risk of schizophrenia [30], cerebral malaria [31], and atherosclerotic cerebral infarction [32]. …”

Section: Discussionmentioning

confidence: 99%

Basigin rs8259 Polymorphism Confers Decreased Risk of Chronic Heart Failure in a Chinese Population

et al. 2017

IJERPH

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Left ventricular remodeling is an essential risk factor contributing to the pathogenesis of chronic heart failure (CHF). Basigin (BSG) promotes cardiovascular inflammation and myocardial remodeling processes by induction of extracellular matrix metalloproteinases and inflammatory cytokines. BSG rs8259 polymorphism was associated with BSG expression and risk of acute coronary syndrome. Therefore, we investigated whether rs8259 polymorphism contributes to risk and prognosis of CHF in Chinese patients. In total 922 adult patients with CHF and 1107 matched healthy controls were enrolled. BSG rs8259 polymorphism was genotyped using PCR-restriction fragment length polymorphism. Whole blood BSG mRNA expression data from Genotype-Tissue Expression project was accessed. Evaluation of follow-up data was performed in only 15.2% (140) of the patients with CHF. BSG rs8259 TT genotype was associated with a decreased risk of CHF (OR = 0.83, 95% CI = 0.72–0.96, p = 0.010), especially in patients with hypertension (OR = 0.80, 95% CI = 0.68–0.95, p = 0.011) and coronary heart disease (OR = 0.81, 95% CI = 0.69–0.96, p = 0.013) after adjustment for multiple cardiovascular risk factors. Rs8259 T allele was associated with decreased BSG mRNA in whole blood from 338 healthy normal donors (p = 1.31 × 10−6). However, rs8259 polymorphism failed to exhibit an association with cardiovascular mortality (p = 0.283). BSG rs8259 polymorphism may contribute to decreased risk of CHF in a Chinese Han population.

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Lack of Association between BSG Polymorphisms and Cerebral Malaria

Cited by 4 publications

References 16 publications

OK/basigin expression on red blood cells varies between blood donors and correlates with binding of recombinant Plasmodium falciparum reticulocyte‐binding protein homolog 5

OK/basigin expression on red blood cells varies between blood donors and correlates with binding of recombinant Plasmodium falciparum reticulocyte‐binding protein homolog 5

Relationship between Malaria and ABO Blood Group Types

Basigin rs8259 Polymorphism Confers Decreased Risk of Chronic Heart Failure in a Chinese Population

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