Lack of association between Alzheimer's disease and histocompatibility antigens

Abstract

The present report describes the distribution of histocompatibility antigens in 52 patients with Alzheimer's disease. No significant associations were observed between this illness and particular HLA types before or after statistical correction for multiple comparisons. These findings are discussed in terms of the difficulties inherent in the clinical diagnosis of Alzheimer's disease and with regard to the choice of suitable control populations.

Nicotine reverses adult‐onset hypothyroidism‐induced impairment of learning and memory: Behavioral and electrophysiological studies

“…Furthermore, hippocampi of aged animals show lower levels of thyroid hormone receptor mRNA (Enderlin et al,1997) and RC3 mRNA and protein levels (Mons et al,2001) compared with those of young adult rats. Hypothyroidism is also listed as a likely risk factor for Alzheimer's disease (Reisner et al,1983), for which it has been shown that the mRNA levels of thyroid hormone receptor are reduced in the hippocampus of Alzheimer's patients (Sutherland et al,1992).…”