Lack of acute zinc effect on thyrotropin-releasing hormone–stimulated thyroid-stimulating hormone secretion during oral zinc tolerance test in healthy men

Brandão-Neto, José; Saturnino, Ana Conceição Ribeiro Dantas; Leite, Lúcia Dantas; Rocha, Érika Dantas de Medeiros; Marcos, C; Silva, Carlos Antônio Bruno da; Marchini, Júlio Sérgio; Rezende, Adriana Augusto de; Almeida, Maria das Graças; Medeiros, Aldo da Cunha

doi:10.1016/j.nutres.2006.08.010

Cited by 21 publications

(8 citation statements)

References 18 publications

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“…Zinc is an indispensable element in the functioning of 1,5′-deiodinase, which is necessary for the conversion of T 4 to T 3 [6]. Besides being required for the activity of thyroid hormones, zinc is essential for the synthesis of TSH from hypophysis and TRH from hypothalamus [7,21]. When the available information about the relation between zinc and thyroid is considered, changes in thyroid activity can be expected to result in variations in zinc levels.…”

Section: Discussionmentioning

confidence: 99%

“…Zinc is an indispensable element in the functioning of 1,5′-deiodinase, which is required for the conversion of T 4 to T 3 , its active form, [6]. Zinc is necessary not only for the functioning of thyroid hormones, but also for the synthesis of TSH from hypophysis and TRH from hypothalamus [1,7]. In their study, Wada and King [8] examined for the first time the relationship between zinc values and thyroid hormone values and discovered the effect of zinc supplementation on thyroid hormone functions.…”

Section: Introductionmentioning

confidence: 99%

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Changes in the Serum Levels of Trace Elements Before and After the Operation in Thyroid Cancer Patients

Baltacı

Dundar

Aksoy

et al. 2016

Biol Trace Elem Res

105

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The present study aims to examine the changes in the serum levels of trace elements before and after the operation in thyroid cancer patients. The study registered 50 individuals, of whom 25 were female and 25 were male. The patients were allocated to four groups: group 1: male thyroid cancer patients group (n = 15), group 2: female thyroid cancer patients group (n = 15), group 3: male control group (n = 10), group 4: female control group (n = 10). The subjects in groups 1 and 2 were the patients who were post-operatively diagnosed with a pathological malignancy in the thyroid tissue samples. Blood samples were collected from all subjects before the operation, immediately after the operation, and on the post-operative day 15. Additionally, thyroid tissue samples were taken from all subjects post-operatively. Some elements in the blood and tissue samples were determined using the atomic emission method. Zinc and selenium levels of groups 1 and 2 in the pre- and post-operative measurements were significantly lower than those in the control groups (p < 0.05), but were higher in the thyroid tissue (p < 0.05). Serum zinc and selenium levels measured in the subjects on the post-operative day 15 were similar to those measured in the controls. Our study show that changes in the serum and thyroid tissue levels of trace elements like zinc and selenium, which play a critical role in thyroid function, might be associated with the pathogenesis of thyroid cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Changes in the Serum Levels of Trace Elements Before and After the Operation in Thyroid Cancer Patients

Baltacı

Dundar

Aksoy

et al. 2016

Biol Trace Elem Res

105

View full text Add to dashboard Cite

show abstract

“…Zinc is an indispensable element in the functioning of 1,5-deiodinase, which is an enzyme catalyzing the conversion of T 4 into its active form T 3 (14) . Zinc is required not only for the activity of thyroid hormones but also for the synthesis of TSH in the anterior hypophysis and that of TRH in the hypothalamus (15,16). When evaluating the current information on the relation between zinc and thyroid as a whole, any change in thyroid activity can be expected to be resulting in a change in zinc levels.…”

Section: Discussionmentioning

confidence: 99%

L-thyroxine-induced hyperthyroidism affects elements and zinc in rats

Baltacı

Moğulkoç²,

Belviranlı³

2013

BLL

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There is a signifi cant relation between thyroid hormones and zinc. The establishment of low blood zinc levels in hypothyroidism as opposed to high blood zinc levels in hyperthyroidism testifi es to this relation. The present study aims to examine the changes in levels of some elements in sera of rats with induced hyperthyroidism as well as the relation between these changes and zinc. Thirty adult male rats of Sprague-Dawley type were equally allocated to three groups, particularly Group 1: General Control, Group 2: Sham-hyperthyroidism Group, and Group 3: Hyperthyroidism Group. Subsequent to decapitating the animals, their blood samples were taken and analyzed with the help of atomic emission spectrophotometer in terms of serum levels of zinc, selenium, calcium, magnesium, phosphorus, chromium, copper and iron. The levels of zinc, selenium and calcium were higher (p < 0.01), while those of chromium, copper, iron and phosphorus were lower (p < 0.01) in Group 3, relative to groups 1 and 2. These parameters were not different in groups 1 and 2. The results obtained from the study indicate that hyperthyroidism brings about some changes in the levels of some elements in rats. These changes might be associated with the elevation of zinc levels in hyperthyroidism (Tab. 2, Ref. 41).

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“…Ertek et al stated a positive correlation between serum zinc concentrations and free T 3 in euthyroid participants, and also found a positive correlation between TSH and serum zinc levels in women with normal thyroid function, nodular goiter and autoimmune thyroid (Ertek et al 2013). In contrast, Brandão-Neto et al (2006) reported that single-dose oral zinc intake in healthy men did not affect TSH concentrations (Brandão-Neto et al 2006). A study from Iran included 110 thyroid patients and found a significant decrease in zinc levels of hypothyroid patients compared to healthy individuals.…”

Section: Zinc and Thyroid Metabolismmentioning

confidence: 99%

Halk Sağlığı Açısından Sigara Bağımlılığı ve Mücadele Yöntemleri: Küresel Düzeyde Karşılaştırmalı Bir Analiz

Çeçen¹,

Güvenç²

2023

Sağlık Bilimleri Araştırmaları: Temel Tıp

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21. yy’da dünyadaki ülkelerin toplumları üzerinde çeşitli hastalıklar ortaya çıkmıştır. Ortaya çıkan bu hastalıklar içerisinde en büyük paylardan biri de kötü alışkanlıkların getirdiği hastalıklar olarak karşımıza çıkmaktadır. İnsanların tütün ve tütün ürünlerine olan bağımlılıkları da bu alışkanlıklar arasında yer almaktadır. Tütün ve tütün ürünleri içerisinde toplumlarda en çok kullanılan ve ilk akla gelen sigaradır. Sigaranın insanlar üzerindeki olumsuz etkileri, sebep olduğu hastalıklar uzmanlar tarafından desteklenmektedir. Ancak tüm bunlara rağmen sigara bağımlılığı oranları istenilen seviyelere düşmemiştir. Bağımlılık seyrinin böyle devam etmesi de küresel bağlamda büyük bir sorun oluşturmuş ve devletlerin sağlık sistemleri üzerinde de büyük baskı oluşturmuştur. Sağlık alanındaki kıt kaynakların doğru şekilde kullanılması devletler adına çok önemlidir. Tütün ve tütün ürünlerine bağlı olarak gelişen ağır rahatsızlıklar ve ölümlerin önüne geçebilmek adına yerel ve ulusal bağlamda birtakım adımlar atılmıştır. Bu kapsamda Dünya Sağlık Örgütü, 2003 yılında “Tütün Kontrol Çerçeve Sözleşmesi“ni, 2008 yılında ise “MPOWER“ paket programını tasarlayarak bir adım atmıştır. Bu uygulamayla birlikte dünyadaki ülkelerin çoğunda tütün kontrolünde gözle görülür ilerlemeler olmuştur. Bu ilerlemenin sürdürülebilir olması için paketin uygulama alanları genişletilmelidir. Aksi takdirde tütün ve tütün ürünlerinin olumsuz etkilerinin önüne geçmek zorlaşacaktır.

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Lack of acute zinc effect on thyrotropin-releasing hormone–stimulated thyroid-stimulating hormone secretion during oral zinc tolerance test in healthy men

Cited by 21 publications

References 18 publications

Changes in the Serum Levels of Trace Elements Before and After the Operation in Thyroid Cancer Patients

Changes in the Serum Levels of Trace Elements Before and After the Operation in Thyroid Cancer Patients

L-thyroxine-induced hyperthyroidism affects elements and zinc in rats

Halk Sağlığı Açısından Sigara Bağımlılığı ve Mücadele Yöntemleri: Küresel Düzeyde Karşılaştırmalı Bir Analiz

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