Lack of a relation between serum 25-hydroxyvitamin D concentrations and asthma in adolescents

Gergen, Peter J.; Teach, Stephen J.; Mitchell, Herman; Freishtat, Robert J.; Calatroni, Augustin; Matsui, Elizabeth C.; Kattan, Meyer; Bloomberg, Gordon R.; Liu, Andrew H.; Kercsmar, Carolyn M.; O’Connor, George T.; Pongracic, Jacqueline A.; Rivera-Sanchez, Yadira; Morgan, Wayne J.; Sorkness, Christine A.; Binkley, Neil; Busse, William W.

doi:10.3945/ajcn.112.046961

Cited by 34 publications

(52 citation statements)

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“…In a study, the frequency of vitamin D deficiency (54%) or insufficiency (86%) in 92 African-American asthmatic children aged 6-20 years was found to be higher than in healthy controls (18). However, there are other studies that did not find a difference in Vitamin D levels between patients with and without asthma (8,(13)(14)(15). In accordance with these reports, serum vitamin D levels were similar in patients with and without asthma in our study.…”

Section: Discussionsupporting

confidence: 79%

“…Gergen et al reported the absence of a relationship between vitamin D levels and severity of asthma among adolescents (14). Serum vitamin D levels of the patients and control group in that report was under 20 ng/ml, as was the case in our study.…”

mentioning

confidence: 37%

“…claimed no relationship between asthma and vitamin D levels (8,14,15,18). As a matter of fact this was the case in our study as vitamin D deficiency was present in 97.5% and insufficiency was present in 2.5% of our study group and Vitamin D levels did not differ between patients with and without asthma.…”

mentioning

confidence: 42%

“…In birth cohorts, maternal vitamin D and cord blood level of vitamin D are reported to be inversely associated with asthma (12,13). However, in some studies evaluating adolescent patients, serum vitamin D levels were not found to be different between subjects with or without asthma (14,15).…”

Section: Introductionmentioning

confidence: 95%

See 3 more Smart Citations

Vitamin D Levels of Asthmatic Children with and Without Obesity

Erkoçoğlu

Çapanoğlu²,

Civelek³

et al. 2016

Asthma Allergy Immunol

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Section: Discussionsupporting

confidence: 79%

mentioning

confidence: 37%

mentioning

confidence: 42%

Section: Introductionmentioning

confidence: 95%

See 2 more Smart Citations

Vitamin D Levels of Asthmatic Children with and Without Obesity

Erkoçoğlu

Çapanoğlu²,

Civelek³

et al. 2016

Asthma Allergy Immunol

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“…Bazı kesitsel çalışmalarda serum D vitamini düzeylerinin astımlı çocuklarda sağlıklı çocuklara göre daha düşük olduğu (4,(10)(11)(12) sınırlı sayıdaki çalışmada serum D vitamini düzeylerindeki yüksekliğinin astım riskinde artmaya neden olduğu gösterilmiştir (13,14). Bazı çalışmalarda ise bu farklılıklar gözlenmemiştir (15)(16)(17)(18)(19). D vitamini ve günümüzdeki astım rehberlerinde astım tedavisinin ana amacı olarak ifade edilen astım kontrolü ilişkili yapılmış sınırlı sayıda çalışma vardır.…”

Section: Introductionunclassified

Effects of Vitamin D Levels on Asthma Control and Severity in Children

Türkeli¹,

Ayaz²,

Uncu³

et al. 2016

Asthma Allergy Immunol

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ÖZGiriş: Günümüzde astım ve vitamin D eksikliği prevalansı oranı paralel şekilde artmakta ve önemli morbiditelere neden olmaktadır. Çalışmanın amacı, serum D vitamini düzeylerini astımlı çocuklar ile sağlıklı kontroller arasında karşılaştırmak, D vitamini düzeylerinin astım klinik parametreleri ile ilişkisini ve astım kontrolü üzerine etkisini değerlendirmektir. Results: Serum vitamin D levels were 17.27 (5.77) ng/ml in the asthma group and 22.78 (10.64) ng/ml in the control group, indicating statistical significance (p= 0.001). When the asthma patients were divided into groups according to vitamin D level, 72.2% were deficient while 27.8% had adequate levels. The number of asthma exacerbations, number of emergency service visits and the number of hospitalizations within the last year were higher in the deficient group, compared to the adequate group (p <0.001, p Gereç ve

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Vitamin D and Asthma—Life After VIDA?

Brehm

2014

Curr Allergy Asthma Rep

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The vitamin D hypothesis postulates that lower vitamin D levels are causally associated with increased asthma risk and asthma severity. Multiple epidemiological studies have shown an inverse relationship between circulating vitamin D levels (in the form of 25-hydroxy-vitamin D) and asthma severity and control, and lung function. However, in the recently published VIDA study, vitamin D supplementation failed to show an improvement in asthma control in adults. This article reviews the current epidemiological and trial evidence for vitamin D and asthma, and explores some of the possible alternative explanations for previous findings (including “reverse causation” and the importance of studying children and adults). We also address some of the unique challenges of conducting vitamin D trials, and potential ways to address them. Finally, I will argue for further clinical trials of vitamin D in asthma, especially in children, using knowledge gained from the VIDA trial.

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Lack of a relation between serum 25-hydroxyvitamin D concentrations and asthma in adolescents

Abstract: In 2 samples of adolescents, overall serum 25(OH)D concentrations were low and were not consistently associated with the presence of asthma, multiple asthma characteristics, asthma morbidity, or response to treatment. The ACE trial was registered at clinicaltrials.gov as NCT0011441.

Cited by 34 publications

References 29 publications

Vitamin D Levels of Asthmatic Children with and Without Obesity

Vitamin D Levels of Asthmatic Children with and Without Obesity

Effects of Vitamin D Levels on Asthma Control and Severity in Children

Vitamin D and Asthma—Life After VIDA?

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