Lacaziose simulando hanseníase dimorfa tuberculóide

Tubilla, Liana Hortência Miranda; Schettini, Antônio Pedro Mendes; Eiras, Josie da Costa; Graça, Claudia Zanardo Alves da; Frota, Maria Zeli Moreira

doi:10.1590/s0365-05962008000300011

Cited by 5 publications

(2 citation statements)

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“…Currently, JLD diagnosis is based on a clinical evaluation of the patient. This evaluation consists of a macroscopic examination of lesions, which may be keloid-like, verruciform and/or gummy; there may also be ulcerative lesions [ 10 , 11 ]. The fungus can also be detected in skin lesions via histopathological and mycological examinations [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Immune Response Markers in Jorge Lobo's Disease Lesions Suggests the Occurrence of Mixed T Helper Responses with the Dominance of Regulatory T Cell Activity

et al. 2015

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Jorge Lobo’s disease (JLD) is a chronic infection that affects the skin and subcutaneous tissues. Its etiologic agent is the fungus Lacazia loboi. Lesions are classified as localized, multifocal, or disseminated, depending on their location. Early diagnosis and the surgical removal of lesions are the best therapeutic options currently available for JLD. The few studies that evaluate the immunological response of JLD patients show a predominance of Th2 response, as well as a high frequency of TGF-β and IL-10 positive cells in the lesions; however, the overall immunological status of the lesions in terms of their T cell phenotype has yet to be determined. Therefore, the objective of this study was to evaluate the pattern of Th1, Th2, Th17 and regulatory T cell (Treg) markers mRNA in JLD patients by means of real-time PCR. Biopsies of JLD lesions (N = 102) were classified according to their clinical and histopathological features and then analyzed using real-time PCR in order to determine the expression levels of TGF-β1, FoxP3, CTLA4, IKZF2, IL-10, T-bet, IFN-γ, GATA3, IL-4, IL-5, IL-13, IL-33, RORC, IL-17A, IL-17F, and IL-22 and to compare these levels to those of healthy control skin (N = 12). The results showed an increased expression of FoxP3, CTLA4, TGF-β1, IL-10, T-bet, IL-17F, and IL-17A in lesions, while GATA3 and IL-4 levels were found to be lower in diseased skin than in the control group. When the clinical forms were compared, TGF-β1 was found to be highly expressed in patients with a single localized lesion while IL-5 and IL-17A levels were higher in patients with multiple/disseminated lesions. These results demonstrate the occurrence of mixed T helper responses and suggest the dominance of regulatory T cell activity, which could inhibit Th-dependent protective responses to intracellular fungi such as L. loboi. Therefore, Tregs may play a key role in JLD pathogenesis.

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Section: Introductionmentioning

confidence: 99%

Analysis of Immune Response Markers in Jorge Lobo's Disease Lesions Suggests the Occurrence of Mixed T Helper Responses with the Dominance of Regulatory T Cell Activity

et al. 2015

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“…Algumas dermatoses têm seu cuidado compartilhado com outras especialidades, mas o reconhecimento dos seus sinais cutâneos auxilia no diagnóstico e justifica a sua importância para o clínico geral. É o caso do lúpus eritematoso e da dermatomiosite (41)(42)(43)(44)(45)(46).…”

Section: Discussionunclassified

Elaboração de projeto para o ensino médio utilizando a metodologia da aprendizagem baseada em problemas fazendo ciência, investigando doenças = Project development for high school using the problem based learning methodology : Making science, investigating diseases

Ilha¹

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Agradeço primeiramente à minha mãe, por todos os ensinamentos e finais de semana ao meu lado durante o desenvolvimento dessa dissertação. Você é meu orgulho como pessoa e profissional. Não poderia escolher alguém melhor para dividir a minha segunda casa, a Unicamp.Ao meu pai, por me dar forças e me alegrar todos os dias. Obrigada por me ensinar a caminhar pelos labirintos da Plataforma Brasil e ser meu exemplo de pessoa de bom coração, que vê sempre o melhor em todos.Ao meu irmão, pelo constante apoio e sugestões em português e inglês. Obrigada por estar disponível quando eu preciso, a apenas uma mensagem de distância. Sinto sua falta todos os dias! Ao meu amor, por compreender meus momentos de ausência, além de me acompanhar nos melhores e piores momentos dos últimos anos. Obrigada por acreditar que posso conquistar tudo o que desejo.À minha orientadora Dr a Andrea, por confiar e acreditar nesse trabalho e nas minhas ideias, sabendo lidar diariamente com minha teimosia e perfeccionismo.

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