LAC-Depressionsstudie

Beutel, Manfred E.; Bahrke, Ulrich; Fiedler, Georg Martin; Hautzinger, Martin; Kallenbach, Lisa; Kaufhold, Johannes; Keller, Wolfram; Negele, Alexa; Rüger, Bernhard; Leuzinger‐Bohleber, Marianne; Ernst, Mareike

doi:10.1007/s00278-016-0144-x

Cited by 7 publications

(2 citation statements)

References 12 publications

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“…; Benecke, Huber, Schauenburg, & Staats, 2016). On the other hand, we demand more studies of LTPP oriented on current standards of psychotherapy research such as the LAC depression study (Beutel et al, 2016) and the APD study (Benecke, Huber, Staats, et al, 2016) which are currently being conducted. Given the aforementioned necessity of long-term treatments for patients with complex mental disorders, more funds should be provided for such studies.…”

Section: Discussionmentioning

confidence: 99%

“…Only one of the included studies was an RCT, conducted by Huber, Zimmermann, Henrich, and Klug (2012). Currently, Beutel et al (2016) and Benecke, Huber, Staats, et al (2016) each run an RCT comparing long-term cognitive behavioral therapy to long-term psychoanalytic therapy (long-term CBT vs. LTPP and psychoanalysis proper). Their study designs follow the highest standards of current psychotherapy research.…”

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confidence: 99%

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A Series of Meta-Analytic Tests of the Efficacy of Long-Term Psychoanalytic Psychotherapy

Woll

Schönbrodt

2020

European Psychologist

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Abstract. Recent meta-analyses come to conflicting conclusions about the efficacy of long-term psychoanalytic psychotherapy (LTPP). Our first goal was to reproduce the most recent meta-analysis by Leichsenring, Abbass, Luyten, Hilsenroth, and Rabung (2013) who found evidence for the efficacy of LTPP in the treatment of complex mental disorders. Our replicated effect sizes were in general slightly smaller. Second, we conducted an updated meta-analysis of randomized controlled trials comparing LTPP (lasting for at least 1 year and 40 sessions) to other forms of psychotherapy in the treatment of complex mental disorders. We focused on a transparent research process according to open science standards and applied a series of elaborated meta-analytic procedures to test and control for publication bias. Our updated meta-analysis comprising 191 effect sizes from 14 eligible studies revealed small, statistically significant effect sizes at post-treatment for the outcome domains psychiatric symptoms, target problems, social functioning, and overall effectiveness (Hedges’ g ranging between 0.24 and 0.35). The effect size for the domain personality functioning (0.24) was not significant ( p = .08). No signs for publication bias could be detected. In light of a heterogeneous study set and some methodological shortcomings in the primary studies, these results should be interpreted cautiously. In conclusion, LTPP might be superior to other forms of psychotherapy in the treatment of complex mental disorders. Notably, our effect sizes represent the additional gain of LTPP versus other forms of primarily long-term psychotherapy. In this case, large differences in effect sizes are not to be expected.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

A Series of Meta-Analytic Tests of the Efficacy of Long-Term Psychoanalytic Psychotherapy

Woll

Schönbrodt

2020

European Psychologist

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Psychological therapies for treatment-resistant depression in adults

Ijaz

Davies

Williams

et al. 2018

Cochrane Database of Systematic Reviews

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Background Antidepressants are a first-line treatment for adults with moderate to severe major depression. However, many people prescribed antidepressants for depression don't respond fully to such medication, and little evidence is available to inform the most appropriate 'next step' treatment for such patients, who may be referred to as having treatment-resistant depression (TRD). National Institute for 1. Any psychological therapy versus antidepressant treatment alone, or another psychological therapy. 2. Any psychological therapy given in addition to antidepressant medication versus antidepressant treatment alone, or a psychological therapy alone. Primary outcomes required were change in depressive symptoms and number of dropouts from study or treatment (as a measure of acceptability). Data collection and analysis We extracted data, assessed risk of bias in duplicate, and resolved disagreements through discussion or consultation with a third person. We conducted random-effects meta-analyses when appropriate. We summarised continuous outcomes using mean differences (MDs) or standardised mean differences (SMDs), and dichotomous outcomes using risk ratios (RRs). Main results We included six trials (n = 698; most participants were women approximately 40 years of age). All studies evaluated psychotherapy plus usual care (with antidepressants) versus usual care (with antidepressants). Three studies addressed the addition of cognitivebehavioural therapy (CBT) to usual care (n = 522), and one each evaluated intensive short-term dynamic psychotherapy (ISTDP) (n = 60), interpersonal therapy (IPT) (n = 34), or group dialectical behavioural therapy (DBT) (n = 19) as the intervention. Most studies were small (except one trial of CBT was large), and all studies were at high risk of detection bias for the main outcome of self-reported depressive symptoms. A random-effects meta-analysis of five trials (n = 575) showed that psychotherapy given in addition to usual care (vs usual care alone) produced improvement in self-reported depressive symptoms (MD-4.07 points, 95% confidence interval (CI)-7.07 to-1.07 on the Beck Depression Inventory (BDI) scale) over the short term (up to six months). Effects were similar when data from all six studies were combined for self-reported depressive symptoms (SMD-0.40, 95% CI-0.65 to-0.14; n = 635). The quality of this evidence was moderate. Similar moderate-quality evidence of benefit was seen on the Patient Health Questionnaire-9 Scale (PHQ-9) from two studies (MD-4.66, 95% CI 8.72 to-0.59; n = 482) and on the Hamilton Depression Rating Scale (HAMD) from four studies (MD-3.28, 95% CI-5.71 to-0.85; n = 193). High-quality evidence shows no differential dropout (a measure of acceptability) between intervention and comparator groups over the short term (RR 0.85, 95% CI 0.58 to 1.24; six studies; n = 698). Moderate-quality evidence for remission from six studies (RR 1.92, 95% CI 1.46 to 2.52; n = 635) and low-quality evidence for response from four studies (RR 1.80, 95% CI 1.2 to 2.7; n = 556) i...

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Psychodynamische Psychotherapie: Anwendungsprinzipien und Verfahrensformen

Buchheim

2020

Klinische Psychologie &Amp; Psychotherapie

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LAC-Depressionsstudie

Cited by 7 publications

References 12 publications

A Series of Meta-Analytic Tests of the Efficacy of Long-Term Psychoanalytic Psychotherapy

A Series of Meta-Analytic Tests of the Efficacy of Long-Term Psychoanalytic Psychotherapy

Psychological therapies for treatment-resistant depression in adults

Psychodynamische Psychotherapie: Anwendungsprinzipien und Verfahrensformen

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