Labour induction at term: clinical, biophysical and molecular predictive factors

Abstract

The phIGFBP-1 test is a fast and easy test that can be used with Bishop score and IL-8 to reach an high positive predictive value in the prediction of the success of labour induction with prostaglandins.

Insulin‐like growth factor binding protein 1, Bishop score, and sonographic cervical length: tolerability and prediction of vaginal birth and vaginal birth within 24 hours following labour induction in nulliparous women

“…Cheung et al find an even higher phIGFBP‐1 prevalence rate of 77%, whereas Dogl et al report a 29% prevalence rate. The three aforementioned studies and ours all used the Actim ® Partus test kit . It could be relevant that the participants in the study performed by Cheung et al were exclusively Chinese, whereas our study population was performed for multiracial South‐East Asians, in contrast to Dogl et al's study population of 97.7% white women, and Riboni et al's study population of white women only.…”

“…with severe pre‐eclampsia) where there might be a narrow time window for safe delivery, a speedy delivery may be more relevant than an eventual vaginal delivery when making the decision to induce labour as opposed to performing a caesarean delivery. We were limited by not being able to control for other predictors of successful induction, however, such as posterior cervical angle, fetal fibronectin, interleukin 8, and more recently, cervical elastography …”

“…We performed a PubMed search on 7 January 2016 using the search terms ‘insulin growth factor binding protein 1’ OR ‘IGFBP‐1’ AND ‘labor induction’ OR ‘labour induction’, without any limits, which returned 12 articles: only four of these papers that we further discuss below are original reports presenting primary data on IGFBP‐1 as a predictor of inducibility of labour in women with intact membranes …”

“…With multivariate analysis in a study population of 115 women, Riboni et al show that the Bishop score (OR 2.3), phIGFBP‐1 test (OR 11.2), and IL‐8 (OR 6.6) predicted successful induction, and concluded that the phIGFBP‐1 test is a fast and easy test that can be used with the Bishop score and IL‐8 in the prediction of the success of labour induction with prostaglandins. Riboni et al use the beginning of the active phase of labour within 12 hours as the marker of successful labour induction with prostaglandins.…”

“…A 2012 study found that labour was established within 12 hours of induction in 81.8% of women testing positive for phIGFBP‐1, compared with 25.8% of women testing negative for phIGFBP‐1. In this study, 22/115 (19%) of their population tested positive for phIGFBP‐1 . Using the above data as guidance for sample size calculation, and applying an alpha of 0.05 and a power 0.8, six experimental and 25.2 controls (i.e.…”