Laboratory to industrial scale synthesis of chitosan-based nanomaterials: A review

Thirugnanasambandan, Theivasanthi; Gopinath, Subash C.B.

doi:10.1016/j.procbio.2023.04.008

Cited by 16 publications

(4 citation statements)

References 46 publications

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“…The practical application of CS-based macro-, micro-, or nano-particles produced by ionic crosslinking is attracting attention both commercially and industrially [17] because of their intriguing properties for environmental applications, such as in catalytic processes [18,19], contaminant removal [13,14], probiotic encapsulation and release under acid conditions [20], and in biomedical field, where the design of CS-carriers is on the rise because CS behaves as an ideal pH-responsive and sensitive carrier for delivering active ingredients due to the presence of positively charged pendant amino groups [10,17,21], and it is also able to encapsulate and release an active principle, such as curcumin.…”

Section: Preparation Of the Cs-and Cs-cur-based Macrobeadsmentioning

confidence: 99%

“…In this context, CS can be employed as a recyclable green catalyst [5], in supercapacitors and biopolymer batteries, sensors, and water treatment [2,4]. It also finds wide use in cosmetics, agriculture, food technology as food packaging material, and in the biomedical field, particularly in bioimaging, tissue engineering, wound dressing, and the textile industry, as well as in the design and development of drug delivery systems, implants, contact lenses and protein binding [1][2][3][4][10][11][12][13]. In particular, to design controlled release systems of CS-based drugs, the poor barrier and mechanical properties of CS can be modulated and improved by appropriately acting on the crosslinking process, and/or incorporating materials into CS films [3,6].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Sodium Hydroxide and Tripolyphosphate on Curcumin Release from Chitosan-Based Macroparticles

Pistone,

de Gaetano,

Piperopoulos

et al. 2023

Materials

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This work deals with the synthesis of bare and curcumin (CUR)-loaded chitosan (CS)-based macroparticles by ionic gelation using sodium hydroxide (NaOH) or sodium tripolyphosphate (TPP). The resulting spherical-shaped macroparticles were studied using various characterization techniques, Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), and Differential Scanning Calorimetry (DSC). The release of CUR from the CS-based particles with respect to time was analyzed, and the encapsulation efficiency and degree of swelling were studied. All formulations showed excellent CUR trapping efficiency, exceeding 90%. In particular, the TPP-crosslinked macrobeads released 34 wt% of the charged CUR within minutes, while the remaining 66 wt% was released slowly. The results indicate that the correct choice of gelling agent and its concentration leads to spherical particles capable of encapsulating CUR and releasing it in a wide range of kinetics so that macrospheres can be used in different applications.

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Section: Preparation Of the Cs-and Cs-cur-based Macrobeadsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of Sodium Hydroxide and Tripolyphosphate on Curcumin Release from Chitosan-Based Macroparticles

Pistone,

de Gaetano,

Piperopoulos

et al. 2023

Materials

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“…Most of the reported approaches described for the synthesis of chitosan-based nanoparticles are not suitable for large-scale synthesis. Spray drying and ionic gelation methods could potentially be employed for the large-scale synthesis of chitosan nanoparticles, but particle size arising from these production methods shows a greater distribution between 160 nm and 1 µm [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Synthesis of Scalable Layer-by-Layer Multiple Antigen Nano-Delivery Platform for SARS-CoV-2 Vaccines

Xu,

Masuda,

Groso

et al. 2024

Vaccines

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The COVID-19 outbreak was a global pandemic with wide-ranging healthcare implications. Although several mRNA-based vaccines delivered using lipid nanoparticles (LNP) have been approved and demonstrated efficacy at reducing the severity and spread of infection, continued rapid viral evolution and disadvantages currently associated with LNP delivery vehicles (such as toxicity) are driving the design of next-generation SARS-CoV-2 vaccines. Herein, we describe the development of a trimethylated chitosan-based nanoparticle layer-by-layer (LbL) delivery platform for multiple antigens as a scalable and safe COVID-19 vaccine, known as, “LbL-CoV19”. These vaccine candidates have been demonstrated to be biocompatible, safe, and effective at stimulating both humoral and cellular responses for protection in preclinical studies. Preliminary results also indicate that LbL-CoV19 can potentially achieve rapid, long-lasting, and broad protection against the SARS-CoV-2 challenge. The “plug-and-play” platform technology is well suited to preparedness for future pandemics and disease outbreaks.

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“…Derived from chitin, which is predominantly found in the exoskeleton of crustaceans, insects, and the cell walls of fungi, chitosan is the second most abundant natural polysaccharide after cellulose [1][2][3]. Its biodegradability, biocompatibility, non-toxicity, antimicrobial properties, antitumor effect and ability to sensitize tumor therapy [4,5] make it an attractive material for numerous applications, particularly in the food industry and medicine [6][7][8][9]. One of the most noteworthy applications of chitosan is the development of antibacterial films.…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Based Antibacterial Films for Biomedical and Food Applications

Khubiev

Egorov

Kirichuk

et al. 2023

IJMS

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Antibacterial chitosan films, versatile and eco-friendly materials, have garnered significant attention in both the food industry and medicine due to their unique properties, including biodegradability, biocompatibility, and antimicrobial activity. This review delves into the various types of chitosan films and their distinct applications. The categories of films discussed span from pure chitosan films to those enhanced with additives such as metal nanoparticles, metal oxide nanoparticles, graphene, fullerene and its derivatives, and plant extracts. Each type of film is examined in terms of its synthesis methods and unique properties, establishing a clear understanding of its potential utility. In the food industry, these films have shown promise in extending shelf life and maintaining food quality. In the medical field, they have been utilized for wound dressings, drug delivery systems, and as antibacterial coatings for medical devices. The review further suggests that the incorporation of different additives can significantly enhance the antibacterial properties of chitosan films. While the potential of antibacterial chitosan films is vast, the review underscores the need for future research focused on optimizing synthesis methods, understanding structure-property relationships, and rigorous evaluation of safety, biocompatibility, and long-term stability in real-world applications.

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Laboratory to industrial scale synthesis of chitosan-based nanomaterials: A review

Cited by 16 publications

References 46 publications

Effect of Sodium Hydroxide and Tripolyphosphate on Curcumin Release from Chitosan-Based Macroparticles

Effect of Sodium Hydroxide and Tripolyphosphate on Curcumin Release from Chitosan-Based Macroparticles

Microfluidic Synthesis of Scalable Layer-by-Layer Multiple Antigen Nano-Delivery Platform for SARS-CoV-2 Vaccines

Chitosan-Based Antibacterial Films for Biomedical and Food Applications

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