Laboratory Tests in the Diagnosis and Follow-Up of Pediatric Rheumatic Diseases: An Update

Breda, Luciana; Nozzi, Manuela; Sanctis, Sara De; Chiarelli, Francesco

doi:10.1016/j.semarthrit.2008.12.001

Cited by 102 publications

(117 citation statements)

References 159 publications

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“…17 As serum CRP concentration reflects the magnitude of inflammation, it has also become a routine laboratory parameter in daily clinical practice for diagnosis and monitoring of autoimmune inflammatory disorders such as rheumatoid arthritis. 18,19 To render CRP a useful marker in children, age-specific reference values are needed.…”

Section: Introductionmentioning

confidence: 99%

C-reactive protein reference percentiles among pre-adolescent children in Europe based on the IDEFICS study population

et al. 2014

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on behalf of the IDEFICS consortium OBJECTIVES: C-reactive protein (CRP) is involved in a wide range of diseases. It is a powerful marker for inflammatory processes used for diagnostic and monitoring purposes. We aimed to establish reference values as data on the distribution of serum CRP levels in young European children are scarce. SUBJECTS: Reference values of high-sensitivity CRP concentrations were calculated for 9855 children aged 2.0-10.9 years, stratified by age and sex. The children were recruited during the population-based European IDEFICS study (Identification and prevention of Dietary-and lifestyle-induced health Effects in Children and infantS) with 18 745 participants recruited from 2007 to 2010. RESULTS: In 44.1 % of the children, CRP values were below or equal the detection limit of 0.2 mg/l. Median CRP concentrations showed a slight negative age trend in boys and girls, whereas serum CRP values were slightly higher in girls than in boys across all age groups. CONCLUSIONS: Our population-based reference values of CRP may guide paediatric practice as elevated values may require further investigation or treatment. Therefore, the presented reference values represent a basis for clinical evaluation and for future research on risk assessment of diseases associated with increased CRP levels among children.

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Section: Introductionmentioning

confidence: 99%

C-reactive protein reference percentiles among pre-adolescent children in Europe based on the IDEFICS study population

et al. 2014

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“…(42,44) Furthermore, hyperferritinemia (≥2,500 µg/L) was reported to be associated with the relapsing-progressive type of multiple sclerosis, (64) adult-onset Still's disease, (65) primary and secondary hemophagocyticlymphohistiocytosis. (66)(67) Interestingly, low serum ferritin was reported to be associated with a good response to therapy in patients with autoimmune diseaseassociated hemophagocytic syndrome (66)(67) that usually presents with hyperferritinemia (> 500 µg/L), high fever, hepatosplenomegaly, lymphadenopathy, central nervous system involvement and disseminated intravascular coagulation. (68) Based on that, significant clearance of serum ferritin in patients having autoimmune diseases using Al-hijamah is so beneficial in correcting the pathogenesis in such patients and in restoring physiological homeostasis (Fig.…”

Section: Therapeutic Importance Of Clearing Ferritin In Autoimmune DImentioning

confidence: 99%

Ameliorating Role Exerted by Al-Hijamah in Autoimmune Diseases : Effect on Serum Autoantibodies and Inflammatory Mediators

Baghdadi

Abdelaziz²,

Ahmed

et al. 2015

IJHS

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Autoimmune diseases have common properties characterized by abnormal blood chemistry with high serum autoimmune antibodies, and inflammatory mediators. Those causative pathological substances (CPS) cannot be excreted by physiological mechanisms. Current treatments for autoimmune diseases involve steroids, cytotoxic drugs, plasmapheresis and monoclonal antibodies. Wet cupping therapy (WCT) of prophetic medicine is called Al-hijamah that treats numerous diseases having different etiology and pathogenesis via a pressure-dependent and size-dependent non-specific filtration then excretion of CPS causing clearance of blood and interstitial fluids. Al-hijamah clears blood passing through the fenestrated skin capillaries. Medical bases of Al-hijamah were reported in the evidence-based Taibah mechanism (Taibah theory). Al-hijamah was reported to be an excellent treatment for rheumatoid arthritis that improved patients' blood chemistry and induced significant clinical improvement and pharmacological potentiation. Al-hijamah improved the natural immunity and suppressed the pathological immunity through decreasing the serum level of autoantibodies, inflammatory mediators, and serum ferritin (a key player in autoimmunity). Al-hijamah reduced significantly pain severity, number of swollen joints and disease activity with no significant side effects. Main steps of Al-hijamah are skin suction (cupping), scarification (sharatmihjam in Arabic) and second suction (triple S technique) that is better therapeutically than the traditional WCT (double S technique). Whenever an excess noxious substance is to be removed from patients' blood and interstitial fluids, Al-hijamah is indicated.Shartatmihjam is a curative treatment in prophetic teachings according to the prophetic hadeeth: "Cure is in three: in shartatmihjam, oral honey and cauterization. I do not recommend my nation to cauterize".Al-hijamah may have better therapeutic benefits than plasmapheresis. Al-hijamah may be promising in treating autoimmune diseases as a sole treatment or adjuvant treatment.

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“…Not all tests could be analyzed as result of the reduced sample size. Instead, eight of the most frequently-used laboratory tests that are part of the classification criteria to diagnose SLE or MCTD were included in the ROC curve analysis (FANA titers, dsDNA ELISA, elevated serum DNA titers and positive results for RNP, Sm, SSA, SSB and Scl-70) (Egner, 2000;Mahler et al, 2005;Isenberg et al, 2007;Breda et al, 2010). When using the subset of individuals for whom clinical test results were available (SLE = 59 and MCTD = 24), the IgM anti-P4/P10 titers and IgM anti-P1 reactivity displayed the greatest discrimination capacity to classify SLE and MCTD patients (p ≤ 0.05) ( Figure 7 and Appendix 2).…”

Section: Comparing the Power Of Igm Anti-p4/p10 With Conventional CLImentioning

confidence: 99%

“…It is not surprising that the dsDNA test contributes to the differentiation of these diseases given that antibodies against DNA have been detected in approximately 70% of SLE patients and shows 95% specificity for this disorder (Reveille, 2004;Breda et al, 2010). Yet, the fact that the dsDNA test alone exhibits a lower ability to segregate SLE and MCTD patients (66.4%) than the IgM anti-P4/P10 system (73.1%), indicates the significant contribution of this ELISA-based system in discerning between these two maladies ( Figure 7).…”

Section: Improving the Discriminatory Capacity Of Igm Anti-p4/p10 Titersmentioning

confidence: 99%

“…Nevertheless, the concept of MCTD has been reported as a useful definition in clinical practice (Zdrojewicz et al, 1999;Venables, 2006;von Bierbrauer et al, 2008;NowickaSauer et al, 2012), and clinical and serological features segregate the two illnesses (Isenberg et al, 2007;Breda et al, 2010). The American College of Rheumatology (ACR) has created universal classification parameters for SLE (Hochberg, 1997);…”

Section: Introductionmentioning

confidence: 99%

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Auto-antigenic Properties of the Spliceosome as a Molecular Tool for Diagnosing Systemic Lupus Erythematosus and Mixed Connective Tissue Disease Patients

Mesa¹

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Laboratory Tests in the Diagnosis and Follow-Up of Pediatric Rheumatic Diseases: An Update

Cited by 102 publications

References 159 publications

C-reactive protein reference percentiles among pre-adolescent children in Europe based on the IDEFICS study population

C-reactive protein reference percentiles among pre-adolescent children in Europe based on the IDEFICS study population

Ameliorating Role Exerted by Al-Hijamah in Autoimmune Diseases : Effect on Serum Autoantibodies and Inflammatory Mediators

Auto-antigenic Properties of the Spliceosome as a Molecular Tool for Diagnosing Systemic Lupus Erythematosus and Mixed Connective Tissue Disease Patients

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