Laboratory test alterations in patients with COVID-19 and non COVID-19 interstitial pneumonia: a preliminary report

Paliogiannis, Panagiotis; Zinellu, Angelo; Scano, Valentina; Mulas, Giulia; Riu, Giacomo De; Pascale, Rosa M.; Arru, Luigi Benedetto; Carru, Ciriaco; Pirina, Pietro; Mangoni, Arduino A.; Fois, Alessandro Giuseppe

doi:10.3855/jidc.12879

Cited by 56 publications

(69 citation statements)

References 25 publications

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“…Dynamic monitoring of the inflammation process might be better in predicting the prognosis. Moreover, the results of our study were different from those of previous studies [1,29]. One reason was that there were some missing data in the laboratory results.…”

Section: Plos Onecontrasting

confidence: 99%

The independent factors associated with oxygen therapy in COVID-19 patients under 65 years old

Wang

Liang

et al. 2021

PLoS ONE

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Background The number of hospitalized young coronavirus disease 2019 (COVID-19) patients has increased significantly. However, specific data about COVID-19 patients under 65 years old who are admitted to the hospital are scarce. Methods The COVID-19 patients under 65 years old who were admitted to the hospital in Sichuan Province, Renmin Hospital of Wuhan University, and Wuhan Red Cross Hospital were included in this study. Demographic information, laboratory data and clinical treatment courses were extracted from electronic medical records. Risk factors associated with oxygen therapy were explored. Results Eight hundred thirty-three COVID-19 patients under 65 years old were included. Of the included patients, 29.4% had one or more comorbidities. Oxygen therapy was required in 63.1% of these patients, and the mortality was 2.9% among the oxygen therapy patients. Fever (odds ratio [OR] 2.072, 95% confidence interval [CI] 1.312–3.271, p = 0.002), dyspnea (OR 2.522, 95% CI 1.213–5.243, p = 0.013), chest distress (OR 2.278, 95% CI 1.160–4.473, p = 0.017), elevated respiratory rate (OR 1.114, 95% CI 1.010–1.228, p = 0.031), and decreased albumin (OR 0.932, 95% CI 0.880–0.987, p = 0.016) and globulin levels (OR 0.929, 95% 0.881–0.980, p = 0.007) were independent factors related to oxygen therapy. Conclusions Oxygen therapy is highly required in COVID-19 patients under 65 years old who are admitted to the hospital, but the success rate is high. Respiratory failure-related symptoms, elevated respiratory rate, low albumin and globulin levels, and fever at admission are independent risk factors related to the requirement of oxygen.

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Section: Plos Onecontrasting

confidence: 99%

The independent factors associated with oxygen therapy in COVID-19 patients under 65 years old

Wang

Liang

et al. 2021

PLoS ONE

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“…This, the consequent lack of information regarding the pathophysiology and clinical progress, prevented the establishment and implementation of adequate public health responses. Several studies have described alterations in routine laboratory tests in patients affected by COVID-19, including a decrease in serum albumin concentrations [8][9][10][11]. However, no pooled analyses of the available evidence have been performed to accurately estimate the effect size of such reduction, to investigate its relationship with disease severity and outcomes and to evaluate which parameters may affect the effect size.…”

Section: Discussionmentioning

confidence: 99%

“…There are ongoing efforts to better understand the pathophysiology, presentation and clinical outcomes of the disease, including the identification of biomarkers for diagnosis, risk stratification, disease monitoring and prognosis. Early studies in COVID-19 patients have reported alterations in routine laboratory tests, particularly white blood cell count, neutrophils, lymphocytes, platelets, alanine aminotransferase, aspartate aminotransferase, D-dimer, total bilirubin and creatinine [8][9][10][11]. Reductions in serum albumin concentrations have also been associated with disease severity [12,13].…”

Section: Introductionmentioning

confidence: 99%

Serum albumin concentrations are associated with disease severity and outcomes in coronavirus 19 disease (COVID-19): a systematic review and meta-analysis

et al. 2021

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Coronavirus disease 2019 (COVID-19), an infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is responsible for the most threatening pandemic in modern history. The aim of this systematic review and meta-analysis was to investigate the associations between serum albumin concentrations and COVID-19 disease severity and adverse outcomes. A systematic literature search was conducted in PubMed, from inception to October 30, 2020. Sixty-seven studies in 19,760 COVID-19 patients (6141 with severe disease or poor outcome) were selected for analysis. Pooled results showed that serum albumin concentrations were significantly lower in patients with severe disease or poor outcome (standard mean difference, SMD: − 0.99 g/L; 95% CI, − 1.11 to − 0.88, p < 0.001). In multivariate meta-regression analysis, age (t = − 2.13, p = 0.043), publication geographic area (t = 2.16, p = 0.040), white blood cell count (t = − 2.77, p = 0.008) and C-reactive protein (t = − 2.43, p = 0.019) were significant contributors of between-study variance. Therefore, lower serum albumin concentrations are significantly associated with disease severity and adverse outcomes in COVID-19 patients. The assessment of serum albumin concentrations might assist with early risk stratification and selection of appropriate care pathways in this group.

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“…Several clinical and demographic factors have been shown to be significantly associated with measures of coronavirus disease 2019 (COVID-19) severity, based on clinical and imaging findings and/or the need for aggressive single- and multi-organ support, and mortality [ 1 , 2 ]. The evidence of excessive inflammatory activity in severe COVID-19, captured during the early phases of the pandemic, prompted the investigation of the clinical role of specific biomarkers of inflammatory and immunomodulating pathways, particularly C-reactive protein (CRP), white blood cell count (WBC), neutrophils, lymphocytes, platelets, procalcitonin, ferritin, and serum amyloid A [ [3] , [4] , [5] , [6] ]. Additional research has shown that patients with COVID-19 can also experience structural and functional abnormalities of specific organs and systems, e.g., cardiovascular, hematological, gastrointestinal, and neurological, in addition to the well-known respiratory compromise, characterized by the development of interstitial pneumonia and acute respiratory distress syndrome (ARDS) [ [7] , [8] , [9] ].…”

Section: Introductionmentioning

confidence: 99%

Serum CK-MB, COVID-19 severity and mortality: An updated systematic review and meta-analysis with meta-regression

Zinellu

Sotgia

Fois

et al. 2021

Advances in Medical Sciences

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Objectives We conducted a systematic review and meta-analysis with meta-regression of creatine kinase-MB (CK-MB), a biomarker of myocardial injury, in COVID-19 patients. Methods We searched PubMed, Web of Science and Scopus, for studies published between January 2020 and January 2021 that reported CK-MB, COVID-19 severity and mortality (PROSPERO registration number: CRD42021239657). Results Fifty-five studies in 11,791 COVID-19 patients were included in the meta-analysis. The pooled results showed that CK-MB concentrations were significantly higher in patients with high disease severity or non-survivor status than patients with low severity or survivor status (standardized mean difference, SMD, 0.81, 95% CI 0.61 to 1.01, p<0.001). The rate of patients with CK-MB values above the normal range was also significantly higher in the former than the latter (60/350 vs 98/1,780; RR=2.84, 95%CI 1.89 to 4.27, p<0.001; I 2 =19.9, p=0.254). Extreme between-study heterogeneity was observed (I 2 =93.4%, p<0.001). Sensitivity analysis, performed by sequentially removing each study and re-assessing the pooled estimates, showed that the magnitude and direction of the effect size was not modified (effect size range, 0.77 to 0.84). Begg's (p=0.50) and Egger's (p=0.86) t-tests did not show publication bias. In meta-regression analysis, the SMD was significantly and positively associated with the white blood count, aspartate aminotransferase, myoglobin, troponin, brain natriuretic peptide, lactate dehydrogenase, and D-dimer. Conclusions Higher CK-MB concentrations were significantly associated with severe disease and mortality in COVID-19 patients. This biomarker of myocardial injury might be useful for risk stratification in this group.

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Laboratory test alterations in patients with COVID-19 and non COVID-19 interstitial pneumonia: a preliminary report

Cited by 56 publications

References 25 publications

The independent factors associated with oxygen therapy in COVID-19 patients under 65 years old

The independent factors associated with oxygen therapy in COVID-19 patients under 65 years old

Serum albumin concentrations are associated with disease severity and outcomes in coronavirus 19 disease (COVID-19): a systematic review and meta-analysis

Serum CK-MB, COVID-19 severity and mortality: An updated systematic review and meta-analysis with meta-regression

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