Laboratory Puzzle of Oxidative Stress, Parameters of Hemostasis and Inflammation in Hospitalized Patients with COVID-19

Djordjevic, Jelena; Ignjatovic, Vesna; Vukomanovic, Vladimir; Vuleta, Katarina; Ilic, Nevenka; Slovic, Zivana; Stanojevic Pirkovic, Marijana; Mihaljevic, Olgica

doi:10.3390/biomedicines12030636

Cited by 2 publications

References 37 publications

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Oxidative stress markers and prediction of severity by a machine learning approach in hospitalized patients with COVID-19 and severe lung disease: a feasibility study (Preprint)

RASPADO,

BRACK,

BRACK

et al. 2024

Preprint

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BACKGROUND Oxidative Stress (OS) is an imbalance between the production of free radicals and the body's ability to neutralize them, leading to damages of cells, proteins and deoxyribonucleic. OBJECTIVE To identify the relevant biomarkers of OS which could be associated to severity of hospitalized patients and to identify a possible correlation between OS biomarkers and clinical status of hospitalized COVID-19 patients with severe lung disease at hospital admission. METHODS All adult patients hospitalized with COVID-19 at the Infirmerie Protestante (Lyon, France) from 9th February 2022 to 18th May 2022 were included, regardless of the care service. The final sample consisted in 28 patients. Ten biomarkers were collected per patient (Zinc (Zn), Copper (Cu), Cu/Zn, Selenium, Uric acid, CRplus, Oxidized LDL, Glutathione peroxidase, Glutathione reductase and Thiols), as well as demographic variables and comorbidities. A support vector machine (SVM) model was used to predict the severity grade per patient, based on the collected data as training set. RESULTS : Three biomarkers of OS were associated with severity; Zn, Cu/Zn and Thiols especially for grade 0 (asymptomatic) and grade 1 (mild to moderate severity). The SVM model predicted the level of severity from the biological analysis of the OS biomarkers with only 7.14% of discrepancy in the training dataset. CONCLUSIONS In case of COVID-19 infection, moderate to severe symptomatic patients are associated with a lowered zinc level, a lowered plasma thiol level, an increased CRPus and an increased Cu/Zn ratio among a panel of ten biomarkers of OS.

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Oxidative stress markers and prediction of severity by a machine learning approach in hospitalized patients with COVID-19 and severe lung disease: a feasibility study (Preprint)

RASPADO,

BRACK,

BRACK

et al. 2024

Preprint

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Increased Oxidative Stress and Decreased Citrulline in Blood Associated with Severe Novel Coronavirus Pneumonia in Adult Patients

Tsuge,

Ichihara,

Hasegawa

et al. 2024

IJMS

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This study investigated the correlation between oxidative stress and blood amino acids associated with nitric oxide metabolism in adult patients with coronavirus disease (COVID-19) pneumonia. Clinical data and serum samples were prospectively collected from 100 adult patients hospitalized for COVID-19 between July 2020 and August 2021. Patients with COVID-19 were categorized into three groups for analysis based on lung infiltrates, oxygen inhalation upon admission, and the initiation of oxygen therapy after admission. Blood data, oxidative stress-related biomarkers, and serum amino acid levels upon admission were compared in these groups. Patients with lung infiltrations requiring oxygen therapy upon admission or starting oxygen post-admission exhibited higher serum levels of hydroperoxides and lower levels of citrulline compared to the control group. No remarkable differences were observed in nitrite/nitrate, asymmetric dimethylarginine, and arginine levels. Serum citrulline levels correlated significantly with serum lactate dehydrogenase and C-reactive protein levels. A significant negative correlation was found between serum levels of citrulline and hydroperoxides. Levels of hydroperoxides decreased, and citrulline levels increased during the recovery period compared to admission. Patients with COVID-19 with extensive pneumonia or poor oxygenation showed increased oxidative stress and reduced citrulline levels in the blood compared to those with fewer pulmonary complications. These findings suggest that combined oxidative stress and abnormal citrulline metabolism may play a role in the pathogenesis of COVID-19 pneumonia.

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Laboratory Puzzle of Oxidative Stress, Parameters of Hemostasis and Inflammation in Hospitalized Patients with COVID-19

Cited by 2 publications

References 37 publications

Oxidative stress markers and prediction of severity by a machine learning approach in hospitalized patients with COVID-19 and severe lung disease: a feasibility study (Preprint)

Oxidative stress markers and prediction of severity by a machine learning approach in hospitalized patients with COVID-19 and severe lung disease: a feasibility study (Preprint)

Increased Oxidative Stress and Decreased Citrulline in Blood Associated with Severe Novel Coronavirus Pneumonia in Adult Patients

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