Laboratory monitoring of successful COVID-19 as part of the in-depth medical care project «Healthy Moscow»

Abstract

Introduction. After COVID-19, survivors often report post-COVID syndrome (PCS), which presents with a wide range of new, recurring, or ongoing symptoms lasting weeks or months after exposure to SARS-CoV-2. PCS is a poorly understood condition due to chronic, mild inflammation theorized as a pathophysiological mechanism.Aim. Our goal is to search for biomarkers for accurate identification of PCD, its treatment and prevention in men of different ages who recovered from COVID-19 as a result of SARS-CoV-2 Delta and Omicron.Materials and methods. The study is based on data from a population cohort study of the health status of Muscovites aged 18 years and over during in-depth medical examinations. Participants had a history of a positive SARS-CoV-2 test result or a diagnosis of COVID-19 that was at least 60 days after recovery. He completed a list of laboratory tests: complete blood count, ESR (in 2022), D-dimer and 7 biochemical biomarkers. Men were divided into age groups: 18-39, 40-59, 60+ years old. We recorded the values of the norm, above the norm, critically above the norm, below the norm and critically below the norm.Results. Statistically significant laboratory parameters with abnormal values were determined: leukocytes, lymphocytes, monocytes, eosinophils, hemoglobin, platelets, D-dimer, cholesterol, LDL, CRP, ALT, AST, LDH, creatinine (p < 0.01%).Discussion. An abbreviated working list of laboratory biomarkers for the primary sorter of PKC in men of different age groups was developed: “18-39 years old” - cholesterol, LDL, ALT, AST and CRP (p < 1%); «40-59 years old» - cholesterol, LDL, D-dimer, CRP, ALT, AST and ESR (p < 1%); «60+ years old» - D-dimer, cholesterol, LDL, ESR, CRP, creatinine, AST, Їplatelets and leukocytes (p < 1%).Conclusion. Monitoring the values of the established list of biomarkers is effective for the initial adequate sorting of men after COVID-19 who need dispensary observation and rehabilitation.