2004
DOI: 10.1161/01.cir.0000122869.59485.36
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Laboratory Markers in the Diagnosis of Venous Thromboembolism

Abstract: Abstract-Selected blood tests may be useful in the diagnosis of venous thromboembolism (VTE), or in the identification of a congenital or acquired defect associated with the development of VTE. Several studies have shown the D-dimer assay to have a high negative predictive value but poor specificity when used in the detection of VTE. Yet in the emergency room setting, the D-dimer test may be useful if a detailed risk factor analysis for each patient is included in the diagnosis. The presence of such genetic th… Show more

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Cited by 87 publications
(60 citation statements)
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“…25 In addition, combined genetic prothrombotic risk factors have been shown to increase the risk for thrombus recurrence in children as well as adults. 35,36 We classify children with the above clinical characteristics as high risk and give careful consideration to initial therapy with TPA thrombolysis. Based on our published experience, we usually begin systemic TPA for thrombi with symptomatic onset less than 14 days before initiation of treatment, and local thrombolysis with thrombectomy via interventional radiology for longer-seated thrombi or severe clinical presentations.…”
Section: Rationale For Risk Stratification Upon Which To Base Choice mentioning
confidence: 99%
“…25 In addition, combined genetic prothrombotic risk factors have been shown to increase the risk for thrombus recurrence in children as well as adults. 35,36 We classify children with the above clinical characteristics as high risk and give careful consideration to initial therapy with TPA thrombolysis. Based on our published experience, we usually begin systemic TPA for thrombi with symptomatic onset less than 14 days before initiation of treatment, and local thrombolysis with thrombectomy via interventional radiology for longer-seated thrombi or severe clinical presentations.…”
Section: Rationale For Risk Stratification Upon Which To Base Choice mentioning
confidence: 99%
“…These thrombophilic conditions include hereditary deficiencies of protein S, protein C, and antithrombin; factor V Leiden; the prothrombin G20210A mutation; high levels of clotting factors VIII, IX, and XI; and antiphospholipid antibodies. 1 Hereditary deficiencies of protein S, protein C, and antithrombin have been recognized as the most potent thrombophilic conditions for VTE. [2][3][4][5][6] Recently, we demonstrated that the concomitance of other thrombophilic defects further enhances the risk of VTE associated with these deficiencies.…”
mentioning
confidence: 99%
“…Brief accounts of this work were given elsewhere. [42] Figure 3 shows the preliminary results obtained for the total cross sections with t-channel isospin 0 and 1: We include pre-asymptotic contributions and assume that the Regge parametrization yields a decent approximation above 1.7 GeV. At lower energies, the uncertainties in that representation become larger than those in the sum over the partial waves, which is also shown.…”
Section: On the Working Benchmentioning
confidence: 95%