Laboratory Indicators for Early Detection and Surgical Treatment of Vibrio Necrotizing Fasciitis

Tsai, Yuan-Hsiung; Hsu, Robert Wen Wei; Huang, Kuo Chin; Huang, Tiao‐Lai

doi:10.1007/s11999-010-1311-y

Cited by 70 publications

(67 citation statements)

References 31 publications

(52 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Consistent with our findings for multifocal NF, thrombocytopenia has also been a predictive factor for mortality in monofocal necrotizing deep soft tissue [23, 24]. Physicians should be aware of the grave prognosis for patients with SMNF of the bilateral lower limbs and who present with thrombocytopenia.…”

Section: Discussionsupporting

confidence: 87%

Synchronous multifocal necrotizing fasciitis prognostic factors: a retrospective case series study in a single center

Lee

Huang

et al. 2016

Infection

Self Cite

View full text Add to dashboard Cite

PurposeNo reports have been published on synchronous multifocal necrotizing fasciitis (SMNF), a multifocal presence of necrotizing fasciitis in different extremities. We evaluated the clinical characteristics and outcomes of SMNF.MethodsEighteen patients (14 men, 4 women; mean age: 59 years) diagnosed with SMNF of the extremities between January 2004 to December 2012 were enrolled and evaluated.Results Vibrio species were the most commonly (78%; n = 14) isolated; others were two cases (11%) of Aeromonas spp., one case (6%) of group A β-hemolytic streptococcus, and one case of coagulase-negative staphylococcus. SMNF was in the bilateral lower limbs (72%; n = 13), bilateral upper limbs (17%; n = 3), and one patient with one upper and one lower limb (11%). Non-surviving patients had more bilateral lower limb involvement and thrombocytopenia.ConclusionsMost patients with SMNF were male and had bilateral lower limb and marine Gram-negative bacteria involvement. The mortality of SMNF remained extremely high in patients with involvement of bilateral lower limb and initial thrombocytopenia.

show abstract

Section: Discussionsupporting

confidence: 87%

Synchronous multifocal necrotizing fasciitis prognostic factors: a retrospective case series study in a single center

Lee

Huang

et al. 2016

Infection

Self Cite

View full text Add to dashboard Cite

show abstract

“…Most of our patients lived near the ocean and worked in fisheries, which is in support of the abovementioned findings . Tsai et al reported that among patients with Vibrio NF, a systolic blood pressure of 90 mmHg, low platelet count, and a combination of hepatic dysfunction were associated with a higher mortality rate [17]. Although Vibrio NF has high mortality, our study showed that this had no clinical correlation with mortality in late amputation.…”

Section: Discussioncontrasting

confidence: 61%

Risk factors for mortality in the late amputation of necrotizing fasciitis: a retrospective study

et al. 2018

View full text Add to dashboard Cite

BackgroundNecrotizing fasciitis (NF) is a rapidly progressive infectious disease that primarily involves the fascia and subcutaneous tissue. If not promptly treated, it can lead to morbidity as well as mortality. It can affect any part of the body, most commonly the extremities. Early and aggressive surgical treatment is the proper way of management. The purpose of this study was to identify the risk factors for mortality in late amputation among NF patients that may be used in routine clinical practice to prevent mortality.MethodsA retrospective cohort study of hospitalized patients with NF was conducted in a tertiary teaching hospital in Taiwan between March 2015 and March 2018. All collected data were statistically analyzed.ResultsA total of 582 patients with NF were included; 35 of them had undergone amputation (7 primary and 28 late amputations), with a 6% amputation rate. Thirteen amputated patients still died eventually (all in the late amputation group). Significant risk factors for mortality identified in the late amputation group included hemorrhagic bullae (p = 0.001, OR 4.7, 95% confidence interval (CI) 2.68–8.69), peripheral vascular disease (p < 0.001, OR 3.2, 95% CI 1.12–10.58), bacteremia (p = 0.021, OR 2.87, 95% CI 2.07–5.96), and Laboratory Risk Indicator of Necrotizing Fasciitis (LRINEC) score > 8 (p < 0.001, OR 1.97, 95% CI 1.28–4.61). Vibrio vulnificus was the main causative organism based on our study, but the microbiology results showed no significant correlation.ConclusionNF patients with hemorrhagic bullae, comorbidity with peripheral vascular disease, presence of bacteremia, or LRINEC score > 8 should receive early and primary amputation in order to prevent mortality.

show abstract

“…Many studies by Park et al [16], Hsiao et al [17], Huang et al [18], Frazee B et al [19], Dworkin M et al [20], Singh G et al [21], Shimizu T [22] , et al and Hakkarainen TW et al [23] have documented trauma including operative trauma with mono or polymicrobial infections, consumption of raw or undercooked seafood or injury by fish fins, seawater contamination of wounds infected with marine organisms as common aetiological factors. Many other authors [24][25][26][27][28][29] also reported similar conclusions on various spectrums of synergistic pathogenesis with polymicrobial infections including marine organisms in NF. However, there are increasing reports of NF caused by monomicrobial infection, especially in Asia [27].…”

Section: Introductionsupporting

confidence: 58%

Early diagnosis and management of Necrotizing Fasciitis

Kannan¹,

Kannan²,

Rohan³

et al. 2016

IOSR

View full text Add to dashboard Cite

Laboratory Indicators for Early Detection and Surgical Treatment of Vibrio Necrotizing Fasciitis

Abstract: Level III Prognostic study. See the Guidelines for Authors for complete descriptions of levels of evidence.

Cited by 70 publications

References 31 publications

Synchronous multifocal necrotizing fasciitis prognostic factors: a retrospective case series study in a single center

Synchronous multifocal necrotizing fasciitis prognostic factors: a retrospective case series study in a single center

Risk factors for mortality in the late amputation of necrotizing fasciitis: a retrospective study

Early diagnosis and management of Necrotizing Fasciitis

Contact Info

Product

Resources

About