Laboratory Identification of
            <i>Torulopsis glabrata:</i>
            Typical Appearance on Routine Bacteriological Media

Candida (Torulopsis) glabrata is a fungus with a diversity of habitats and an enlarging clinical spectrum. It is found as normal human flora in the gastrointestinal tract, skin, and vagina and also found in nature in soil and in animals. It was initially thought to represent a nonpathogenic saprophyte, however, it has been recovered with increasing frequency from clinical specimens. It is now recognized as a cause of disease in the normal and compromised host.

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In Vitro Sensitivity of Torulopsis glabrata to Amphotericin B, 5-Fluorocytosine, and Clotrimazole (Bay 5097)

Marks

Steer

Eickhoff

1971

Appl Microbiol

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Thirty-five strains of Torulopsis glabrata were tested by a tube dilution method for their susceptibility to amphotericin B, 5-fluorocytosine, and clotrimazole (Bay 5097). Amphotericin B was the most active in vitro, inhibiting all strains at a concentration of 1 μg/ml and killing all strains at 2 μg/ml. 5-Fluorocytosine inhibited over 80% of strains at 0.24 μg/ml, but three strains required ≥7.8 μg/ml for killing. A concentration of 2 μg of clotrimazole per ml inhibited less than 50% of strains, and 8 μg/ml killed only 10% of strains. Most strains of T. glabrata were killed by therapeutically achievable concentrations of amphotericin B and 5-fluorocytosine, but not clotrimazole.

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Laboratory Identification of Torulopsis glabrata: Typical Appearance on Routine Bacteriological Media

Abstract: The colonial morphology of the yeast Torulopsis glabrata on sheep blood-agar is characteristic and was useful in the identification of 24% of clinical isolates.

Cited by 7 publications

References 7 publications

Novel microtiter plate format for testing germ tube formation and proposal of a cost-effective scheme for yeast identification in a clinical laboratory

Novel microtiter plate format for testing germ tube formation and proposal of a cost-effective scheme for yeast identification in a clinical laboratory

Candida (Torulopsis) glabrata

In Vitro Sensitivity of Torulopsis glabrata to Amphotericin B, 5-Fluorocytosine, and Clotrimazole (Bay 5097)

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