Abstract:The susceptibilities of various clinical isolates to tobramycin were studied, and the applicability of these data to clinical situations was evaluated. The bactericidal nature of tobramycin was confirmed by killing curves, and the minimal inhibitory concentrations for 500 common pathogens were used to define its spectrum. Isolates inhibited by less than or equal to 5 mug/ml were considered to be sensitive to tobramycin. The clinical response of some patients was examined in relation to the minimal inhibitory c… Show more
“…Such crude preparations could, in time, possibly be replaced by a purified version. Such a technique would overcome the criticisms of the currently used methods of determining MBC values or estimating survival numbers where no thought is given to the possibility of the effect of the antibiotic on recovery of treated cells (Linzenmeier et al 1976;McAllister & Tait 1976;Sanders & Sanders 1976;Shadomy et al 1976).…”
Section: (Ii) a Rninog!vcoside-aminocyclitoi Antibioticsmentioning
“…Such crude preparations could, in time, possibly be replaced by a purified version. Such a technique would overcome the criticisms of the currently used methods of determining MBC values or estimating survival numbers where no thought is given to the possibility of the effect of the antibiotic on recovery of treated cells (Linzenmeier et al 1976;McAllister & Tait 1976;Sanders & Sanders 1976;Shadomy et al 1976).…”
Section: (Ii) a Rninog!vcoside-aminocyclitoi Antibioticsmentioning
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