Laboratory Evaluation of Renal Disease in Childhood

Noone, Damien; Langlois, Valérie S.

doi:10.1007/978-3-662-52972-0_3

Cited by 3 publications

(4 citation statements)

References 192 publications

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“…A spot protein/creatinine ratio was elevated at 169.8 mg/mmol (normal range is <20 mg/mmol; nephrotic-range proteinuria is >200 mg/mmol). 1 Urine microscopy revealed numerous uniform red cells, with no red cell casts, compatible with a nonglomerular source.…”

Section: Case Presentationmentioning

confidence: 94%

Idiopathic Urinary Bladder Perforation in Early Childhood

Alshareef

Almaiman

Figueroa

et al. 2018

Kidney International Reports

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Section: Case Presentationmentioning

confidence: 94%

Idiopathic Urinary Bladder Perforation in Early Childhood

Alshareef

Almaiman

Figueroa

et al. 2018

Kidney International Reports

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“…There are important clinical implications for the measurement of PRC and SA levels in neonates. PRA can be used to distinguish between volume-dependent hypertension (suppressed renin) and hyper-reninemic hypertension, which can affect hypertension management [ 31 ]. Previous literature recommends screening neonates with sodium and potassium derangements for PRA but not for hypertension [ 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…Assessing renin and aldosterone is useful in the diagnostic and management consideration of neonates with renal hypertension and some electrolyte derangements; however, there is limited literature on the normative levels of PRA and SA in the term neonate, and very little in premature neonates. A prominent renal physiology textbook in the modern era [ 31 ] still cites old studies from the 1970s for the normal ranges of PRA [ 16 , 23 ]. Furthermore, there is currently no study reporting direct plasma renin concentration (PRC) for neonates.…”

Section: Introductionmentioning

confidence: 99%

Normative values of renin and aldosterone in clinically stable preterm neonates

Bariciak

Harrison

et al. 2022

Pediatr Nephrol

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Background There is a paucity of literature on the normative levels of plasma renin concentration (PRC) and serum aldosterone (SA) in premature neonates. This study aims to provide normative data on PRC and SA levels in preterm neonates in the first 2 weeks after birth and explore associations with maternal, perinatal, or postnatal factors. Methods Neonates born at 26- to 34-week gestation were recruited from two neonatal intensive care units in Canada and Australia. The direct renin assay PRC and SA were analyzed on day 1 and days 14–21 after birth to compare across categorical variables and to produce normative values. Results A total of 262 subjects were enrolled from the Canadian (29%) and Australian (71%) sites. The mean gestational age was 30 weeks, with a mean birth weight of 1457 g. The normative values of PRC and SA for neonates born between 26 + 0 and 29 + 6 weeks and 30 + 0 and 34 + 0 weeks of gestation were produced for day 1 and day 14–21 after birth. Both PRC and SA increased from day 1 to day 14–21. The more premature neonates reached a higher PRC on days 14–21 after birth but exhibited lower SA levels on day 1 after birth. When comparing gender, birth weight, and maternal risk factor categories, no statistical differences in PRC or SA were found. A small but significant decrease in PRC, but not SA, was noted for neonates with placental pathology. Conclusions This study produced normative values of PRA and SA in clinically stable preterm neonates that can be referenced for use in clinical practice. Graphical Abstract

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“…The kidney function test result play a significant role in the early phase treatment of renal diseases. Multiple tests like urinalysis, urinary composition, creatinine clearance, glomerular filtration rate, plasma creatinine, blood urea nitrogen are typically described in kidney function tests that involve both urine and blood samples [ 10 ]. The most significant of such measures are blood urea nitrogen and serum creatinine that are commonly used for monitoring renal function in every clinical laboratory.…”

Section: Introductionmentioning

confidence: 99%

Recent advancements in urea biosensors for biomedical applications

Singh

Sharma

Singh

2021

IET Nanobiotechnology

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The quick progress in health care technology as a recurrent measurement of biochemical factors such as blood components leads to advance development and growth in biosensor technology necessary for effectual patient concern. The review wok of authors present a concise information and brief discussion on the development made in the progress of potentiometric, field effect transistor, graphene, electrochemical, optical, polymeric, nanoparticles and nanocomposites based urea biosensors in the past two decades. The work of authors is also centred on different procedures/methods for detection of urea by using amperometric, potentiometric, conductometric and optical processes, where graphene, polymer etc. are utilised as an immobilised material for the fabrication of biosensors. Further, a comparative revision has been accomplished on various procedures of urea analysis using different materials-based biosensors, and it discloses that electrochemical and potentiometric biosensor is the most promise one among all, in terms of rapid response time, extensive shelf life and resourceful design.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Laboratory Evaluation of Renal Disease in Childhood

Cited by 3 publications

References 192 publications

Idiopathic Urinary Bladder Perforation in Early Childhood

Idiopathic Urinary Bladder Perforation in Early Childhood

Normative values of renin and aldosterone in clinically stable preterm neonates

Recent advancements in urea biosensors for biomedical applications

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