Laboratory Evaluation of a Quaternary Ammonium Compound-Based Antimicrobial Coating Used in Public Transport during the COVID-19 Pandemic

Aranega-Bou, Paz; Brown, Natalie; Stigling, Abigail; D'Costa, Wilhemina; Verlander, Neville Q.; Pottage, Thomas; Bennett, Allan; Moore, Ginny

doi:10.1128/aem.01744-22

Cited by 5 publications

(3 citation statements)

References 31 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While samples were taken before daily terminal cleaning, high bacterial levels demonstrate the ease with which passengers contaminate the environment. We previously showed that when Zoono was used to coat a range of materials relevant to public transport, the deposition of organic debris severely reduced its virucidal efficacy against ɸ6 (a surrogate for SARS-CoV-2) (Aranega-Bou et al, 2023). As part of the same study, we found that Zonitise, when applied to stainless steel or polystyrene test surfaces, was ineffective against ɸ6 even in the absence of organic debris (previously unpublished data, supplementary table 2).…”

Section: Discussionmentioning

confidence: 99%

A 17-month longitudinal environmental sampling study carried out on public transport vehicles operating in England during the COVID-19 pandemic identified low levels of SARS-CoV-2 RNA contamination

Aranega-Bou,

Pottage,

Fenwick

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

AimsTo monitor severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) RNA contamination in vehicles operating in England during the pandemic, to better understand transmission risk of SARS-CoV-2 on public transport.Methods and ResultsWe collected 1,314 surface samples between December 2020 and April 2022 on trains and buses managed by five different transport operators. The presence of SARS-CoV-2 RNA was investigated through reverse transcription polymerase chain reaction (RT-PCR). SARS-CoV-2 RNA was found on 197 (15%) of the 1,314 surfaces sampled, including seat head rests, handholds, and air extract grilles, but the levels of RNA recovered on those samples (median value of 23.4, inter-quartile range: 14.3-35.4,Ngene copies per extraction) made the presence of infectious virus at the time of sampling extremely unlikely. However, detection rates varied over time with peaks broadly coinciding with times of high community transmission, suggesting that people infected with SARS-CoV-2 when travelling on public transport could create opportunities for transmission.ConclusionDuring the pandemic, and as in other public spaces, low levels of SARS-CoV-2 RNA were found on surfaces associated with public transport.Impact statementThe results of this study will inform modelling approaches and the implementation of mitigation strategies to minimise the risk of transmission of respiratory viruses in public transport.

show abstract

Section: Discussionmentioning

confidence: 99%

A 17-month longitudinal environmental sampling study carried out on public transport vehicles operating in England during the COVID-19 pandemic identified low levels of SARS-CoV-2 RNA contamination

Aranega-Bou,

Pottage,

Fenwick

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…The risk of transmission from a brief contact with a single contaminated surface is generally low, however, as individuals are in contact with multiple contaminated surfaces, the population density is high, the duration of a stay in an existing location increases, and the effectiveness of mitigation measures is poor (e.g. surface cleansing and handwashing), the risk of infection's transmission escalates [ 1 ]. Pathogen transmission is not limited to healthcare settings like hospitals or medical centres.…”

Section: Introductionmentioning

confidence: 99%

“…Pathogen transmission is not limited to healthcare settings like hospitals or medical centres. It can also occur in community spaces such as public transportation, where numerous individuals come into contact with various surfaces such as seats, doorknobs, railings, tables, and armrests [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

On the antimicrobial properties and endurance of eugenol and 2-phenylphenol functionalized sol-gel coatings

Suárez-Vega,

Berriozabal,

Perez de Iriarte

et al. 2024

Heliyon

View full text Add to dashboard Cite

Tunable Assembly of Photocatalytic Colloidal Coatings for Antibacterial Applications

Sofroniou,

Scacchi,

et al. 2024

ACS Appl. Polym. Mater.

View full text Add to dashboard Cite

In this study, evaporation-induced size segregation and interparticle interactions are harnessed to tune the microstructure of photocatalytic colloidal coatings containing TiO 2 nanoparticles and polymer particles. This enabled the fabrication of a library of five distinct microstructures: TiO 2 -on-top stratification, a thin top layer of polymer or TiO 2 , homogeneous films of raspberry particles, and a sandwich structure. The photocatalytic and antibacterial activities of the coatings were evaluated by testing the viability of Methicillin-resistant Staphylococcus aureus (MRSA) bacteria using the ISO-27447 protocol, showing a strong correlation with the microstructure. UVA irradiation for 4 h induces a reduction in MRSA viability in all coating systems, ranging from 0.6 to 1.1 log. Films with TiO 2enriched top surfaces exhibit better resistance to prolonged exposure to disinfection and bacterial testing. The remaining systems, nonetheless, present higher antibacterial activity because of a larger number of pores and coating defects that enhance light and water accessibility for the generation and transport of reactive oxygen species. This work establishes design rules for photocatalytic coatings based on the interplay between performance and film architecture, offering valuable insights for several applications, including antibacterial surfaces, self-cleaning/antifogging applications, and water purification.

show abstract

Laboratory Evaluation of a Quaternary Ammonium Compound-Based Antimicrobial Coating Used in Public Transport during the COVID-19 Pandemic

Cited by 5 publications

References 31 publications

A 17-month longitudinal environmental sampling study carried out on public transport vehicles operating in England during the COVID-19 pandemic identified low levels of SARS-CoV-2 RNA contamination

A 17-month longitudinal environmental sampling study carried out on public transport vehicles operating in England during the COVID-19 pandemic identified low levels of SARS-CoV-2 RNA contamination

On the antimicrobial properties and endurance of eugenol and 2-phenylphenol functionalized sol-gel coatings

Tunable Assembly of Photocatalytic Colloidal Coatings for Antibacterial Applications

Contact Info

Product

Resources

About