Laboratory diagnosis of iron-deficiency Anemia: An overview

Guyatt, Gordon; Oxman, Andrew D; Ali, Mahmoud; Willan, Andrew R.; McIlroy, William E.; Patterson, Christopher

doi:10.1007/bf02599160

Cited by 141 publications

(192 citation statements)

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“…In this study, iron deficiency was defined based on lab assay standards as serum ferritin <20 ug/L or a soluble transferrin receptor> 28 mg/L, the manufacturer's suggested cutoff, irrespective of ferritin level. Ferritin is known to reflect total body iron stores in states of health, but increases in response to inflammation (36). Measuring sTfR concentration can improve the diagnostic accuracy of iron deficiency, particularly in the setting of inflammation or chronic disease.…”

Section: Anemia and Iron Deficiencymentioning

confidence: 99%

Is Iron Deficiency in the Absence of Anemia Associated With Fatigue in Inflammatory Bowel Disease?

Goldenberg

Graff

Clara

et al. 2013

American Journal of Gastroenterology

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Section: Anemia and Iron Deficiencymentioning

confidence: 99%

Is Iron Deficiency in the Absence of Anemia Associated With Fatigue in Inflammatory Bowel Disease?

Goldenberg

Graff

Clara

et al. 2013

American Journal of Gastroenterology

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“…A review of 55 studies assessing the clinical utility of mean cellular volume, mean cellular hemoglobin, random distribution width, and erythrocyte protoporphyrin displayed area under the curves (AUCs) between 0.62 and 0.77 when compared to bone marrow iron content as the gold standard assay [2]. The AUC for transferrin saturation is also within this range [2,3]. In contrast, serum ferritin had an average AUC of 0.95 confirming that it is the best single test for assessment of body iron stores.…”

Section: Introductionmentioning

confidence: 99%

Reticulocyte hemoglobin content

2007

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Under normal conditions, reticulocytes are the youngest erythrocytes released from the bone marrow into circulating blood. They mature for 1–3 days within the bone marrow and circulate for 1–2 days before becoming mature erythrocytes. Measurement of cellular hemoglobin concentration has long been reported by automated hematology analyzers as one of the red blood cell indices. The reticulocyte hemoglobin content (CHr or Ret‐He) provides an indirect measure of the functional iron available for new red blood cell production over the previous 3–4 days. Measurement of reticulocyte hemoglobin content in peripheral blood samples is useful for diagnosis of iron deficiency in adults (Mast et al., Blood 2002;99:1489–1491) and children (Brugnara et al., JAMA 1999;281:2225–2230; Ullrich et al., JAMA 2005;294:924–930; Bakr and Sarette, Eur J Pediatr 2006;165:442–445). It provides an early measure of the response to iron therapy increasing within 2–4 days of the initiation of intravenous iron therapy (Brugnara et al., Blood 1994;83:3100–3101). Sequential measurements of reticulocyte hemoglobin content in patients with iron deficiency anemia provide a rapid means for assessing the erythropoietic response to iron replacement therapy (Brugnara et al., Blood 1994;83:3100–3101). It is also an early indicator or iron‐restricted erythropoiesis in patients receiving erythropoietin therapy (Fishbane et al., Kidney Int 1997;52:217–222; Fishbane et al., Kidney Int 2001;60:2406–2411; Mittman et al., Am J Kidney Dis 1997;30:912–922; Tsuchiya et al., Clin Nephrol 2003;59:115–123; Chuang et al., Nephrol Dial Transplant 2003;18:370–377). Thus, reticulocyte hemoglobin content is a recent addition to an expanding list of biomarkers that can be used to differentiate iron deficiency from other causes of anemia. Am. J. Hematol., 2008. © 2007 Wiley‐Liss, Inc.

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“…In this study, the patient had a decrease in ferritin and control group did not have any inflammatory disease, so the effect of inflammation on serum ferritin levels was removed. Many studies [3,5,7,10] have shown the relationship between H. pylori infection and iron deficiency anemia. Mozon et al in the study had results similar to our results, in this study patients with H.pylori infection and IDA were treated for H. pylori and in patients treated significantly improve IDA were observed, therefore concluded that the infection can cause IDA that was consistent with our results [11].…”

Section: Discussionmentioning

confidence: 99%

“…Most significant laboratory finding including decreased MCV (mean cell volume), MCHC (mean cell hemoglobin concentration) and levels of serum ferritin and increased TIBC (total iron binding capacity). Peripheral blood of patients is hypochromic microcytic RBC (red blood cell) [5]. Helicobacter pylori infection is causes chronic gastritis, peptic ulcer and gastric carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Serum Ferritin, TIBC Level and Helicobacter pylori Infection

Tari

Shamsi

Rahimi

et al. 2016

Zahedan J Res Med Sci

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Background: In iron deficiency anemia (IDA), serum ferritin level is decreased and total iron binding capacity (TIBC) is increased Objectives: In this study the relationship between H. pylori infection and iron deficiency anemia were studied. Methods: This research was a cross-sectional study. TIBC and ferritin levels were measured in 133 patients, suspected to H. pylori infection, then serum levels of IgM and IgG antibody against H. pylori infection were measured Results: From 133 patients, 97 were females (72.93%) and 36 males (28.07%), 36 of them (23 women and 13 men) have a TIBC levels more than 400 ug/dL and ferritin levels were less than 12ng/dL. Twenty patients had IgG antibodies and 5 patients had IgM against H. pylori. Conclusions:The results show the association between H. pylori infection and increased levels of TIBC and decreased serum ferritin.

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Laboratory diagnosis of iron-deficiency Anemia: An overview

Cited by 141 publications

References 0 publications

Is Iron Deficiency in the Absence of Anemia Associated With Fatigue in Inflammatory Bowel Disease?

Is Iron Deficiency in the Absence of Anemia Associated With Fatigue in Inflammatory Bowel Disease?

Reticulocyte hemoglobin content

Relationship Between Serum Ferritin, TIBC Level and Helicobacter pylori Infection

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