Laboratory biomarkers of COVID-19 disease severity and outcome: Findings from a developing country

Leulseged, Tigist Workneh; Hassen, Ishmael S.; Ayele, Birhanu; Tsegay, Yakob Gebregziabher; Abebe, Daniel S.; Edo, Mesay G.; Maru, Endalkachew H.; Zewde, Wuletaw C.; Naylor, Lydia K.; Semane, Dejene F.; Dresse, Menayit T.; Tezera, Bereket B.

doi:10.1371/journal.pone.0246087

Cited by 44 publications

(55 citation statements)

References 27 publications

(45 reference statements)

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“…The various other parameters were, however, almost similar in both groups. This is in conjunction with most other studies, thus signifying the role of these laboratory parameters in determining the severity of COVID-19 disease and the high rates of mortality [8,13,[17][18]. C-reactive protein and serum ferritin were elevated among non-survivors thus stressing the role of the inflammatory cytokine storm in the disease severity and poor prognosis [13].…”

Section: Discussionsupporting

confidence: 67%

Epidemiology and Risk Factors of COVID-19-Related Mortality

Roy¹,

Gupta²,

Tomar³

et al. 2021

Cureus

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IntroductionDuring the coronavirus disease 2019 (COVID-19) pandemic in India, several characteristics of hospitalized COVID-19 patients, based on demographics, mortality predictors, and presence of comorbidities, were found to be associated with poor outcomes. The objective of this study was to identify such epidemiological and clinical characteristics among the patients admitted at a tertiary-care center in India that may have predisposed them to COVID-19-related mortality.

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Section: Discussionsupporting

confidence: 67%

Epidemiology and Risk Factors of COVID-19-Related Mortality

Roy¹,

Gupta²,

Tomar³

et al. 2021

Cureus

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“…Several previous studies have reported that hypokalemia was not associated with the risk of transfer to intensive care and death, as in our study 16,17 . Contrary to these results, hypokalemia was associated with disease severity in 429 patients, and hypokalemia was associated with disease severity and the need for mechanical ventilation in 306 patients 15,22 . According to these studies, this relationship may be due to negative effects such as hypokalemia-induced myocardial dysfunction, ventricular arrhythmia, and respiratory muscle dysfunction 15 .…”

Section: Discussioncontrasting

confidence: 66%

Effects of hypokalemia on clinical outcomes in hospitalized patients with Covid-19 pneumonia

Kaya

Paydaş

Kuzu

et al. 2021

Cukurova Medical Journal

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Purpose: We investigated the effects of hypokalemia on clinical outcomes in hospitalized patients with Covid-19 pneumonia. Materials and Methods: In this single-center retrospective study, we recorded characteristics of hospitalized covid-19 pneumonia patients and laboratory test results on the first hospital day. Duration of hospitalization, requiring intensive care including mechanical ventilation and survival, were determined. Results: Our study included 185 patients and of them 111 male (60% male) patients with mean age of 64 ± 14.5 (23-90). Patients were grouped as hypokalemic (16.8%) and normokalemic patients (83.2%). The number of diabetic patients was higher in the normokalemic group. Serum total protein and albumin levels were lower in hypokalemic group, while alkaline phosphatase, gamma-glutamyl transpeptidase, total bilirubin, direct bilirubin, blood pH and bicarbonate level were higher. In multiple logistic regression analyses, alkalosis increased risk of hypokalemia 5.73 times. Duration of hospitalization, requirement of intensive care and hospital mortality were similar in hypokalemia and normokalemia patients. Conclusion: In patients with Covid-19 pneumonia, hypokalemia has been found to be quite common as high as 16.8% at the first presentation. Hypokalemia was related to metabolic alkalosis but unrelated to the duration of hospitalization, requirement of intensive care including mechanical ventilation and hospital mortality.

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“…Comorbidities were reviewed from the clinical records and dummy encoded (0/1) for each of the five following items: 1. history of arterial hypertension or current anti-hypertensive medication, 2. history of diabetes or current antidiabetic medication, 3. prior cardiovascular event (myocardial infarction or revascularization procedure, stroke or transient ischemic attack, or diagnosis of peripheral arterial disease), 4. history of hyperlipidemia or lipid-lowering agents in current medication, 5. active smoking habit. Further, commonly reported laboratory values for high-risk COVID-19 were noted from the clinical records (creatinine, C-reactive protein, leucocyte as well as thrombocyte counts, relative lymphocyte count, d-dimer, and lactate dehydrogenase levels) [16][17][18][19]. Laboratory tests were performed on the day of the CT scan (+/-1 day).…”

Section: Clinical Follow-up Comorbidity and Laboratory Testsmentioning

confidence: 99%

Coronary artery calcification on low-dose chest CT is an early predictor of severe progression of COVID-19—A multi-center, multi-vendor study

et al. 2021

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Purpose Cardiovascular comorbidity anticipates severe progression of COVID-19 and becomes evident by coronary artery calcification (CAC) on low-dose chest computed tomography (LDCT). The purpose of this study was to predict a patient’s obligation of intensive care treatment by evaluating the coronary calcium burden on the initial diagnostic LDCT. Methods Eighty-nine consecutive patients with parallel LDCT and positive RT-PCR for SARS-CoV-2 were included from three centers. The primary endpoint was admission to ICU, tracheal intubation, or death in the 22-day follow-up period. CAC burden was represented by the Agatston score. Multivariate logistic regression was modeled for prediction of the primary endpoint by the independent variables “Agatston score > 0”, as well as the CT lung involvement score, patient sex, age, clinical predictors of severe COVID-19 progression (history of hypertension, diabetes, prior cardiovascular event, active smoking, or hyperlipidemia), and laboratory parameters (creatinine, C-reactive protein, leucocyte, as well as thrombocyte counts, relative lymphocyte count, d-dimer, and lactate dehydrogenase levels). Results After excluding multicollinearity, “Agatston score >0” was an independent regressor within multivariate analysis for prediction of the primary endpoint (p<0.01). Further independent regressors were creatinine (p = 0.02) and leucocyte count (p = 0.04). The Agatston score was significantly higher for COVID-19 cases which completed the primary endpoint (64.2 [interquartile range 1.7–409.4] vs. 0 [interquartile range 0–0]). Conclusion CAC scoring on LDCT might help to predict future obligation of intensive care treatment at the day of patient admission to the hospital.

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Laboratory biomarkers of COVID-19 disease severity and outcome: Findings from a developing country

Cited by 44 publications

References 27 publications

Epidemiology and Risk Factors of COVID-19-Related Mortality

Epidemiology and Risk Factors of COVID-19-Related Mortality

Effects of hypokalemia on clinical outcomes in hospitalized patients with Covid-19 pneumonia

Coronary artery calcification on low-dose chest CT is an early predictor of severe progression of COVID-19—A multi-center, multi-vendor study

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