Laboratory biomarkers of an effective antitumor immune response. Clinical significance.

Малкова, Анна; Sharoyko, Vladimir V.; Zhukova, Natalia V.; Gubal, Anna; Orlova, Rashida

doi:10.1016/j.ctarc.2021.100489

Cited by 2 publications

(3 citation statements)

References 116 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The importance of lymphocytes has been highlighted in several studies in which increasing infiltration of tumors with lymphocytes has been associated with better response to cytotoxic treatment and prognosis in cancer patients 20 …”

Section: Discussionmentioning

confidence: 99%

“…19 The importance of lymphocytes has been highlighted in several studies in which increasing infiltration of tumors with lymphocytes has been associated with better response to cytotoxic treatment and prognosis in cancer patients. 20 Only a few studies have been published investigating inflamma- F I G U R E 1 Three years disease-free survival (DFS) in patients of high-risk group (HR) and low-risk group (LR).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A prognostic score from a multicentric retrospective analysis of patients affected by sarcoma with metachronous lung metastases undergoing metastasectomy

Gallina

Melis

Bertolaccini

et al. 2023

Journal of Surgical Oncology

View full text Add to dashboard Cite

Background Despite the lack of evidence‐based on prospective randomized studies, surgery has become the cornerstone of the treatment in patients with pulmonary oligometastatic sarcomas. Our study aimed to construct a composite prognostic score for metachronous oligometastatic sarcoma patients. Methods A retrospective analysis was performed on data patients who underwent radical surgery for metachronous metastases in six research institutes from January 2010 to December 2018. The log‐hazard ratio (HR) obtained from the Cox model was used to derive weighting factors for a continuous prognostic index designed to identify differential outcome risks. Results A total of 251 patients were enrolled in the study. In the multivariate analysis, a longer disease‐free interval (DFI) and a lower neutrophil‐to‐lymphocytes ratio (NLR) were predictive of a better overall survival (OS) and disease‐free survival (DFS). A prognostic score was developed based on DFI and NLR data, identifying 2 risk class groups for DFS (3‐years DFS 20.2% for the high‐risk group [HRG]and 46.4% for the low‐risk group [LRG] [<0.0001]) and 3 risk groups for OS (3 years OS 53.9% for the HRG vs. 76.9% for the intermediate‐risk group and 100% of the LRG (p < 0.0001)). Conclusion The proposed prognostic score effectively predicts outcomes for patients with lung metachronous oligo‐metastases from the surgically treated sarcoma.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

A prognostic score from a multicentric retrospective analysis of patients affected by sarcoma with metachronous lung metastases undergoing metastasectomy

Gallina

Melis

Bertolaccini

et al. 2023

Journal of Surgical Oncology

View full text Add to dashboard Cite

show abstract

“…In addition, in this study, an increase in the expression of CCL3 and VEGF genes was observed in F. nucleatum-positive samples than in F. nucleatum-negative samples. Both of these genes have been implicated in cancer progression and angiogenesis (23)(24)(25). Also known as macrophage inflammatory protein-1 alpha, CCL3 is a chemokine that recruits immune cells to the site of inflammation and contributes to the progression of various cancers (26,27).…”

mentioning

confidence: 99%

Fusobacterium nucleatum-Mediated Alteration in Expression of VEGF and CCL3 Genes and KRAS Mutation in Colorectal Cancer Patients

Taher,

Kamel

2023

Jundishapur J Microbiol

View full text Add to dashboard Cite

Background: Colorectal cancer (CRC) is the third most common cancer worldwide, and its development is influenced by genetic and environmental factors, including the gut microbiota. Recent studies have reported an association between Fusobacterium nucleatum abundance and CRC. Objectives: This study aimed to investigate the abundance of F. nucleatum in CRC and polyp patients and its association with the expression of Chemokine ligand -3(CCL3), Vascular endothelial growth factor (VEGF), and Nuclear factor-kappa B (NF-KB11) genes and the presence of deoxyribonucleic acid (DNA) mutations and polymorphisms in the Kirsten rat sarcoma viral oncogene homolog (KRAS) gene. Methods: A total of 80 biopsy samples were collected from CRC, polyp, and colitis patients. Moreover, F. nucleatum abundance was measured by quantitative polymerase chain reaction (qPCR). The expression of CCL3, VEGF, and NF-KB11 genes was measured by reverse transcription polymerase chain reaction (RT-PCR). Additionally, KRAS gene mutations and polymorphisms were detected by the Mutation Surveyor software (V5.1.2). Results: The results showed that F. nucleatum abundance was significantly higher in CRC and polyp patients than in colitis patients (P < 0.05). The expression of CCL3 and VEGF genes was also significantly higher in F. nucleatum-positive samples (P < 0.05). However, NF-KB11 gene expression was non-significant. F. nucleatum-positive biopsy samples had a higher frequency of KRAS gene mutations and polymorphisms than F. nucleatum-negative CRC patients (odds ratio = 3). Most of the mutations observed in the positive samples were (6144A>AT,31E>E) at exon 2 of the KRAS gene. Conclusions: The study findings suggest that F. nucleatum might play a role in CRC and polyp development and contribute to KRAS gene mutations. Therefore, targeting F. nucleatum in the gut microbiota could be a potential therapeutic strategy for preventing CRC and polyp development.

show abstract

Laboratory biomarkers of an effective antitumor immune response. Clinical significance.

Cited by 2 publications

References 116 publications

A prognostic score from a multicentric retrospective analysis of patients affected by sarcoma with metachronous lung metastases undergoing metastasectomy

A prognostic score from a multicentric retrospective analysis of patients affected by sarcoma with metachronous lung metastases undergoing metastasectomy

Fusobacterium nucleatum-Mediated Alteration in Expression of VEGF and CCL3 Genes and KRAS Mutation in Colorectal Cancer Patients

Contact Info

Product

Resources

About