Laboratory Biomarkers Associated with Severity and Mortality of COVID-19

Allarakia, Basmah M Azad; Gattan, Hattan S.; Al-ahmadi, Bassam M.; Abdeen, Rawan; Bazaid, Mohammed B.; Shater, Abdullah F.; Jalal, Mohammed M.; Saeedi, Nizar H.; Mohammedsaleh, Zuhair M.; Altayar, Malik A.; Alreshidi, Maha; Bazaid, Abdulrahman S.

doi:10.7754/clin.lab.2021.210411

Cited by 2 publications

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“…The study by Keane Lan et al indicated an association between primary BUN and the incidence of cardiovascular disease in women. Higher BUN was observed to be related to an increased risk of atrial fibrillation in women and kidney disease in both groups, while no association was found between BUN and heart disease in men (19).…”

Section: Discussionmentioning

confidence: 79%

Investigating Laboratory Biochemical Factors in Different Types of Patients With Cardiovascular Diseases

Tarashoki

Mezerji

Zahedi³

et al. 2022

Dis Diagn

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Background: Due to the destructive effect of cardiovascular disease on vital organs, the study of laboratory biochemical factors in the most common heart diseases is essential to accelerate the treatment of cardiovascular patients. Materials and Methods: This study was cross-sectional and analytical. By referring to the hospital information system of educational hospitals of the Abadan University of Medical Sciences, the necessary information of 565 patients with cardiovascular diseases (e.g., demographic information and laboratory diagnostic markers) from March 21, 2019, to March 19, 2020, was extracted through the hospital information system and completed checklist. Data analysis was performed using SPSS software version 22. Results: In this study, fasting blood sugar (FBS), international normalized ratio (INR), erythrocyte sedimentation rate (ESR), Serum glutamate pyruvate transaminase (SGPT), serum glutamate oxalate transaminase (SGOT), creatinine, blood urea nitrogen (BUN), total bilirubin, creatine kinase (CK)- MB, and prothrombin time (PT) were higher than normal in patients with cardiovascular diseases. SGOT was significantly different between age groups (P=0.006), and the highest value was observed in the age group over 75 years. Moreover, FBS was significantly different between the male and female groups (P=0.002). Conclusion: FBS and some diagnostic markers such as renal markers, liver, coagulation, and inflammatory markers are abnormal in patients with cardiovascular diseases.

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Section: Discussionmentioning

confidence: 79%

Investigating Laboratory Biochemical Factors in Different Types of Patients With Cardiovascular Diseases

Tarashoki

Mezerji

Zahedi³

et al. 2022

Dis Diagn

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“…There was a significant reduction in lymphocyte, monocyte, eosinophil, and platelet counts as well as hemoglobin levels in severe cases compared with mild and moderate cases [ 33 ]. The study also highlighted the higher neutrophil count, ALT, AST, creatinine, and BUN in COVID-19 patients with severe symptoms and possible admission to the ICU [ 3 , 34 ]. Other biomarkers, such as LDH, PT, and D-dimer, were also associated with the severity of the disease and admission to the ICU [ 33 – 35 ].…”

Section: Discussionmentioning

confidence: 99%

Predicting Intensive Care Unit Admission for COVID-19 Patients from Laboratory Results

Allarakia¹,

Gattan

Abdeen

et al. 2022

Disease Markers

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Trends in routine laboratory tests, such as high white blood cell and low platelet counts, correlate with COVID-19-related intensive care unit (ICU) admissions. Other related biomarkers include elevated troponin, alanine aminotransferase, and aspartate transaminase levels (liver function tests). To this end, the aim of this study was to investigate the effect of changes in laboratory test parameters on ward-based and ICU COVID-19 patients. A total of 280 COVID-19 patients were included in the study and were divided based on admission status into ICU (37) or ward (243) patients. ICU admission correlated significantly with higher levels of several tested parameters, including lactate dehydrogenase, creatinine, D-dimer, creatine kinase, white blood cell count, and neutrophil count. In conclusion, routine laboratory tests offer an indication of which COVID-19 patients are most likely to be admitted to the ICU. These associations can assist healthcare providers in addressing the needs of patients who are at risk of COVID-19 complications.

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Laboratory Biomarkers Associated with Severity and Mortality of COVID-19

Cited by 2 publications

References 0 publications

Investigating Laboratory Biochemical Factors in Different Types of Patients With Cardiovascular Diseases

Investigating Laboratory Biochemical Factors in Different Types of Patients With Cardiovascular Diseases

Predicting Intensive Care Unit Admission for COVID-19 Patients from Laboratory Results

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