Laboratory-based surveillance of hospital-acquired respiratory virus infection in a tertiary care hospital

Choi, Hye-Suk; Kim, Mina; Sung, Heungsup; Park, Hee-Youn; Kwak, Sun Hee; Lim, Young‐Ju; Hong, Min-Jee; Kim, Sun-Kyung; Park, So‐Yeon; Kim, Hyeon-Jeong; Kim, Kyu-Ri; Choi, Hyung Soon; Jeong, Jae Sim; Choi, Sang‐Ho

doi:10.1016/j.ajic.2017.01.009

Cited by 14 publications

(13 citation statements)

References 10 publications

(8 reference statements)

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“…Finally, respiratory viruses other than influenza comprised 80% of cases of VAHAP and one half of all cases of nosocomial pneumonia. This coincides with the findings of previous studies, in which the main viruses identified in patients with HAP were rhinovirus, respiratory syncytial virus, parainfluenza and coronavirus (21,23,(27)(28)(29). This highlights the relevance of infection control measures in preventing the spread of respiratory viruses from patients, caregivers and healthcare personnel, focusing not only on individuals with influenza-like illness, but also those with common colds or other respiratory symptoms.…”

Section: Discussionsupporting

confidence: 90%

Healthcare-Associated Pneumonia: Don't Forget About Respiratory Viruses!

et al. 2019

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Introduction: Healthcare-associated infections are an important cause of morbidity and mortality, are among the most common adverse events in healthcare, and of them, pneumonia is the most commonly reported. Our objective was to evaluate the incidence and clinical outcome of respiratory viruses in hospital-acquired pneumonia (HAP). Methods: This was a prospective cohort study, include patients aged between 0 and 18 who fulfilled Centers for Diseases Control and Prevention (CDC) criteria for HAP. Demographic and clinical data were obtained, and a nasopharyngeal swab specimen was taken for the detection of respiratory viruses. All included patients were monitored until discharge to collect data on the need for mechanical ventilation, intensive care unit (ICU) admission, and mortality. All-cause 30-day mortality was also ascertained. Results: Four thousand three hundred twenty-seven patients were followed for 42,658 patient-days and 5,150 ventilator-days. Eighty-eight patients (2.03%) met the CDC criteria for HAP, 63 patients were included, and clinical and epidemiological characteristics showed no statistically significant differences between patients with virus associated healthcare-associated pneumonia (VAHAP) and those with non-viral healthcare-associated pneumonia (NVHAP). At least one respiratory virus was detected in 65% [95% CI (53–77)] of episodes of HAP, with a single viral pathogen observed in 53.9% and coinfection with 2 viruses in 11.1% of cases. The outcome in terms of ICU admission, mechanical ventilation and the 30-day mortality did not show a significant difference between groups. Conclusions: In two-thirds of the patients a respiratory virus was identified. There was no difference in mortality or the rest of the clinical outcome variables. About half of the patients required mechanical ventilation and 10% died, which emphasizes the importance of considering these pathogens in nosocomial infections, since their identification can influence the decrease in hospital costs and be taken into account in infection control policies.

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Section: Discussionsupporting

confidence: 90%

Healthcare-Associated Pneumonia: Don't Forget About Respiratory Viruses!

et al. 2019

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“…In this work, it was observed that the incidence of hospital-acquired SARS-CoV-2 infection within a single large health system during a period of universal admission testing was relatively low. Other reports have found annualized hospital-associated respiratory viral infection rates to be ~4.9 (95%, 4.7–5.2) cases per 10 000 patient-days [ 9 ], consistent with the upper range of our estimate for SARS-CoV-2. As health systems and public health authorities communicate the need to avoid foregoing necessary clinical care, transparent enumeration of the risks of SARS-CoV-2 transmission within health care settings will be essential.…”

Section: Discussionsupporting

confidence: 91%

Incidence of Health Care–Associated COVID-19 During Universal Testing of Medical and Surgical Admissions in a Large US Health System

Long

O’Reilly-Shah

Rustagi

et al. 2020

Open Forum Infectious Diseases

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“…In a study conducted in the U.S., RSV infection comprised 8.3% of acute respiratory illnesses among the elderly; this proportion was 4% in a French study 13 , 14 . In Korean studies, laboratory-confirmed RSV infection accounted for 2.8% of all respiratory viral infections and 12.7% of hospitalizations on account of respiratory viral infection 15 , 16 . However, the percentage of RSV among all respiratory illnesses including bacterial infection in Korean adults had not been reported.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and disease burden of respiratory syncytial virus infection among hospitalized adults

Yoon

Noh

Choi

et al. 2020

Sci Rep

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the disease burden of respiratory syncytial virus (RSV) infection in the adult population has not been well characterized compared to children. investigation of the clinical characteristics and disease burden of adult RSV infection would help to establish public health policy and a future vaccine strategy. We retrospectively collected medical records of hospitalized adult patients who were diagnosed with RSV infection from January 2012 to December 2015 from three tertiary hospitals. Baseline characteristics, clinical outcomes and economic charge during hospitalization were compared by age groups (19-49 years, 50-64 years, and ≥ 65 years) using Chi-square test. The odds of risk factors of RSV pneumonia were calculated using binary logistic regression. A total of 204 patients from three hospitals were enrolled. Patients who older than 65 years were 132 (64.7%). 118 (57.8%) patients had clinically confirmed pneumonia and 22 (10.8%) died in a hospital. The median medical cost of RSV pneumonia was 2,855.26 USD (interquartile range, 1,561.85-5,379.55) per each admission. Solid cancer (adjusted OR, 3.85; 95% CI, 1.65-9.02, p = 0.002) and hematologic malignancy (all patients had pneumonia) were shown to be risk factors for RSV pneumonia. RSV infection in South Korea seemed to have a significant burden among adults as pneumonia, care in the intensive care unit and mortality. Nationwide awareness and further effort to recognize the current burden, prepare specific treatment, and prevent adult RSV infection would be necessary. Respiratory syncytial virus (RSV) belongs to the family of Paramyxoviridae and is the most important cause of lower respiratory tract infection in infants and young children. The virus causes common cold, bronchiolitis and pneumonia which are spread by close contact and large droplets. However, the clinical impact of RSV infection in adult populations had been underestimated until outbreaks in hospitals and healthcare facilities were identified. The infection may induce serious outcome especially in the elderly, patients with chronic cardiopulmonary disease and immunocompromised individuals 1. Also, the disease burden of RSV is not negligible compared to influenza among adults at high risk or the elderly 2,3. In the United States, annually 2-10% of community-dwelling older adults are infected and approximately 11,000 persons die due to the illness 4. In South Korea, RSV was detected in 1.1% of all adult respiratory infections and shows similar seasonal occurrence during childhood 5,6. Recently, the Strategic Advisory Group of Experts of the World Health Organization presented an issue of RSV vaccine production in April 2016, and stated that the elderly, pregnant women and immunocompromised patients would be the target populations of the RSV vaccine. Therefore, a precise investigation of the epidemiology and disease burden of adult RSV infection is key to establishing an accurate vaccine strategy. Furthermore, the increasing elderly population with debilitated host immune response and underlying comorb...

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Laboratory-based surveillance of hospital-acquired respiratory virus infection in a tertiary care hospital

Cited by 14 publications

References 10 publications

Healthcare-Associated Pneumonia: Don't Forget About Respiratory Viruses!

Healthcare-Associated Pneumonia: Don't Forget About Respiratory Viruses!

Incidence of Health Care–Associated COVID-19 During Universal Testing of Medical and Surgical Admissions in a Large US Health System

Clinical characteristics and disease burden of respiratory syncytial virus infection among hospitalized adults

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