Laboratory assessment of environmental impact of phthalazine

Lande, Stig; Elnabarawy, M. T.; Reiner, E. A.; Welter, A. N.; Robideau, R. R.

doi:10.1007/bf01606683

Bull. Environ. Contam. Toxicol.

1987

DOI: 10.1007/bf01606683

|View full text |Cite

Laboratory assessment of environmental impact of phthalazine

Stig Lande¹,

M. T. Elnabarawy²,

E. A. Reiner³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

1999

2011

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

(1 citation statement)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One azaarene that has pharmacological relevance is phthalazine (= 2,3-diazanaphthalene), which is produced during the in vivo metabolism of the antihypertensive drug hydralazine (Lesser et al 1974). It is also found in certain specialized paper products (Lande et al 1987).…”

mentioning

confidence: 94%

Biotransformation of Phthalazine by Fusarium moniliforme and Cunninghamela elegans

Sutherland

Freeman²,

Williams³

et al. 1999

Mycologia

View full text Add to dashboard Cite

Fusarium moniliforme and Cunninghamella elegans were grown in fluid Sabouraud medium at 28 C. They were dosed with 6.2 mM phthalazine and then incubated for 3 d with shaking at 125 rpm. After extraction with ethyl acetate, the metabolites were purified by HPLC and identified by the UV/visible, mass, and NMR spectra. The results show that F moniliforme oxidized about 42% of the phthalazine to 1(2H)-phthalazinone (= 1-hydroxyphthalazine) and that C. elegans oxidized about 6% of the phthalazine to a novel metabolite, phthalazine N-oxide (= phthalazine 2-oxide).

show abstract

mentioning

confidence: 94%

Biotransformation of Phthalazine by Fusarium moniliforme and Cunninghamela elegans

Sutherland

Freeman²,

Williams³

et al. 1999

Mycologia

View full text Add to dashboard Cite

show abstract

Characterization of organic particulates present in milk factory process waters used for reuse along with aerobically digested effluent wastewater

Verheyen

Cruickshank

Wild³

et al. 2011

Bioresource Technology

View full text Add to dashboard Cite

Biotransformation of phthalazine byFusarium moniliformeandCunninghamella elegans

et al. 1999

View full text Add to dashboard Cite

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Laboratory assessment of environmental impact of phthalazine

Cited by 3 publications

References 5 publications

Biotransformation of Phthalazine by Fusarium moniliforme and Cunninghamela elegans

Biotransformation of Phthalazine by Fusarium moniliforme and Cunninghamela elegans

Characterization of organic particulates present in milk factory process waters used for reuse along with aerobically digested effluent wastewater

Biotransformation of phthalazine byFusarium moniliformeandCunninghamella elegans

Contact Info

Product

Resources

About