Laboratory approach for vaccine‐induced thrombotic thrombocytopenia diagnosis in the Netherlands
Romy T. Meier,
Leendert Porcelijn,
Suzanne Hofstede‐van Egmond
et al.
Abstract:Background and ObjectivesVaccine‐induced thrombotic thrombocytopenia (VITT) is a rare adverse effect characterized by thrombocytopenia and thrombosis occurring after COVID‐19 vaccination. VITT pathophysiology is not fully unravelled but shows similarities to heparin‐induced thrombocytopenia (HIT). HIT is characterized by the presence of antibodies against platelet factor 4 (PF4)/heparin complex, which can activate platelets in an FcγRIIa‐dependent manner, whereas IgG‐antibodies directed against PF4 play an imp… Show more
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