Laboratorial Diagnosis of Syphilis

Sato, Noriharu

doi:10.5772/39126

Cited by 1 publication

(1 citation statement)

References 73 publications

(83 reference statements)

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“…Non-Treponemal Test such as Venereal Diseases Research Laboratory test (VDRL) used for screening and monitoring therapy. Treponemal test such as the Treponemal Pallidum Haemagglutination Assay Test (TPHA), used as confirmed test for syphilis because it has a higher sensitivity and specificity, it can detect antibodies in small amounts, and their appearance will last for a lifetime, but this test cannot be used as therapeutic monitoring [13], [14].…”

Section: Discussionmentioning

confidence: 99%

Neuroretinitis Syphilis in Human Immunodeficiency Virus-Infected Patient

Triningrat¹,

Budi²,

Juliari³

et al. 2019

Open Access Maced J Med Sci

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BACKGROUND: In HIV-infected patient who accompanied by syphilis often difficult to diagnose and difficult to treat. The aim is to diagnostics understanding and to optimise the management and response therapy in patients with neuroretinitis syphilis in HIV-infected patients. CASE PRESENTATION: A 53-years old, bisexual, male patient whose initial presentation was a blurry vision on the left eye. History of a painless genital lesion, HIV infection (+) on ARV therapy. The visual acuity of hand movement (HM), RAPD (+), with vitreous opacities and optic disc swelling. The OCT RNFL showed neural layer thickening in all areas. VEP showed increased P100 latency, normal head and orbital CT scan. High VDRL and TPHA titer. Lumbar puncture examination showed non-reactive VDRL. Treated with topical prednisolone eye drops, oral neurotropic vitamin, and intramuscular injection of Benzathine Penicillin G. Diagnosed with OS neuroretinitis et causa syphilis infection, HIV stage II on HAART. Follow up in 2 months, the visual acuity improved, and serology post-therapy VDRL was decreased. CONCLUSION: High accuracy is needed for screening signs and symptoms in syphilis patients because of the varied clinical manifestations. Ocular syphilis manifestation in HIV has a higher risk for neurologic complications and the risk of failing treatment with the standard regimen.

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Section: Discussionmentioning

confidence: 99%