Introduction: Normal physiologic childbirth program was implemented in mother-friendly hospitals of Iran after 2008. The aim of present study is to assess the effect of normal physiologic childbirth program in a mother-friendly hospital on duration of active phase and second stage of labor. Methods: This study was a clinical trial that was conducted at the Sina and Ommolbanin mother-friendly hospitals in Ahvaz, Mashhad, Iran, in 2016. The intervention group of 77 women was offered the childbirth preparation classes during pregnancy and normal physiologic childbirth program during labor and the control group of 77 women received routine care. Results: The results showed that after controlling the confounding factors, the active phase and second stage of labor were significantly shorter in the intervention group (p<0.001). Conclusion: Complete implementation of normal physiologic childbirth program can reduce the duration of labor.Keywords: natural childbirth, prenatal education, non-pharmacologic approaches, first stage of labor, labor duration, second stage of labor Makvandi et al. / Effect of normal physiologic childbirth program in mother-friendly hospitals on duration of labor 2 / 6