Labor induction with dinoprostone or oxytocine and postpartum disseminated intravascular coagulation: A hospital-based case-control study

Abajo, Francisco J. de; Meseguer, Carmen M.; Antiñolo, Guillermo; Rodrı́guez, Luis A. Garcı́a; Montero, Dolores; Castillo, J. Ruiz del; Torelló, Jaume

doi:10.1016/j.ajog.2004.03.021

Cited by 6 publications

(6 citation statements)

References 11 publications

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“…During the study period, we have not encountered any or similar problems with the use of oxytocin for labor induction. On the contrary, De Abajo et al, Roungsipragarn et al, and Kramer et al have reported that regardless the substance used, pharmacologic induction of labor is associated with an increased risk of postpartum DIC or AFE [1,2,5]. In their early report [2], Roungsipragarn et al have used oxytocin, after dinoprostone insertion for labor augmentation which resulted with AFE and maternal death, and they have commented that one has to be extra careful when both dinoprostone and oxytocin were used.…”

Section: Discussionmentioning

confidence: 96%

“…First, all confounding factors which may be in direct relation with AFE should be eliminated, than the pathophysiology of AFE related to PGE 2 should be resolved. However, the possible association between dinoprostone and AFE isn't a new fact and there are reports in the literature suggesting an association between dinoprostone used for labor induction and AFE [1][2][3][4].…”

Section: Discussionmentioning

confidence: 99%

“…They have reported a very similar clinical picture as seen in our cases; however, they preferred to use the term 'anaphylactoid syndrome of pregnancy' instead of AFE. In their excellent work, De Abajo et al evaluated the association between dinoprostone and postpartum intravascular coagulation [1]. However, whatever the diagnosis is, these reports exhibit a causal relationship between dinoprostone and above mentioned clinical picture.…”

Section: Discussionmentioning

confidence: 99%

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Is dinoprostone safe? A report of three maternal deaths

Dede

Kandemir

Yalvaç

et al. 2010

The Journal of Maternal-Fetal & Neonatal Medicine

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We report three maternal deaths which might be in possible association with the use of intravaginal dinoprostone for cervical ripening and induction of labor. All cases occurred at our institution between January 2006 and December 2007. Uterine atony and profuse bleeding followed by disseminated intravascular coagulation (DIC), characterized by severe hypofibrinogenemia developed shortly after delivery of the first two patients. The third patient developed respiratory symptoms in the active labor followed by hemodynamic changes manifested by tetanic uterine contractions and fetal heart rate decelerations. Cardiac arrest developed in all patients shortly after the occurrence of symptoms with no response to any medical intervention. The pharmacologic induction of labor with dinoprostone may be in association with increased risk of maternal death because of increased risk of postpartum DIC and amnionic fluid embolism. Further investigations seem to be needed.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Is dinoprostone safe? A report of three maternal deaths

Dede

Kandemir

Yalvaç

et al. 2010

The Journal of Maternal-Fetal & Neonatal Medicine

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“…For instance, foetal heartbeat and uterine contractions may be monitored by means of cardiotocogram. Medication may be administered to induce labour or reduce the risk of postpartum haemorrhage (de Abajo et al, 2004). Pain control may also be necessary during labour.…”

Section: Normal Child Delivery At Hospital: Medical Background and LImentioning

confidence: 99%

What can we learn from a cross-country comparison of the costs of child delivery?

Bellanger¹,

2008

Health Econ.

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SUMMARYThis study provides a comparative analysis of the costs of normal delivery in hospital in nine European countries using the data collected as part of the HealthBASKET project. The results show that both the level of input (medical labour) prices and the skill mix used for delivery are major determinants of total delivery costs. At the hospital level, there seems to be room for greater efficiency through specialisation and task shifting from doctors to midwives and nurses. More generally, the results of our study suggest that the costs of delivery in hospital are not independent of supplementary home care provided outside of hospitals. The cost information and analysis in this study may also be useful for developing healthcare-specific purchasing power parities (PPPs) that allow for healthcare expenditures to be compared across countries.

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“…There are many examples, including: (i) the increased risk of myocardial infarction associated with the use of highly active antiretroviral drugs; [41] (ii) the association of selective serotonin reuptake inhibitors (SSRIs) with bleeding disorders, in particular upper gastrointestinal bleeding; [42,43] and (iii) the association of dinoprostone (a prostaglandin E 2 drug) as a labour inducer with the increased risk of postpartum disseminated intravascular coagulation. [44] Spontaneous reports raised the signal in all of three examples but a rational decision was not possible until the completion of the epidemiological studies. In the first two examples the studies confirmed the hypothesis, but in the latter, the study showed that although there was an increased risk, this was not exclusive to dinoprostone and, therefore, the most probable hypothesis is that the labour induction itself was responsible.…”

Section: Risk Quantificationmentioning

confidence: 99%

Improving Pharmacovigilance Beyond Spontaneous Reporting

Abajo¹

2005

International Journal of Pharmaceutical Medicine

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About forty years ago pharmacovigilance started as a formal public health practice with the setting up of spontaneous reporting schemes. This can be recognised as the first generation of progress in this discipline. Since then, along with the consolidation of such programmes around the world, important new developments have taken place, reinforcing our ability to identify and characterise drug safety issues earlier and on more scientific grounds.The application of pharmacoepidemiological methods to drug safety evaluation has been crucial in this process, marking the second generation of progress. The conceptual evolution has been immense but there is still a lot of work to be done to transfer it into routine practice, in particular when the aim is to be proactive in anticipating and minimising drug safety issues. Patient risk management can be recognised as the third generation of progress and the new challenge for the first decades of the 21st century. Int J Pharm Med 2005; 19 (4): 209-218 1364-9027/05/0004-0209/$34.95/0 CURRENT OPINION

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Labor induction with dinoprostone or oxytocine and postpartum disseminated intravascular coagulation: A hospital-based case-control study

Cited by 6 publications

References 11 publications

Is dinoprostone safe? A report of three maternal deaths

Is dinoprostone safe? A report of three maternal deaths

What can we learn from a cross-country comparison of the costs of child delivery?

Improving Pharmacovigilance Beyond Spontaneous Reporting

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