Labetalol treatment of cocaine toxicity

Dusenberry, Sarah Jo; Hicks, Michael J.; Mariani, Peter J.

doi:10.1016/s0196-0644(87)80038-0

Cited by 47 publications

(4 citation statements)

References 2 publications

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“…In fact, in cocaine-induced hypertensive emergency, the use of ␤-adrenergic blockade can increase coronary vasoconstriction, fail to control heart rate, increase BP, and decrease survival. 150 -152 Interestingly, although labetalol is traditionally considered the ideal agent due to its ␣and ␤-adrenergic antagonism, experimental studies [153][154][155][156][157] do not support its use in this clinical setting. BP control is best achieved with nicardipine, fenoldopam, or verapamil in combination with a benzodiazepine.…”

Section: Sympathetic Crisesmentioning

confidence: 99%

Hypertensive Crises

Marik

Varon

2007

Chest

234

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Section: Sympathetic Crisesmentioning

confidence: 99%

Hypertensive Crises

Marik

Varon

2007

Chest

234

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“…In fact, in cocaine-induced hypertensive emergency, the use of beta-adrenergic blockade can increase coronary vasoconstriction, fail to control heart rate, increase blood pressure, and decrease survival (138)(139)(140). Interestingly, although labetalol is traditionally considered as the ideal agent because of its alpha-and beta-adrenergic antagonism, experimental studies do not support its use in this clinical setting (63,(141)(142)(143)(144). Blood pressure control is best achieved with nicardipine, fenoldopam, or verapamil in combination with a benzodiazepine (140, 145,146).…”

Section: Special Circumstances Regarding Managementmentioning

confidence: 99%

CRITICAL CARE ISSUES FOR THE NEPHROLOGIST: Current Diagnosis and Management of Hypertensive Emergency

Haas

Marik

2006

Seminars in Dialysis

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The appropriate and timely evaluation and treatment of patients with severely elevated blood pressure is essential to avoid serious adverse outcomes. Most importantly, the distinction between a hypertensive emergency (crisis) and urgency needs to be made. A sudden elevation in systolic (SBP) and/or diastolic blood pressure (DBP) that is associated with acute end organ damage (cardiovascular, cerebrovascular, or renal) is defined as a hypertensive crisis or emergency. In contrast, acute elevation in SBP and/or DBP not associated with evidence of end organ damage is defined as hypertensive urgency. In patients with a hypertensive emergency, blood pressure control should be attained as expeditiously as possible with parenteral medications to prevent ongoing and potentially permanent end organ damage. In contrast, with hypertensive urgency, blood pressure control can be achieved with the use of oral medications within 24-48 hours. This paper reviews the management of hypertensive emergencies.

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“…This is relevant to the treatment of arrhythmias as ␤-blockade alone may result in unopposed ␣-activity worsening hypertension and coronary vasoconstriction (Ramoska and Sachetti, 1985;Lange et al, 1990). Thus, an agent such as labetolol with ␣and ␤-activity should be used (Dusenberry et al, 1987;Gay and Loper, 1988). A selective ␤ 1 -agent such as esmolol may also be preferable in this instance (Pollan and Tadjziechy, 1989).…”

Section: Cocainementioning

confidence: 99%

The role of recreational drugs in trauma

Vidhani

Parr

2001

Trauma

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The association of trauma with illicit/recreational drugs is being increasingly recognized but is difficult to quantify. Significant amounts of these substances are readily available and may be taken alone, in combination with other drugs or with alcohol. The acute and chronic effects of these drugs result in numerous difficulties in management. Health-care workers involved in the treatment of trauma must have a high index of suspicion for the presence of drugs and a detailed knowledge of their effects. In this article we will review the scale of the problem, the common drugs abused and their effects, and we will discuss guidelines for management.

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Labetalol treatment of cocaine toxicity

Cited by 47 publications

References 2 publications

Hypertensive Crises

Hypertensive Crises

CRITICAL CARE ISSUES FOR THE NEPHROLOGIST: Current Diagnosis and Management of Hypertensive Emergency

The role of recreational drugs in trauma

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