1978
DOI: 10.1007/bf00611897
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Labetalol, a cross-over double blind controlled trial

Abstract: 20 patients (12 female) with moderately severe essential hypertension [blood pressure during placebo treatment 181 +/- 6 (systolic), 107 +/- 3 (diastolic)] completed a double-blind, cross-over dose-titrated comparison of labetalol and methyldopa. Both drugs reduced lying and standing arterial blood pressure to a similar extent, although only labetalol reduced heart rate. Compliance was high (greater than 95%) with both drugs, and the incidence of subjective adverse effects was similar.

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Cited by 10 publications
(4 citation statements)
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“…No serious toxic effects were noted. An isolated positive ANF is worrying, but of doubtful clinical significance, and has been reported before with several fl-adrenoceptor blockers as well as labetalol (Louis et al, 1978;Sanders et al, 1978). We found no evidence of a reduction in total white cell count, which has been reported previously (Sanders et al, Changes significantly different from zero = *P < 0.05, **P < 0.01.…”
Section: Discussionsupporting
confidence: 69%
See 1 more Smart Citation
“…No serious toxic effects were noted. An isolated positive ANF is worrying, but of doubtful clinical significance, and has been reported before with several fl-adrenoceptor blockers as well as labetalol (Louis et al, 1978;Sanders et al, 1978). We found no evidence of a reduction in total white cell count, which has been reported previously (Sanders et al, Changes significantly different from zero = *P < 0.05, **P < 0.01.…”
Section: Discussionsupporting
confidence: 69%
“…relatively few side-effects (Frick & Porsti, 1976;Sanders, Routledge, Rao, Gales, Davies & Rawlins, 1978;Pugsley, Nassim, Armstrong & Beilin, 1979). We have compared the side-effects of labetalol and propranolol in 24 patients with mild or moderate hypertension which had previously failed to respond to a thiazide diuretic alone.…”
Section: Introductionmentioning
confidence: 99%
“…It has seldom necessitated withdrawal of the drug (Brogden et al, 1978;Weidmann et al, 1978;Sanders et al, 1978;Pugsley et al, 1979;Dawson et al. 1979; Kane et al, 1979).…”
Section: Discussionmentioning
confidence: 99%
“…Labetalol is a combined ac-and ,B-adrenoceptor antagonist, and an effective antihypertensive drug (Prichard, Thompson, Boakes, & Joekes, 1975;Sanders, Routledge, Rao, Gales, Davies & Rawlins, 1978). Considerable variation in plasma labetalol concentrations is likely to occur between individuals after oral administration because of extensive firstpass metabolism of the drug (Richards, Maconochie, Bland, Hopkins, Woodings & Martin, 1977) and to investigate this further, the pharmacokinetics and effects of labetolol were studied both between and within individual hypertensive patients.…”
Section: Introductionmentioning
confidence: 99%