Labelling of biologically active molecules with a cyclohexadiene tricarbonyl iron unit

Selective Iron-Mediated C- and O-Addition of Phenolic Nucleophiles to a Cyclohexadiene Scaffold Using Renewable Precursors

“…We opted for the second of these strategies in the preparation of the initial cationic iron complex. Once formed, the complex can react with a wide range of nucleophiles, including alcohols, amines, amides, azide, hydride, carbamate, thiols, enolates and malonates, allyl silanes, electron rich aromatics and heterocycles, organocuprates, organolithium reagents, organozinc reagents, Grignard reagents, phosphines, phosphites, and halides …”

“…While iron carbonyl complexes of dienes are of interest in their own right, for instance as bioprobes, ,, the corresponding demetalated products are more likely to find a wider application scope. Our next goal was thus to demonstrate the demetalation of the addition products by oxidative removal of the iron carbonyl moiety.…”

Calculating the CO-factored force constants of tricarbonyl complexes with Cs symmetry

“…Since the synthesis of Ni (CO) 4 as the first metal carbonyl complex in 1890 [1], these complexes attracts the scientists' attention. They were synthesized for employing in chemistry such as initial substance of binuclear complexes [2], complex synthesis with photolysis [3], far-infrared studies in gas phase [4], excited state infrared spectrum analysis [5], labeling of the biologically active molecules [6]. Furthermore, DFT (Density Functional Theory) investigations [7e11] and polymerization of metal carbonyl complexes [12,13] take part in scientific literature recently.…”

Bioimaging in the Mid-Infrared Using an Organometallic Carbonyl Tag

“…They can thus potentially be useful as spectroscopic tags for imaging in living systems. Organometallic compounds have already been employed in applications (9,10) such as the labeling of peptides (11)(12)(13)(14)(15) and enzymes (16) and in immunoassays (17)(18)(19)(20)(21)(22)(23). However, their use as spectroscopic imaging agents in cells appears to have been unexplored, although related work on the localization of organometallic compounds inside cells using XRF (24), fluorescence (25), and AAS (26) has been carried out.…”