Labeling of ambiguous subvoxel fibre bundle configurations in high angular resolution diffusion MRI

Savadjiev, Peter; Campbell, Jennifer S. W.; Descoteaux, Maxime; Deriche, Rachid; Pike, G. Bruce; Siddiqi, Kaleem

doi:10.1016/j.neuroimage.2008.01.028

Cited by 65 publications

(59 citation statements)

References 28 publications

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“…We used a modified brute-force streamline tractography approach that uses the information on subvoxel crossing fibers obtained from the Q-Ball imaging reconstruction and which is an adaptation of our earlier approach Savadjiev et al, 2006Savadjiev et al, , 2008. The maxima of the diffusion ODF were considered to correspond to fiber directions.…”

Section: Methodsmentioning

confidence: 99%

“…With standard diffusion tensor imaging (DTI), the pdf is modeled using a 3D Gaussian distribution function and, therefore, is limited in situations when voxels present with partial volume effects such as when fibers cross. It is for this reason that we have acquired the data using a model free high angular resolution diffusion imaging (HARDI) approach, which can be used to detect multiple fiber orientations, given by multiple ODF maxima, in individual voxels, unlike DTI techniques (for review, see Campbell et al, 2006;Savadjiev et al, 2006Savadjiev et al, , 2008. The use of high angular resolution makes the detection of fibers that cross other large fiber pathways, such as the SLF III, more likely.…”

Section: Limitations Of Diffusion-weighted Datamentioning

confidence: 99%

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Dissociating the Human Language Pathways with High Angular Resolution Diffusion Fiber Tractography

Frey¹,

Campbell²,

Pike³

et al. 2008

J. Neurosci.

391

364

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The anatomical connectivity of ventrolateral frontal areas 44 and 45, which in the human brain constitute Broca's region, has been revisited on the basis of experimental anatomical tracer evidence in the nonhuman primate that the homologues of areas 44 and 45 have distinct bidirectional corticocortical connections. Here we show, using high angular resolution diffusion imaging in the living human brain, a dissociation between the specific projections from the pars opercularis (area 44) and the pars triangularis (area 45) in the ventrolateral frontal lobe. As in the macaque monkey, area 44 has distinct connections with the rostral inferior parietal lobule via the third branch of the superior longitudinal fasciculus. In contrast, area 45 connects with the superior temporal gyrus, anterior to Heschl's gyrus, via the extreme capsule fiber system. These results highlight the differences in connectivity between areas 44 and 45 which had previously been thought to be uniformly connected with the posterior temporal region via the arcuate fasciculus. We also provide evidence in the human brain that the arcuate fasciculus, as in the macaque monkey brain, connects the posterior superior temporal region with dorsolateral frontal areas 8 and rostral 6 that lie above areas 44 and 45. Thus, monkey and human evidence suggests that the connections of areas 44 and 45 are much more differentiated than had previously been thought and provide the basis for studies searching for their differential contribution in function.

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Section: Methodsmentioning

confidence: 99%

Section: Limitations Of Diffusion-weighted Datamentioning

confidence: 99%

Dissociating the Human Language Pathways with High Angular Resolution Diffusion Fiber Tractography

Frey¹,

Campbell²,

Pike³

et al. 2008

J. Neurosci.

391

364

View full text Add to dashboard Cite

show abstract

“…We compare our segmentation algorithm with conventional streamline fibre tractography with a user-defined, extensive start region of interest (ROI). To do so, a streamline tractography approach robust to complex sub-voxel geometries [12] was used. The ROI was hand drawn on the entire length of the corpus callosum (CC) in the mid sagittal region of the brain.…”

Section: Methodsmentioning

confidence: 99%

Streamline Flows for White Matter Fibre Pathway Segmentation in Diffusion MRI

Savadjiev

Campbell

Pike

et al. 2008

Medical Image Computing and Computer-Assisted Intervention – MICCAI 2008

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Abstract. We introduce a fibre tract segmentation algorithm based on the geometric coherence of fibre orientations as indicated by a streamline flow model. The inference of local flow approximations motivates a pairwise consistency measure between fibre ODF maxima. We use this measure in a recursive algorithm to cluster consistent ODF maxima, leading to the segmentation of white matter pathways. The method requires minimal seeding compared to streamline tractography-based methods, and allows multiple tracts to pass through the same voxels. We illustrate the approach with a segmentation of the corpus callosum and one of the cortico-spinal tract, with each example seeded at a single voxel.

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“…proposed in [5] to compute the anisotropy of each fibre population within the same voxel. Other relevant methods include the labelling of crossing and fanning fibre populations [6] and the computation of a torsion index [7], both using inter-voxel computations. To the extent of our knowledge, the present paper describes the first statistical method for assessing the partitioning of fibre populations within the same voxel.…”

Section: Introductionmentioning

confidence: 99%

Apparent Intravoxel Fibre Population Dispersion (FPD) Using Spherical Harmonics

Assemlal

Campbell

Pike

et al. 2011

Lecture Notes in Computer Science

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Abstract. The vast majority of High Angular Resolution Diffusion Imaging (HARDI) modeling methods recover networks of neuronal fibres, using a heuristic extraction of their local orientation. In this paper, we present a method for computing the apparent intravoxel Fibre Population Dispersion (FPD), which conveys the manner in which distinct fibre populations are partitioned within the same voxel. We provide a statistical analysis, without any prior assumptions on the number or size of these fibre populations, using an analytical formulation of the diffusion signal autocorrelation function in the spherical harmonics basis. We also propose to extract features of the FPD obtained in the group of rotations, using several metrics based on unit quaternions. We show results on simulated data and on physical phantoms, that demonstrate the effectiveness of the FPD to reveal regions with crossing tracts, in contrast to the standard anisotropy measures.

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Labeling of ambiguous subvoxel fibre bundle configurations in high angular resolution diffusion MRI

Cited by 65 publications

References 28 publications

Dissociating the Human Language Pathways with High Angular Resolution Diffusion Fiber Tractography

Dissociating the Human Language Pathways with High Angular Resolution Diffusion Fiber Tractography

Streamline Flows for White Matter Fibre Pathway Segmentation in Diffusion MRI

Apparent Intravoxel Fibre Population Dispersion (FPD) Using Spherical Harmonics

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