2022
DOI: 10.1101/2022.08.23.504719
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Label-free virus-antibody interaction monitoring in real time by common-path interferometry

Abstract: Viruses can affect all life forms, raising concerns about virus detection and quantification of small nanoparticles. This paper uses a label-free, full-field, incoherently illuminated common-path interferometric method to detect, track, and quantify biotic nanoparticles. The detection consists of amplifying the light scattered by single nanoparticles in the sample solution. Then, the use of single-particle tracking analysis is used to monitor the change in particle diffusive mobility. With this approach, the r… Show more

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