Label-free serum proteomics for the identification of the putative biomarkers of postoperative pain in patients with gastric cancer

Li, Jianing; Li, Shuo; zhang, Tianzhuo; Yu, Ling; Wei, Jin; Wu, Mengge; Xie, Yining; Tan, Huan

doi:10.1039/d2mo00296e

Cited by 2 publications

(3 citation statements)

References 37 publications

(49 reference statements)

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“…They identified a number of distinct proteins that were connected to postoperative acute pain and were active in inflammatory pathways, blood coagulation cascades, and extracellular matrix (ECM)-related activities. They also noted that F13B could be a novel marker for acute postoperative pain [ 111 ]. Similar to the previous section, these data from the most important studies are summarized ( Table 4 ).…”

Section: Discussionmentioning

confidence: 99%

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Personalized Medicine in Cancer Pain Management

Raad

López

Sharafshah

et al. 2023

JPM

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Background: Previous studies have documented pain as an important concern for quality of life (QoL) and one of the most challenging manifestations for cancer patients. Thus, cancer pain management (CPM) plays a key role in treating pain related to cancer. The aim of this systematic review was to investigate CPM, with an emphasis on personalized medicine, and introduce new pharmacogenomics-based procedures for detecting and treating cancer pain patients. Methods: This study systematically reviewed PubMed from 1990 to 2023 using keywords such as cancer, pain, and personalized medicine. A total of 597 publications were found, and after multiple filtering processes, 75 papers were included. In silico analyses were performed using the GeneCards, STRING-MODEL, miRTargetLink2, and PharmGKB databases. Results: The results reveal that recent reports have mainly focused on personalized medicine strategies for CPM, and pharmacogenomics-based data are rapidly being introduced. The literature review of the 75 highly relevant publications, combined with the bioinformatics results, identified a list of 57 evidence-based genes as the primary gene list for further personalized medicine approaches. The most frequently mentioned genes were CYP2D6, COMT, and OPRM1. Moreover, among the 127 variants identified through both the literature review and data mining in the PharmGKB database, 21 variants remain as potential candidates for whole-exome sequencing (WES) analysis. Interestingly, hsa-miR-34a-5p and hsa-miR-146a-5p were suggested as putative circulating biomarkers for cancer pain prognosis and diagnosis. Conclusions: In conclusion, this study highlights personalized medicine as the most promising strategy in CPM, utilizing pharmacogenomics-based approaches to alleviate cancer pain.

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Section: Discussionmentioning

confidence: 99%

“…Similar to the previous section, these data from the most important studies are summarized (Table 4). F13B Sufentanil [111] Ref. refers to the references in the main text.…”

Section: Personalized Medicine In Cancer-pain Managementmentioning

confidence: 99%

Personalized Medicine in Cancer Pain Management

Raad

López

Sharafshah

et al. 2023

JPM

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“… 755 F13B Serum Postoperative pain 80 0.859 - - Preoperative serum F13B predicts the required postoperative dosages of sufentanil for gastric cancer patients. 756 Gal-9 Serum Endometriosis 135 0.973 0.940 0.938 Gal-9 effectively differentiates endometriosis patients from healthy controls. 757 GTF2H2, KLHL5, LRRC37A4P, PRR24, MRPL23 Skin Neuropathic pain 227 0.830 - - This gene signature can differentiate neuropathic pain patients from healthy controls.…”

Section: Approaches For Pain Assessment and Diagnosismentioning

confidence: 99%

Pathology of pain and its implications for therapeutic interventions

Cao,

Xu,

Shi

et al. 2024

Sig Transduct Target Ther

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Pain is estimated to affect more than 20% of the global population, imposing incalculable health and economic burdens. Effective pain management is crucial for individuals suffering from pain. However, the current methods for pain assessment and treatment fall short of clinical needs. Benefiting from advances in neuroscience and biotechnology, the neuronal circuits and molecular mechanisms critically involved in pain modulation have been elucidated. These research achievements have incited progress in identifying new diagnostic and therapeutic targets. In this review, we first introduce fundamental knowledge about pain, setting the stage for the subsequent contents. The review next delves into the molecular mechanisms underlying pain disorders, including gene mutation, epigenetic modification, posttranslational modification, inflammasome, signaling pathways and microbiota. To better present a comprehensive view of pain research, two prominent issues, sexual dimorphism and pain comorbidities, are discussed in detail based on current findings. The status quo of pain evaluation and manipulation is summarized. A series of improved and innovative pain management strategies, such as gene therapy, monoclonal antibody, brain-computer interface and microbial intervention, are making strides towards clinical application. We highlight existing limitations and future directions for enhancing the quality of preclinical and clinical research. Efforts to decipher the complexities of pain pathology will be instrumental in translating scientific discoveries into clinical practice, thereby improving pain management from bench to bedside.

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Label-free serum proteomics for the identification of the putative biomarkers of postoperative pain in patients with gastric cancer

Abstract: Background: Individualized pain therapy conforms to the concept of precision medicine and contribute to adequate pain management after surgery. Preoperative biomarkers associated with postoperative pain may instruct anesthesiologists to improve...

Cited by 2 publications

References 37 publications

Personalized Medicine in Cancer Pain Management

Personalized Medicine in Cancer Pain Management

Pathology of pain and its implications for therapeutic interventions

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