Label-free sensing of virus-like particles below the sub-diffraction limit by wide-field photon state parametric imaging of a gold nanodot array

Xiao, Jin; Zhang, Heng; Ni, Bin; Liu, Weiping; Hou, Lianping; Marsh, J.H.; Ye, Shengwei; Sun, Xiao; Li, Xiaofeng; Li, Shanhu; Dong, Lei; Hou, Jamie Jiangmin; Sun, Mengtao; Xu, Bin; Xiong, Jichuan; Li, Xuefeng

doi:10.1039/d1na00603g

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…A polarization parameter imaging technique (PIMI, Polarized Indirect Microscopic Imaging) is utilized to detect the change of polarization state with a subwavelength resolution [14,15]. The detecting process of PIMI system is shown in Fig 2.…”

Section: Simulation Setup and Pimi Calculationmentioning

confidence: 99%

Scattering field enhanced biosensing based on sub-wavelength split-ring plasmonic cavity with high Q-factor

Jin

Xiong

et al. 2023

Plasmonics in Biology and Medicine XX

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Plasmonic structures are widely used in modern biosensor design. various plasmonic resonant cavities could efficiently achieve a high Q-factor, improving the local field intensity to enhance photoluminescence or SERS (Surface-Enhanced Raman Scattering) of small molecules. Also, the combination between virus-like particles and plasmonic structures could significantly influence the scattering spectrum and field, which is utilized as a method for biological particle detection. In this paper, we designed one kind of gold plasmonic cavity with the shape of a split-ring. An edge gap and a bonus center bulge are introduced in the split-ring structure. Our simulation is based on Finite Difference Time Domain (FDTD) method. Polarization Indirect Microscopic Imaging (PIMI) technique is used here to detect far-field mode distribution under the resonant wavelength. The simulation results demonstrate resonant peaks in the visible spectrum at about 600 nm with a Q-factor reaches to 74. Localized hot spots are generated by an edge dipole mode and a cavity hexapole mode at resonant wavelength, which is according to dark points in the PIMI sinδ image. Also, the split-ring cavity shows a sensitivity when combined with biological particles. The scattering distribution is evidently changed as a result of energy exchange between particles and split-ring cavity, indicating a promising possibility for biosensing.

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Section: Simulation Setup and Pimi Calculationmentioning

confidence: 99%

Scattering field enhanced biosensing based on sub-wavelength split-ring plasmonic cavity with high Q-factor

Jin

Xiong

et al. 2023

Plasmonics in Biology and Medicine XX

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“…Recently, we proposed a virus-like particle detection method based on gold nanodots array on the Si substrate [ 33 ]. The spatial symmetry of the structure and dielectric environment of the nanodots will be broken when a virus-like particle appears in its vicinity, and the corresponding polarization parameters of the scattered light in the far field would therefore generate asymmetric patterns, which are utilized for quantitative analysis.…”

Section: Introductionmentioning

confidence: 99%

Asymmetric parameter enhancement in the split-ring cavity array for virus-like particle sensing

Jin¹,

Li²,

Ye³

et al. 2023

Biomed. Opt. Express

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Quantitative detection of virus-like particles under a low concentration is of vital importance for early infection diagnosis and water pollution analysis. In this paper, a novel virus detection method is proposed using indirect polarization parametric imaging method combined with a plasmonic split-ring nanocavity array coated with an Au film and a quantitative algorithm is implemented based on the extended Laplace operator. The attachment of viruses to the split-ring cavity breaks the structural symmetry, and such asymmetry can be enhanced by depositing a thin gold film on the sample, which allows an asymmetrical plasmon mode with a large shift of resonance peak generated under transverse polarization. Correspondingly, the far-field scattering state distribution encoded by the attached virus exhibits a specific asymmetric pattern that is highly correlated to the structural feature of the virus. By utilizing the parametric image sinδ to collect information on the spatial photon state distribution and far-field asymmetry with a sub-wavelength resolution, the appearance of viruses can be detected. To further reduce the background noise and enhance the asymmetric signals, an extended Laplace operator method which divides the detection area into topological units and then calculates the asymmetric parameter is applied, enabling easier determination of virus appearance. Experimental results show that the developed method can provide a detection limit as low as 56 vp/150µL on a large scale, which has great potential in early virus screening and other applications.

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Sub-wavelength visualization of near-field scattering mode of plasmonic nano-cavity in the far-field

Xiao

Cheng

et al. 2023

Nanophotonics

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Spatial visualization of mode distribution of light scattering from plasmonic nanostructures is of vital importance for understanding the scattering mechanism and applications based on these plasmonic nanostructures. A long unanswered question in how the spatial information of scattered light from a single plasmonic nanostructure can be recovered in the far-field, under the constraints of the diffraction limit of the detection or imaging optical system. In this paper, we reported a theoretical model on retrieving local spatial information of scattered light by plasmonic nanostructures in a far-field optical imaging system. In the far-field parametric sin δ images, singularity points corresponding to near-field hot spots of the edge mode and the gap mode were resolved for gold ring and split rings with subwavelength diameters and feature sizes. The experimental results were verified with Finite Difference Time Domain (FDTD) simulation in the near-field and far-field, for the edge mode and the gap mode at 566 nm and 534 nm, respectively. In sin δ image of split-ring, two singularity points associated with near-field hot spots were visualized and resolved with the characteristic size of 90 and 100 nm, which is far below the diffraction limit. The reported results indicate the feasibility of characterizing the spatial distribution of scattering light in the far-field and with sub-wavelength resolution for single plasmonic nanostructures with sub-wavelength feature sizes.

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Label-free sensing of virus-like particles below the sub-diffraction limit by wide-field photon state parametric imaging of a gold nanodot array

Abstract: A parallel four-quadrant sensing method utilizing a specially designed gold nanodot array is created for sensing virus-like particles with sub-diffraction limit size (~100 nm) in a wide-field image. Direct label-free...

Cited by 4 publications

References 29 publications

Scattering field enhanced biosensing based on sub-wavelength split-ring plasmonic cavity with high Q-factor

Scattering field enhanced biosensing based on sub-wavelength split-ring plasmonic cavity with high Q-factor

Asymmetric parameter enhancement in the split-ring cavity array for virus-like particle sensing

Sub-wavelength visualization of near-field scattering mode of plasmonic nano-cavity in the far-field

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