Label-free liquid crystal biosensor for cecropin B detection

Zhang, Jiao; Su, Xiuxia; Yang, Dong; Luan, Chonglin

doi:10.1016/j.talanta.2018.04.004

Cited by 27 publications

(15 citation statements)

References 30 publications

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“…All these advantages lend LC-based biosensors great potential for the next generation of high-sensitivity, low-cost and label-free bioassays. Up to now, various investigations of LC-based biosensors have been reported [427][428][429][430][431][432]. Very recently, Lee et al reported a label-free protein (bovine serum albumin, BSA) quantitative detection by a dual-frequency LC (DFLC)-based biosensor [433].…”

Section: Biosensorsmentioning

confidence: 99%

Perspectives in Liquid-Crystal-Aided Nanotechnology and Nanoscience

2019

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The research field of liquid crystals and their applications is recently changing from being largely focused on display applications and optical shutter elements in various fields, to quite novel and diverse applications in the area of nanotechnology and nanoscience. Functional nanoparticles have recently been used to a significant extent to modify the physical properties of liquid crystals by the addition of ferroelectric and magnetic particles of different shapes, such as arbitrary and spherical, rods, wires and discs. Also, particles influencing optical properties are increasingly popular, such as quantum dots, plasmonic, semiconductors and metamaterials. The self-organization of liquid crystals is exploited to order templates and orient nanoparticles. Similarly, nanoparticles such as rods, nanotubes and graphene oxide are shown to form lyotropic liquid crystal phases in the presence of isotropic host solvents. These effects lead to a wealth of novel applications, many of which will be reviewed in this publication. the observation of chirality from achiral molecules, resulting from sterically induced packing of the bent-core mesogens [10], such as ferroelectricity or the formation of helical superstructures in the B7 phase [14]. Thermotropic LCs are commonly constituted by single organic entities or mixtures thereof, which exhibit various mesophases at different temperatures or pressures [15], illustrated in Figure 1b. As the temperature rises, a typical thermotropic LC passes through higher ordered phases, also called soft crystals, the hexatic smectic phases with positional order as well as bond orientational order, through the fluid smectic phases (SmC and SmA), which exhibit both positional and orientational order, and finally to the nematic phase (N) with purely orientational order, into the isotropic phase. The number of different phases observed depends on the chemical composition, symmetry and order of the LC molecules. About 25 different thermotropic phases are known to date, and they are still increasing in number. Appl. Sci. 2019, 9, x FOR PEER REVIEW 2 of 47 unique effects of the observation of chirality from achiral molecules, resulting from sterically induced packing of the bent-core mesogens [10], such as ferroelectricity or the formation of helical superstructures in the B7 phase [14]. Thermotropic LCs are commonly constituted by single organic entities or mixtures thereof, which exhibit various mesophases at different temperatures or pressures [15], illustrated in Figure 1b. As the temperature rises, a typical thermotropic LC passes through higher ordered phases, also called soft crystals, the hexatic smectic phases with positional order as well as bond orientational order, through the fluid smectic phases (SmC and SmA), which exhibit both positional and orientational order, and finally to the nematic phase (N) with purely orientational order, into the isotropic phase. The number of different phases observed depends on the chemical composition, symmetry and order of the LC molecules. About...

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Section: Biosensorsmentioning

confidence: 99%

Perspectives in Liquid-Crystal-Aided Nanotechnology and Nanoscience

2019

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“…The solid substrates are usually glass slides, which are chemically treated with alignment reagents, such as N, N-dimethyl-N-octadecyl-3-aminopropyl trimethoxysilyl chloride (DMOAP) and octyltrichlorosilane (OTS), to predefine a homeotropic alignment of LCs (Figure 1a). In order to detect the target molecules, a specific concentration of recognition element, such as proteins [36,58,59] and nucleic acids [19,60,61], is introduced on the alignment reagent layer of the substrates without disrupting the homeotropic alignment of LCs (Figure 1b), indicating a dark appearance under a polarized optical microscope. The target molecules specifically interacting with the recognition element on the substrate would trigger a tilted alignment of LCs (Figure 1c), exhibiting a bright appearance under the polarized optical microscope and thus can be detected with the naked eye.…”

Section: Microfluidics In Lc Planar Sensing Platformsmentioning

confidence: 99%

Applications of Microfluidics in Liquid Crystal-Based Biosensors

2021

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Liquid crystals (LCs) with stimuli-responsive configuration transition and optical anisotropic properties have attracted enormous interest in the development of simple and label-free biosensors. The combination of microfluidics and the LCs offers great advantages over traditional LC-based biosensors including small sample consumption, fast analysis and low cost. Moreover, microfluidic techniques provide a promising tool to fabricate uniform and reproducible LC-based sensing platforms. In this review, we emphasize the recent development of microfluidics in the fabrication and integration of LC-based biosensors, including LC planar sensing platforms and LC droplets. Fabrication and integration of LC-based planar platforms with microfluidics for biosensing applications are first introduced. The generation and entrapment of monodisperse LC droplets with different microfluidic structures, as well as their applications in the detection of chemical and biological species, are then summarized. Finally, the challenges and future perspectives of the development of LC-based microfluidic biosensors are proposed. This review will promote the understanding of microfluidic techniques in LC-based biosensors and facilitate the development of LC-based microfluidic biosensing devices with high performance.

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“…LCs have a long history of being used as responsive materials in different technologies, thanks to their unique properties. Numerous studies have demonstrated the possibility to produce rapid diagnostic optical sensors for temperature ( Gao et al, 2014 ), pH (long Chen et al, 2018 ), humidity ( Saha et al, 2012 ; Zhao et al, 2019 ), gas ( Esteves et al, 2020 ) and molecules (ang Niu et al, 2017 ; Zhang et al, 2018 ) based on LCs. The most widespread sensors are those for temperature, owing to the diversity and availability of thermotropic LCs.…”

Section: Introductionmentioning

confidence: 99%

Thermotropic Liquid Crystals for Temperature Mapping

Mišković

Malafronte

Minetti

et al. 2022

Front. Bioeng. Biotechnol.

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Wound management in Space is an important factor to be considered in future Human Space Exploration. It demands the development of reliable wound monitoring systems that will facilitate the assessment and proper care of wounds in isolated environments, such as Space. One possible system could be developed using liquid crystal films, which have been a promising solution for real-time in-situ temperature monitoring in healthcare, but they are not yet implemented in clinical practice. To progress in the latter, the goal of this study is twofold. First, it provides a full characterization of a sensing element composed of thermotropic liquid crystals arrays embedded between two elastomer layers, and second, it discusses how such a system compares against non-local infrared measurements. The sensing element evaluated here has an operating temperature range of 34–38°C, and a quick response time of approximately 0.25 s. The temperature distribution of surfaces obtained using this system was compared to the one obtained using the infrared thermography, a technique commonly used to measure temperature distributions at the wound site. This comparison was done on a mimicked wound, and results indicate that the proposed sensing element can reproduce the temperature distributions, similar to the ones obtained using infrared imaging. Although there is a long way to go before implementing the liquid crystal sensing element into clinical practice, the results of this work demonstrate that such sensors can be suitable for future wound monitoring systems.

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Label-free liquid crystal biosensor for cecropin B detection

Cited by 27 publications

References 30 publications

Perspectives in Liquid-Crystal-Aided Nanotechnology and Nanoscience

Perspectives in Liquid-Crystal-Aided Nanotechnology and Nanoscience

Applications of Microfluidics in Liquid Crystal-Based Biosensors

Thermotropic Liquid Crystals for Temperature Mapping

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