Label-free immunosensor for prostate-specific antigen based on single-walled carbon nanotube array-modified microelectrodes

Okuno, Junko; Maehashi, Kenzo; Kerman, Kağan; Takamura, Yuzuru; Matsumoto, Kazuhiko; Tamiya, Eiichi

doi:10.1016/j.bios.2006.09.038

Cited by 292 publications

(155 citation statements)

References 22 publications

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“…Okuno et al fabricated microelectrode arrays modified with SWCNTs for label-free immunosensing of total prostate-specific antigen (T-PSA) using differential pulse voltammetry (DPV) [51]. Fig.…”

Section: Cnt-based Immunosensorsmentioning

confidence: 99%

“…The performance of the label-free electrochemical immunosensor seems promising for further clinical applications [51]. Viswanathan et al developed a CNT-based immunosensor for sensitive detection of cholera toxin (CT), in which monoclonal antibody against the B subunit of CT is linked to poly(3,4-ethylenedioxythiophene) coated on a Nafion-supported MWCNT caste film on a glassy-carbon electrode, and potassium ferrocyanide-encapsulated and ganglioside (GM1)-functionalized liposomes act as highly specific recognition labels for the amplified detection of CT [43].…”

Section: Cnt-based Immunosensorsmentioning

confidence: 99%

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Functionalized carbon nanotubes and nanofibers for biosensing applications

Wang

Lin

2008

TrAC Trends in Analytical Chemistry

264

131

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This review summarizes recent advances in electrochemical biosensors based on carbon nanotubes (CNTs) and carbon nanofibers (CNFs) with an emphasis on applications of CNTs. CNTs and CNFs have unique electric, electrocatalytic and mechanical properties, which make them efficient materials for developing electrochemical biosensors.We discuss functionalizing CNTs for biosensors. We review electrochemical biosensors based on CNTs and their various applications (e.g., measurement of small biological molecules and environmental pollutants, detection of DNA, and immunosensing of disease biomarkers). Moreover, we outline the development of electrochemical biosensors based on CNFs and their applications. Finally, we discuss some future applications of CNTs.

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Section: Cnt-based Immunosensorsmentioning

confidence: 99%

Section: Cnt-based Immunosensorsmentioning

confidence: 99%

Functionalized carbon nanotubes and nanofibers for biosensing applications

Wang

Lin

2008

TrAC Trends in Analytical Chemistry

264

131

View full text Add to dashboard Cite

show abstract

“…Figure 3(b) shows the electrochemical signals of CNTmodifi ed electrodes recorded using differential pulse voltammetry (DPV). (26) The peak current signal was obtained at +0.5 V from only PSA-mAb, as indicated by the dotted line in Fig. 3(b).…”

Section: (A) Figure 2(b)mentioning

confidence: 94%

Electrochemical Amperometric Biosensors Based on Directly Synthesized Carbon Nanotube Electrodes

2009

Sensors and Materials

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In recent years, label-free detections of biomolecules have attracted great attention in many fi elds of life science such as genomics, clinical diagnosis, and practical pharmacy. In this article, we review electrochemical amperometric biosensors based on carbon nanotube (CNT) electrodes. In electrochemical detections, CNT electrodes promote electron transfer reactions on CNT surfaces. Since CNTs have a large specifi c surface area, the direct synthesization of CNTs on electrodes in amperometric biosensors is expected to signifi cantly enhance electroactive surface area. In this review, we discuss the technology and performance of the electrochemical biosensors based on CNT electrodes and describe microfl udic chips with multibiosensors based on CNT electrodes for commercialization.

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“…(3) Therefore, CNTs are promising materials for advanced nanoelectronic devices, quantum-effect-based devices and microelectrodes. (4)(5)(6)(7)(8)(9)(10)(11) In particular, CNT fi eld-effect transistors (CNTFETs) with single-wall carbon nanotube (SWNT) conducting channels are promising candidates for highly sensitive and labelfree biosensors and chemical sensors owing to their unique geometries with high surfaceto-volume ratio and high aspect ratio. In the case of SWNTs, every atom is on the surface and is exposed to the environment.…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive Biosensors Based on High-Performance Carbon Nanotube Field-Effect Transistors

2009

Sensors and Materials

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Electronic detection of biomolecules has been attracting much interest in the fi elds of clinical diagnosis, pharmacy and biotechnology. In particular, developing highly sensitive, label-free, cost-effective, simple and disposable sensors is strongly required for home medical care. Carbon nanotube fi eld-effect transistors (CNTFETs) with singlewall carbon nanotube (SWNT) conducting channels are a promising candidate for highly sensitive biosensors owing to the excellent electronic and mechanical properties of SWNTs. Therefore, chemical sensors and biosensors based on CNTFETs have been extensively studied and investigated in academia and industry over the years. In this review, we will cover recent advances in the detection of biological species in various manners using CNTFETs. This article highlights the high-performance characteristics of CNTFETs, the detection of deoxyribonucleic acid (DNA) hybridization and proteins using CNTFET sensors and an effective measurement system for the highly sensitive detection of analytes, mainly focusing on works that were carried out in our laboratory.

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Label-free immunosensor for prostate-specific antigen based on single-walled carbon nanotube array-modified microelectrodes

Cited by 292 publications

References 22 publications

Functionalized carbon nanotubes and nanofibers for biosensing applications

Functionalized carbon nanotubes and nanofibers for biosensing applications

Electrochemical Amperometric Biosensors Based on Directly Synthesized Carbon Nanotube Electrodes

Highly Sensitive Biosensors Based on High-Performance Carbon Nanotube Field-Effect Transistors

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