Label-free immunodetection with CMOS-compatible semiconducting nanowires

Stern, Eric; Klemic, James F.; Routenberg, David A.; Wyrembak, Pauline N.; Turner-Evans, Daniel B.; Hamilton, Andrew D.; LaVan, David A.; Fahmy, Tarek M.; Reed, Mark A.

doi:10.1038/nature05498

Cited by 1,268 publications

(1,133 citation statements)

References 28 publications

Supporting

Mentioning

1,103

Contrasting

Unclassified

Order By: Relevance

“…concentration [1][2][3][4][5] instead of the linear dependence predicted from classical theory and observed in fluorescence measurements [9] (see the list of four puzzles in section I). Numerical solution of Eqs.…”

Section: To Our Knowledge This Is the First Theoretical Explanation Tmentioning

confidence: 97%

“…Functionalized Silicon Nanowire (Si-NW) devices have been used to demonstrate detection of DNA [1][2][3] and proteins [4][5] at very low concentrations (Fig. 1a).…”

Section: Introductionmentioning

confidence: 99%

“…2a, [1][2][3][4][5]), (ii) linear dependence on pH which is crucial for protein detection (Fig. 2b, [5,6]), (iii) non-linear dependence of sensitivity on electrolyte concentration (Fig.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Screening-Limited Response of NanoBiosensors

2008

View full text Add to dashboard Cite

ABSTRACT:Despite tremendous potential of highly sensitive electronic detection of bio-molecules by nanoscale biosensors for genomics and proteomic applications, many aspects of experimentally observed sensor response (S) are unexplained within consistent theoretical frameworks of kinetic response or electrical screening. In this paper, we combine analytic solutions of Poisson-Boltzmann and reaction-diffusion equations to show that the electrostatic screening within an ionic environment limits the response of nanobiosensor such that ( ) ( ) ( ) ( ) [ ]

show abstract

Section: To Our Knowledge This Is the First Theoretical Explanation Tmentioning

confidence: 97%

“…Functionalized Silicon Nanowire (Si-NW) devices have been used to demonstrate detection of DNA [1][2][3] and proteins [4][5] at very low concentrations (Fig. 1a).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Screening-Limited Response of NanoBiosensors

2008

View full text Add to dashboard Cite

show abstract

“…S ilicon nanowires (SiNWs) have attracted much attention for many applications, such as field effect transistors, [1][2][3] nanosensors, [4][5][6] and solar cells. [7][8][9] These applications take advantage of the high crystallinity and/or large surface area of SiNWs.…”

mentioning

confidence: 99%

Lithium Insertion In Silicon Nanowires: An ab Initio Study

et al. 2010

View full text Add to dashboard Cite

The ultrahigh specific lithium ion storage capacity of Si nanowires (SiNWs) has been demonstrated recently and has opened up exciting opportunities for energy storage. However, a systematic theoretical study on lithium insertion in SiNWs remains a challenge, and as a result, understanding of the fundamental interaction and microscopic dynamics during lithium insertion is still lacking. This paper focuses on the study of single Li atom insertion into SiNWs with different sizes and axis orientations by using full ab initio calculations. We show that the binding energy of interstitial Li increases as the SiNW diameter grows. The results show that the Li surface diffusion has a much higher chance to occur than the surface to core diffusion, which is consistent with the experimental observation that the Li insertion in SiNWs is layer by layer from surface to inner region. After overcoming a large barrier crossing surface-to-intermediate region, the diffusion toward center has a higher possibility to occur than the inverse process.KEYWORDS Silicon nanowire, anode, lithium ion battery, ab initio simulation, binding energy, diffusion barrier S ilicon nanowires (SiNWs) have attracted much attention for many applications, such as field effect transistors, 1-3 nanosensors, 4-6 and solar cells. 7-9 These applications take advantage of the high crystallinity and/or large surface area of SiNWs. Excitingly, SiNWs have recently been demonstrated as ultrahigh capacity lithium ion battery negative electrodes, 10 which opens up exciting opportunities for energy storage devices. Silicon has the highest known specific charge capacity (4200 mAh/g), which is ∼10 times larger than that of the graphite carbon used in existing technology. 11 However, the 300% volume expansion upon lithium insertion has caused pulverization or mechanical fracture in micrometer particle and bulk Si. The success of using SiNWs lies in their facile strain relaxation without mechanical breaking, efficient electron transport along their long axis, and large lithium ion flux due to their large surface area. Since the important demonstration of SiNWs as lithium ion battery anodes, a variety of Si nanostructure morphologies has been demonstrated to overcome the mechanical breaking issues and perform well as anodes. Si nanostructures shown to exhibit good performance include crystallineamorphous core-shell Si NWs, 12 carbon-amorphous Si core-shell NWs, 13 Si nanotubes, 14 porous Si particles, 15 and an ordered macroporous carbon-Si composite. 16 However, experimental investigation has mainly been focused on electrochemical cycling of Si-Li compounds and phase transitions during Li insertion; all the Si-Li phases were found when the system is rich in Li atoms. 10,17 Although the Si-Li compound can be accurately analyzed, the fundamental interaction between Li and Si atoms and the microscopic dynamic process during Li insertion still remain unknown.On the theoretical side, there have been studies on electronic properties, 18-20 surface effects, 21,22 B or P...

show abstract

“…In the past, much attention has been paid to 1D semiconducting nanostructures, for example nanorods, nanowires (NWs), nanobelts and nanotubes, because their unique properties enable promising applications as functional components in nanoscale electronics and optoelectronics 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41. Due to the large surface to volume ratio, 1D nanostructures have a large number of surface trap states which can prolong the photocarrier lifetimes.…”

Section: Introductionmentioning

confidence: 99%

Flexible Photodetectors Based on 1D Inorganic Nanostructures

2015

View full text Add to dashboard Cite

Flexible photodetectors with excellent flexibility, high mechanical stability and good detectivity, have attracted great research interest in recent years. 1D inorganic nanostructures provide a number of opportunities and capabilities for use in flexible photodetectors as they have unique geometry, good transparency, outstanding mechanical flexibility, and excellent electronic/optoelectronic properties. This article offers a comprehensive review of several types of flexible photodetectors based on 1D nanostructures from the past ten years, including flexible ultraviolet, visible, and infrared photodetectors. High‐performance organic‐inorganic hybrid photodetectors, as well as devices with 1D nanowire (NW) arrays, are also reviewed. Finally, new concepts of flexible photodetectors including piezophototronic, stretchable and self‐powered photodetectors are examined to showcase the future research in this exciting field.

show abstract

Label-free immunodetection with CMOS-compatible semiconducting nanowires

Cited by 1,268 publications

References 28 publications

Screening-Limited Response of NanoBiosensors

Screening-Limited Response of NanoBiosensors

Lithium Insertion In Silicon Nanowires: An ab Initio Study

Flexible Photodetectors Based on 1D Inorganic Nanostructures

Contact Info

Product

Resources

About